DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PDZ-GEF and Gm3404

DIOPT Version :9

Sequence 1:	NP_609012.2	Gene:	PDZ-GEF / 33881	FlyBaseID:	FBgn0265778	Length:	1573	Species:	Drosophila melanogaster
Sequence 2:	XP_011239299.1	Gene:	Gm3404 / 100041554	MGIID:	3781582	Length:	311	Species:	Mus musculus

Alignment Length:	170	Identity:	38/170 - (22%)
Similarity:	59/170 - (34%)	Gaps:	45/170 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1210 QLSIYSHTSSSSAPNSSLSLRKRHPSSPTLSTTSSTSSTSDHQRRQMHNNGPKFGTASPQAVKKM 1274
            :|.|....:::..|:...:..::...:|  ...|.|....|.|.|:           .|:.||..
Mouse   187 ELQIEQDFATAPEPSEQDASGRQETLAP--RPASETEPQGDKQPRE-----------DPELVKGA 238

  Fly  1275 LSLSESSKIRPHQPFVPRHGSTMAGVIPPLHHMHAAHGFSTPSPGGVVTSPATSAVANVQCTPSP 1339
            :.          .||.|:  :|:.  :||..|........|.||..|....||...|:|    ||
Mouse   239 VL----------DPFEPK--ATIE--LPPSLHQAVPTSDGTLSPVDVTADEATGVAADV----SP 285

  Fly  1340 SPCSHRRLASGGNIIPSRAIHERSHSDTPAPPPPLPSVDL 1379
            :    |:|.....:          ...||....|||.||:
Mouse   286 A----RQLFVSYTV----------QLGTPDFVIPLPEVDI 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDZ-GEF	NP_609012.2	CAP_ED	128..237	CDD:237999
		RasGEFN	279..400	CDD:214571
		PDZ_signaling	404..494	CDD:238492
		DegQ	<422..494	CDD:223343
		PDZ_GEF_RA	757..841	CDD:176380
		RasGEF	871..1050	CDD:279011
		Rhomboid_SP	1252..>1357	CDD:289371	24/104 (23%)
Gm3404	XP_011239299.1	REM	89..177	CDD:100121
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900