Protein Alignment tctn and TCTN3

DIOPT Version :10

• Sequence 1: NP_608998.2
• Gene: tctn / 33866
• FlyBaseID: FBgn0261697
• Length: 657
• Species: Drosophila melanogaster
• Sequence 2: NP_056446.4
• Gene: TCTN3 / 26123
• HGNCID: 24519
• Length: 607
• Species: Homo sapiens
• Alignment Length: 623
• Identity: 140/623 - (22%)
• Similarity: 221/623 - (35%)
• Gaps: 209/623 - (33%)

  Fly    43 PATTGAPSSETVSSI--------STLPE-AEVTTTTPAITFPPRVQQKPKVAVASPTMST-ALPL 97
            |..:.:||....:|:        .||.. :|.|.|.||:         |.:....||:.| :.|.
Human    22 PQPSSSPSGAVPTSLELQRGTDGGTLQSPSEATATRPAV---------PGLPTVVPTLVTPSAPG 77

  Fly    98 NST-EVNSTLSVSGDNTFYYCSCDLQAGRCDLNCCCDNDC-PLETRQVFN-CLPNSLLPQLESRL 159
            |.| ::...|.:        |.|||..|.||:|||||.|| .|..|.||: |||.|:.
Human    78 NRTVDLFPVLPI--------CVCDLTPGACDINCCCDRDCYLLHPRTVFSFCLPGSVR------- 127

  Fly   160 EDFQYTHGLPTCQINDGWLCV-----FRSNTKATKTQPPDMNIDTSQYRKW-----KDNLEY--- 211
                          :..|:||     ||||:..    |..:.:|::..|::     ..||.|
Human   128 --------------SSSWVCVDNSVIFRSNSPF----PSRVFMDSNGIRQFCVHVNNSNLNYFQK 174

  Fly   212 ---------------------QESDYAQSRPSAGHYKFGQTLQLWQPETKQLATLELPAAYESPN 255
                                 ..:...||.||  .|:.|..:..:.|:...::.|..||...:..
Human   175 LQKVNATNFQALAAEFGGESFTSTFQTQSPPS--FYRAGDPILTYFPKWSVISLLRQPAGVGAGG 237

  Fly   256 -CQLKQSVWHLQPIRHVC-----RMKDSAQLQESIWSLLNQTS--NYEILSKPRDLEEPEVNGLI 312
             |........|:.....|     .:..|..|.    |.||..|  |:.:|..||.:.:|:.....
Human   238 LCAESNPAGFLESKSTTCTRFFKNLASSCTLD----SALNAASYYNFTVLKVPRSMTDPQNMEFQ 298

  Fly   313 VQVCLRGANKSMRCLERGNDTQLDVIVDHVELQLIHNFT-NILEAKLFLEEAKLAEDDNEPLWLR 376
            |.|.|  .:::...|..||..|  .:|..|..::..|.| .|.:..:.|.:..|..:....|...
Human   299 VPVIL--TSQANAPLLAGNTCQ--NVVSQVTYEIETNGTFGIQKVSVSLGQTNLTVEPGASLQQH 359

  Fly   377 YNVEFVTLNE----SLTKPTSGPLGYLSGAPVILSRMLPQNSSEDKQLISYHSLNQNIKEFHWLS 437
            :.:.|....:    |||.|.||..||:.|.|::.       .::|   |||.           ::
Human   360 FILRFRAFQQSTAASLTSPRSGNPGYIVGKPLLA-------LTDD---ISYS-----------MT 403

  Fly   438 LPSRKPRGSSCQRALDHKEALRFGIDLLTRCELR-----------------HAAP---------- 475
            |...:..||...:    :..::||::.::.|:||                 |..|
Human   404 LLQSQGNGSCSVK----RHEVQFGVNAISGCKLRLKKADCSHLQQEIYQTLHGRPRPEYVAIFGN 464

  Fly   476 -----------LLQAHA-----NHTEYC--------------QGL----QAQIWSLLLPHNCTQL 506
                       :|..|.     |.|..|              .||    ||.:..:...:.|..:
Human   465 ADPAQKGGWTRILNRHCSISAINCTSCCLIPVSLEIQVLWAYVGLLSNPQAHVSGVRFLYQCQSI 529

  Fly   507 ED---VTKV-------FVSHLGRPQPDKWLP-MEVRYP 533
            :|   ||:|       ||....:|||.:..| |:.::|
Human   530 QDSQQVTEVSLTTLVNFVDITQKPQPPRGQPKMDWKWP 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tctn	NP_608998.2	Herpes_BLLF1	<33..>112	CDD:282904	19/79 (24%)
		TCTN_DUF1619	117..403	CDD:462260	84/334 (25%)
TCTN3	NP_056446.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	21..60		10/37 (27%)
		TCTN_DUF1619	90..390	CDD:462260	84/334 (25%)