DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VSIG10L2 and hbs

DIOPT Version :9

Sequence 1:	NP_001352006.1	Gene:	VSIG10L2 / 338667	HGNCID:	27879	Length:	793	Species:	Homo sapiens
Sequence 2:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster

Alignment Length:	890	Identity:	187/890 - (21%)
Similarity:	294/890 - (33%)	Gaps:	293/890 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    49 GGSVELACGSGPA--PLLVLWSFT--PLGSLVPRPVAVTDGAMSKVEAIASALGVVSLRNSSLVL 109
            |.||:|:|.:.|:  ...:.||..  ||.:...:..:.:||            |.||..|.||.:
  Fly   360 GDSVQLSCVTAPSNPQARISWSINGRPLDNSTYKTTSSSDG------------GWVSSSNISLTI 412

Human   110 GELHEGARGHFLCQVLHVAGGQL--HAAYSHLTLAVLVPVSKPQVRLSNPSP--VEGASVVATCA 170
                 .::......|.|....:|  :...|| |:.||.|.|.|.:...|...  :.|:.:...|:
  Fly   413 -----DSQSRTFIAVCHALNTELTQNVVGSH-TVNVLYPPSPPLLTGYNDGDILISGSILKLQCS 471

Human   171 VREGTEPVTFAWQH-----RAPRGLGEALVGVTEPLFQLDPVNRTHLGWYMCSASNSVNRLSSDG 230
            ...|..|.|..|..     .||..|.::  .:|..|..|  ||        .|.:|::.:.....
  Fly   472 SAGGNPPPTLQWYKNDKIINAPSKLVDS--KITSELSLL--VN--------ASDNNAIYKCKVQN 524

Human   231 AFLD----------VIYGPDKPVITMEPLGLTEEGFWASEREEVTLSC-LAASNPPSHYVWLRDH 284
            |.:|          |.:.|:...|::.|..|. .|..|.      |.| .::||||:...|.:|.
  Fly   525 AAIDIPLFATKTLGVHFPPETVKISVVPKNLV-PGIRAK------LICDSSSSNPPAKISWWKDG 582

Human   285 TQVHTGPTYVIAR-----AGRVHT------------GL-YTCLARNSYLDTRTQTTVQLTIYYPP 331
            ..|.   ...:|.     .|.|.|            |: |||.:.|..|......|:.|.|.|||
  Fly   583 IPVE---GLNLANRPGLWGGSVSTLEMYVNITQDLDGIVYTCQSHNEVLQRSVHETISLDILYPP 644

Human   332 EGQPSCAVHPSPEAVTLLCAWPGGLPPAQLQWEGPQGPGPTAPSNV-------------TWSHAA 383
            :.:       :|::.|.:               |.:|    ||.:|             ||:...
  Fly   645 KFE-------TPQSTTFV---------------GVEG----APFHVELLASGNPMVITYTWTKDG 683

Human   384 AQLPSGSVFTCTGQHPALAPPALCTVMLWEPLGRPTCWSTATMGDQFIMLSCEWPGGEPPATLGW 448
            ..:.|.|:   :||......|.|..             |..:..|..:.: ||....:..|.|
  Fly   684 LPISSNSL---SGQRLISDGPRLNI-------------SRLSRNDAGVYI-CEALNSQGTALL-- 729

Human   449 LDEQQQPLGGSSSSMAVHLLQAQEDLAGREFTCRGTHLLRTPDPHCHLQ---LEAPQL------- 503
              |.|..:..:.:..||.        .||.|......:|.     ||:|   |||..:
  Fly   730 --EIQVAVEYAPTITAVS--------EGRSFVAGEPAVLA-----CHIQARPLEAAHVRWSRDGY 779

Human   504 DVAEPRVSVLEGGEAWLE-------------CSL--RGGTPPAQLLWLGPQ-QQKVD--PGTS-- 548
            |:|...:|..|.|.|.|:             |.:  :.|.|.||.:.|..| ..::|  ||.:
  Fly   780 DLATRTISSFENGTALLQIASVERSDIGNFTCIVDNQRGAPAAQNVLLVVQTAPEIDHSPGFTRY 844

Human   549 --------------------GFMLHPEGAQLR----------------------LGIYDADPAHH 571
                                .|:....|..|:                      |.|.:..|..:
  Fly   845 AARLGVRAQLICRSLASPQPSFIWRRHGKDLKMQRRNKFKSVERQVDALNFESALLIENTSPDDY 909

Human   572 RGTYQCVARNAVGNSSQSVLLEVLRYPAPPNVTISRLTYGRHRREVQLQWAILGPGNLTGFLVQR 636
             |.|:||.||::|.:|.:  ||..: |:.|:..:...........|.|.|.   ||...|.....
  Fly   910 -GQYECVVRNSLGQASTT--LEFSK-PSRPDAPLQLRVGNVSDTGVDLNWT---PGFDGGMQTYF 967

Human   637 KASALGPGAGAWETAASDIEPESRGRRLGGLDPGVLYAFRILALNH------------------- 682
            :......|...::..  |.:|..:...|.||.||..|.|.::|.|.
  Fly   968 RLRLKQHGEDKYKYV--DAKPGHQNISLDGLKPGATYYFSVMAANEAGGSKFMPDIKLTLSKGSQ 1030

Human   683 -HTAGHPSEVKIPADPPFSAYPAVLGAAGTGMVVATVASLLVFQYAARHPETFPRLGQLLVPTEQ 746
             |:|.:..:.::|       ...::|.....||:..:.:.||..:..|
  Fly  1031 PHSAEYTEKDELP-------NVMIIGITSAAMVLLVLNAALVAWFVIR----------------- 1071

Human   747 RHQQRGSREDAEAPAGLETPTTTPGLDPAQETTDSPVNVTITVTA 791
              :|..|:.:||           |..|......||.....:.:||
  Fly  1072 --RQNKSQSEAE-----------PSNDDVYSKDDSQSVYKLPITA 1103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VSIG10L2	NP_001352006.1	Ig_3	149..221	CDD:316449	17/78 (22%)
		Ig_3	241..312	CDD:316449	22/89 (25%)
		IG_like	508..594	CDD:214653	30/147 (20%)
		fn3	598..689	CDD:306538	22/110 (20%)
hbs	NP_001286439.1	Ig	44..122	CDD:299845
		IG_like	45..137	CDD:214653
		Ig	153..231	CDD:299845
		IG_like	258..342	CDD:214653
		Ig	266..327	CDD:299845
		IG_like	357..>414	CDD:214653	18/70 (26%)
		Ig	360..427	CDD:299845	20/83 (24%)
		Ig	<468..526	CDD:299845	15/69 (22%)
		I-set	547..633	CDD:254352	24/95 (25%)
		Ig	556..631	CDD:299845	21/84 (25%)
		I-set	644..735	CDD:254352	24/137 (18%)
		IGc2	668..725	CDD:197706	12/73 (16%)
		IG_like	751..829	CDD:214653	20/82 (24%)
		IGc2	753..815	CDD:197706	15/66 (23%)
		Ig	852..928	CDD:143165	14/78 (18%)
		FN3	935..1017	CDD:238020	19/86 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010