Protein Alignment tctn and TCTN1

DIOPT Version :10

• Sequence 1: NP_608998.2
• Gene: tctn / 33866
• FlyBaseID: FBgn0261697
• Length: 657
• Species: Drosophila melanogaster
• Sequence 2: NP_001076007.1
• Gene: TCTN1 / 79600
• HGNCID: 26113
• Length: 592
• Species: Homo sapiens
• Alignment Length: 594
• Identity: 127/594 - (21%)
• Similarity: 201/594 - (33%)
• Gaps: 184/594 - (30%)

  Fly     6 PLVVLCLATYHTHSIKIGISHNYNATISPTASTTTEAPATTGAPSSETVSSISTLPEAEVTTTTP 70
            ||:|:.|          |...:.:|....|.:.|||...:|.|    .:::..|.|    :|..|
Human     8 PLLVVLL----------GCWASVSAQTDATPAVTTEGLNSTEA----ALATFGTFP----STRPP 54

  Fly    71 AITFPPRVQQKPKVAVASPTMSTALPLNSTEVNSTLSVSGDNTFYYCSCDLQAGRCDLNCCCDND 135
            .....|.....|:     ||     |:....|             .|.|||...:||:|||||.|
Human    55 GTPRAPGPSSGPR-----PT-----PVTDVAV-------------LCVCDLSPAQCDINCCCDPD 96

  Fly   136 CPLETRQVFN-------------CLPNSLL---------PQLESRLEDFQYTHGLPTCQINDGWL 178
            |......||:             |...:::         ||....|.|          |||....
Human    97 CSSVDFSVFSACSVPVVTGDSQFCSQKAVIYSLNFTANPPQRVFELVD----------QINPSIF 151

  Fly   179 CVFRSNTKATKT-----QPPDMNIDTSQYRKWKDNLEYQESDYAQ-----SRPSAGHYKFGQTLQ 233
            |:..:|.|...:     .|.:.|.||  ..|..|........|..     ..|:|..|::|..||
Human   152 CIHITNYKPALSFINPEVPDENNFDT--LMKTSDGFTLNAESYVSFTTKLDIPTAAKYEYGVPLQ 214

  Fly   234 -----LWQPE--TKQLATLELPAAYESPNCQLKQSVWHLQPIRHVCRMKDSAQLQESIWSL-LNQ 290
                 |..|.  |..|.|...|||:     .:.|:|        .|..|.:.:..|.|.:| :..
Human   215 TSDSFLRFPSSLTSSLCTDNNPAAF-----LVNQAV--------KCTRKINLEQCEEIEALSMAF 266

  Fly   291 TSNYEILSKPRDLEEPEVNGLIVQVCLRGANKSMRCLERGNDTQL--DVIVDHVELQLIHNFTNI 353
            .|:.|||..|...::..:.  :..:.::..||:   |.|..||.:  ..:|:.....|..|.  :
Human   267 YSSPEILRVPDSRKKVPIT--VQSIVIQSLNKT---LTRREDTDVLQPTLVNAGHFSLCVNV--V 324

  Fly   354 LEAK---LFLEEAKLAEDDNE-----------PLWLRYNVEFVTLNESLTKPTSGPLGYLSGAPV 404
            ||.|   .:.:..::.:.|..           ||..::.:.|:..| :...|.||..||:.|.|:
Human   325 LEVKYSLTYTDAGEVTKADLSFVLGTVSSVVVPLQQKFEIHFLQEN-TQPVPLSGNPGYVVGLPL 388

  Fly   405 ILSRM------LPQNSSEDKQLISYHSLNQNIKEFHWLSLPSRKPRGSSCQRALDHKEALRFGID 463
            .....      :.|.::...||...||..:                 ..|......:..:.||..
Human   389 AAGFQPHKGSGIIQTTNRYGQLTILHSTTE-----------------QDCLALEGVRTPVLFGYT 436

  Fly   464 LLTRCELRHAAPLLQAHANHTEYCQGLQAQIWSLL---------LPHNCTQLEDVTKVFVSHLGR 519
            :.:.|:||....|         .||.:..::.|||         .|...:|.:|:.
Human   437 MQSGCKLRLTGAL---------PCQLVAQKVKSLLWGQGFPDYVAPFGNSQAQDML--------- 483

  Fly   520 PQPDKWLPM 528
                .|:|:
Human   484 ----DWVPI 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tctn	NP_608998.2	Herpes_BLLF1	<33..>112	CDD:282904	16/78 (21%)
		TCTN_DUF1619	117..403	CDD:462260	82/341 (24%)
TCTN1	NP_001076007.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	46..68		6/30 (20%)
		TCTN_DUF1619	78..387	CDD:462260	82/341 (24%)