DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9222 and Sik3

DIOPT Version :9

Sequence 1:	NP_608999.2	Gene:	CG9222 / 33867	FlyBaseID:	FBgn0031784	Length:	337	Species:	Drosophila melanogaster
Sequence 2:	NP_081774.3	Gene:	Sik3 / 70661	MGIID:	2446296	Length:	1369	Species:	Mus musculus

Alignment Length:	299	Identity:	112/299 - (37%)
Similarity:	162/299 - (54%)	Gaps:	21/299 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 PPQPKPPAPSGVVPVKADDKSKPQKTILEEHGIILGKV--------IGTGNYAKVKIGFSEEYGK 100
            ||...|||....|| .|...::|  |.....|.:..::        ||.||:|.||.........
Mouse    29 PPAAGPPAAPAAVP-PAAVPARP--TAPASRGSMAARIGYYEIDRTIGKGNFAVVKRATHLVTKA 90

  Fly   101 RVAVKIISKVKAPSEYTQKFLPREIEAVKGLHHENLITFYQSIETSHRVYLIMQLAENGTLLDYV 165
            :||:|||.|.:...|..:|.. ||::.:|.|.|.::|..||.:||...:||:.:.|..|.:.|::
Mouse    91 KVAIKIIDKSQLDEENLKKIF-REVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHL 154

  Fly   166 RERKFLDEPQSRTLFKQLVSAVEYIHSKGVVHRDIKCENLLLDENWNLKLIDFGFARKDTRTSDN 230
            .....:.|.::|..|||:|:||.:.|.:.:||||:|.||||||.|.|:|:.||||:...|...
Mouse   155 VAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQ-- 217

  Fly   231 QVILSKTFCGSYAYASPEILKGVAYDPFMSDIWACGVVCYAMVFGRLPYDGSNVHILLKRINQSL 295
               |.||:|||..||:||:.:|..||....|||:.|||.|.:|.|.||:|||.:..|..|: .|.
Mouse   218 ---LLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARV-LSG 278

  Fly   296 VFPKSPSASSECKHMIMH--ILAPVKIRYNIPQVKEDPW 332
            .|......|:||:|:|.|  :|.|.| |.::.|:....|
Mouse   279 KFRIPFFMSTECEHLIRHMLVLDPNK-RLSMEQICRHKW 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9222	NP_608999.2	STKc_TSSK4-like	75..333	CDD:271064	102/268 (38%)
CG9222	NP_608999.2	S_TKc	78..332	CDD:214567	100/263 (38%)
Sik3	NP_081774.3	STKc_SIK	65..317	CDD:270973	101/260 (39%)
		S_TKc	66..317	CDD:214567	101/259 (39%)
		UBA_SIK3	346..390	CDD:270593
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910