DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PDZ-GEF and Gm3409

DIOPT Version :9

Sequence 1:	NP_609012.2	Gene:	PDZ-GEF / 33881	FlyBaseID:	FBgn0265778	Length:	1573	Species:	Drosophila melanogaster
Sequence 2:	XP_006504843.1	Gene:	Gm3409 / 100041566	MGIID:	3781587	Length:	319	Species:	Mus musculus

Alignment Length:	318	Identity:	59/318 - (18%)
Similarity:	107/318 - (33%)	Gaps:	100/318 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 KRGHVVIR---------GTPERLLQQLVEENSMTDPTYVEDFLLTHRIFIQNPQEVTSKLLHWFD 333
            ||.|:.|.         .:...:|..|:...:...|..::|        .|..:.:...|..||.
Mouse    83 KRDHICITIFLGVYRTYASTWEVLDLLMRTYASFRPDCIKD--------QQTKRAIFRFLFGWFK 139

  Fly   334 LEQVDAHKTQELRDRVTRVVLLWVNNHF--TDFEADYEMMEFLEVFEALLERKKLLSQLRL-LHI 395
            ....|.:::.:|  .|.|..:.:|.::.  :|.:...|::..||..||:        :|:: ...
Mouse   140 KYPQDFYESPDL--AVVRQFIDYVKHNVPSSDVDRARELLSLLEDQEAI--------ELQIEQDF 194

  Fly   396 ACAAKARMRSCTLTRSSRDEPLNFRIVGGYELRGVAIATGNAAVGIYISHVEPGSKAQDVGLKRG 460
            |.|.:...:..    |.|.|.|..|                           |.|:.:..|.|:.
Mouse   195 ATAPEPSEQDA----SGRQETLALR---------------------------PASETEPQGDKQP 228

  Fly   461 DQIHE-VNGQSLDHVTSKRALEILTGTTHLSISVKSNLLGFKEIMQALEHGGGTAGSGSISAGSG 524
            .:..| |.|..||....|..:| |..:.|                ||:....||.....::|..
Mouse   229 REDPELVKGAVLDPSEPKATIE-LPPSLH----------------QAVPTSDGTLSPVDVTADE- 275

  Fly   525 SFKSVRSPRRICANDIAKLHGRSDSTTDELSSVSASNR---AHMVRLSSVDMLLDQPD 579
                        |..:|     :|...|..:.||.:.:   ::.|:|.:.|.::..|:
Mouse   276 ------------ATGVA-----ADEAADVAADVSPARQLFVSYTVQLGTPDFVIPLPE 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571	25/132 (19%)
		PDZ_signaling	404..494	CDD:238492	18/90 (20%)
		DegQ	<422..494	CDD:223343	13/72 (18%)
		PDZ_GEF_RA	757..841	CDD:176380
		RasGEF	871..1050	CDD:279011
		Rhomboid_SP	1252..>1357	CDD:289371
Gm3409	XP_006504843.1	REM	89..186	CDD:100121	19/106 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900