Protein Alignment tctn and TCTN3

DIOPT Version :9

• Sequence 1: NP_608998.2
• Gene: tctn / 33866
• FlyBaseID: FBgn0261697
• Length: 657
• Species: Drosophila melanogaster
• Sequence 2: XP_011537929.1
• Gene: TCTN3 / 26123
• HGNCID: 24519
• Length: 620
• Species: Homo sapiens
• Alignment Length: 623
• Identity: 140/623 - (22%)
• Similarity: 217/623 - (34%)
• Gaps: 214/623 - (34%)

  Fly    43 PATTGAPSSETVSSI--------STLPE-AEVTTTTPAITFPPRVQQKPKVAVASPTMST-ALPL 97
            |..:.:||....:|:        .||.. :|.|.|.||:         |.:....||:.| :.|.
Human    40 PQPSSSPSGAVPTSLELQRGTDGGTLQSPSEATATRPAV---------PGLPTVVPTLVTPSAPG 95

  Fly    98 NST-EVNSTLSVSGDNTFYYCSCDLQAGRCDLNCCCDNDC-PLETRQVFN-CLPNSLLPQLESRL 159
            |.| ::...|.:        |.|||..|.||:|||||.|| .|..|.||: |||.|:.
Human    96 NRTVDLFPVLPI--------CVCDLTPGACDINCCCDRDCYLLHPRTVFSFCLPGSVR------- 145

  Fly   160 EDFQYTHGLPTCQINDGWLCV-----FRSNTKATKTQPPDMNIDTSQYRKW-----KDNLEY--- 211
                          :..|:||     ||||:..    |..:.:|::..|::     ..||.|
Human   146 --------------SSSWVCVDNSVIFRSNSPF----PSRVFMDSNGIRQFCVHVNNSNLNYFQK 192

  Fly   212 ---------------------QESDYAQSRPSAGHYKFGQTLQLWQPETKQLATLELPAAYESPN 255
                                 ..:...||.||  .|:.|..:..:.|:...::.|..||...:..
Human   193 LQKVNATNFQALAAEFGGESFTSTFQTQSPPS--FYRAGDPILTYFPKWSVISLLRQPAGVGAGG 255

  Fly   256 -CQLKQSVWHLQPIRHVC-----RMKDSAQLQESIWSLLNQTS--NYEILSKPRDLEEPEVNGLI 312
             |........|:.....|     .:..|..|.    |.||..|  |:.:|..||.:.:|:.....
Human   256 LCAESNPAGFLESKSTTCTRFFKNLASSCTLD----SALNAASYYNFTVLKVPRSMTDPQNMEFQ 316

  Fly   313 VQVCLRGANKSMRCLERGNDTQLDVIVDHVELQLIHNFT-NILEAKLFLEEAKLAEDDNEPLWLR 376
            |.|.|  .:::...|..||..|  .:|..|..::..|.| .|.:..:.|.:..|..:....|...
Human   317 VPVIL--TSQANAPLLAGNTCQ--NVVSQVTYEIETNGTFGIQKVSVSLGQTNLTVEPGASLQQH 377

  Fly   377 YNVEFVTLNE----SLTKPTSGPLGYLSGAPVILSRMLPQNSSEDKQLISYHSLNQNIKEFHWLS 437
            :.:.|....:    |||.|.||..||:.|.|::.       .::|   |||.|..
Human   378 FILRFRAFQQSTAASLTSPRSGNPGYIVGKPLLA-------LTDD---ISYSSQG---------- 422

  Fly   438 LPSRKPRGSSCQRALDHKEALRFGIDLLTRCELR-----------------HAAP---------- 475
                   ..||.   ..:..::||::.::.|:||                 |..|
Human   423 -------NGSCS---VKRHEVQFGVNAISGCKLRLKKADCSHLQQEIYQTLHGRPRPEYVAIFGN 477

  Fly   476 -----------LLQAHA-----NHTEYC--------------QGL----QAQIWSLLLPHNCTQL 506
                       :|..|.     |.|..|              .||    ||.:..:...:.|..:
Human   478 ADPAQKGGWTRILNRHCSISAINCTSCCLIPVSLEIQVLWAYVGLLSNPQAHVSGVRFLYQCQSI 542

  Fly   507 ED---VTKV-------FVSHLGRPQPDKWLP-MEVRYP 533
            :|   ||:|       ||....:|||.:..| |:.::|
Human   543 QDSQQVTEVSLTTLVNFVDITQKPQPPRGQPKMDWKWP 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tctn	NP_608998.2	DUF1619	117..403	CDD:285068	84/334 (25%)
TCTN3	XP_011537929.1	DUF1619	108..408	CDD:285068	84/334 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I10142
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	70	1.000	Inparanoid score	I5319
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004997
OrthoInspector	1	1.000	-	-		oto91827
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14611
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4779
SonicParanoid	1	1.000	-	-		X4647
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	9.090