Protein Alignment CG9222 and SIK1

DIOPT Version :10

• Sequence 1: NP_608999.2
• Gene: CG9222 / 33867
• FlyBaseID: FBgn0031784
• Length: 337
• Species: Drosophila melanogaster
• Sequence 2: NP_775490.2
• Gene: SIK1 / 150094
• HGNCID: 11142
• Length: 783
• Species: Homo sapiens
• Alignment Length: 255
• Identity: 96/255 - (37%)
• Similarity: 150/255 - (58%)
• Gaps: 10/255 - (3%)

  Fly    80 KVIGTGNYAKVKIGFSEEYGKRVAVKIISKVKAPSEYTQKFLPREIEAVKGLHHENLITFYQSIE 144
            :.:|.||:|.||:........:||:|||.|.:..|...:| :.||::.:|.|:|.::|..||.:|
Human    31 RTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEK-IYREVQLMKLLNHPHIIKLYQVME 94

  Fly   145 TSHRVYLIMQLAENGTLLDYVRERKFLDEPQSRTLFKQLVSAVEYIHSKGVVHRDIKCENLLLDE 209
            |...:|::.:.|:||.:.||:.....|.|.::|..|.|::|||||.|...:||||:|.||||||.
Human    95 TKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDG 159

  Fly   210 NWNLKLIDFGFARKDTRTSDNQVILSKTFCGSYAYASPEILKGVAYDPFMSDIWACGVVCYAMVF 274
            |.::||.||||.  :...|...:   .|:|||..||:||:.:|..|:....|||:.|||.|.:|.
Human   160 NMDIKLADFGFG--NFYKSGEPL---STWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVC 219

  Fly   275 GRLPYDGSNVHILLKRINQSLVFPKSPSASSECKHMI--MHILAPVKIRYNIPQVKEDPW 332
            |.||:||.|:..|.:|:.:.. |......|.:|:.:|  |.::.|.: |..|.|:::..|
Human   220 GSLPFDGPNLPTLRQRVLEGR-FRIPFFMSQDCESLIRRMLVVDPAR-RITIAQIRQHRW 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9222	NP_608999.2	STKc_TSSK4-like	75..333	CDD:271064	96/255 (38%)
SIK1	NP_775490.2	STKc_SIK	26..278	CDD:270973	96/255 (38%)
		UBA_SIK1	300..349	CDD:270591
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	353..377
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..477
		RK-rich region, required for cAMP responsiveness and nuclear localization. /evidence=ECO:0000305|PubMed:29211348	583..612
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	619..643