DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment WDR79 and WRAP53

DIOPT Version :9

Sequence 1:	NP_001285665.1	Gene:	WDR79 / 33865	FlyBaseID:	FBgn0031782	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001137462.1	Gene:	WRAP53 / 55135	HGNCID:	25522	Length:	548	Species:	Homo sapiens

Alignment Length:	528	Identity:	186/528 - (35%)
Similarity:	263/528 - (49%)	Gaps:	78/528 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 ASMLNHNVSFSSTM--VTSNGDLSLPKLSVTLSAEEIL--KLRSGRPKNAVESP---HAGVPME- 111
            ||.:|.|.. |..|  ....||  .|:||....|...:  :||.|.|. ::.:|   ..|.|.|
Human    29 ASPMNKNAD-SELMPPPPERGD--PPRLSPDPVAGSAVSQELREGDPV-SLSTPLETEFGSPSEL 89

  Fly   112 ------------TSLAAEEEANGDEEEESVRVVDIEDTLELTSNGNEAKPEDQ-----ELAIAPV 159
                        |||.| |||||...||.....::.....:.....|...||:     ..:.:.:
Human    90 SPRIEEQELSENTSLPA-EEANGSLSEEEANGPELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQL 153

  Fly   160 LQYFQGALVELGRRCWTS-STEAQHYTKGCYWSPDGTCLLVPVHLDGMHVIEMPSDLY-SADTVQ 222
            .::..|:        |:. ||:.:::.|||.|:|||:|:|.....:.:.:..:|.:|| ..:.|:
Human   154 PRFLSGS--------WSEFSTQPENFLKGCKWAPDGSCILTNSADNILRIYNLPPELYHEGEQVE 210

  Fly   223 PARSLTKLQSEVHVPEGGTVYDCVWYPHMNSLQPETCLWLATRQHEPIHMWDAFDGSLRCSYSGY 287
            .|..:..|:    :.||.|:||..||..|:|.||:|....::.:..|||:||||.|.||.|:..|
Human   211 YAEMVPVLR----MVEGDTIYDYCWYSLMSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAY 271

  Fly   288 DAVDEVMAAISLAFSHDGEQIYAGYKRCIKIFDTSRPGRFCDDYPVKFA--------ISCIAQTT 344
            :.:||:.||.||.||.||.|::.|:.|.:::|.|:||||.| :....||        |||||.:.
Human   272 NHLDELTAAHSLCFSPDGSQLFCGFNRTVRVFSTARPGRDC-EVRATFAKKQGQSGIISCIAFSP 335

  Fly   345 AHPHTLTCGNWHGYIQHFDLRCSHKQGPLFTLGGHKGGITQLRYGEFGNGEWHLFSGARKCDKIL 409
            |.| ...||:   |.:...|.......||..||||:||||.|.:...||   ..||||||..::|
Human   336 AQP-LYACGS---YGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGN---RFFSGARKDAELL 393

  Fly   410 QWDMRNYKQPLVELQRHVDTNQRIQFDLASDSNWLASGDTRGFVNVWDLKKYGDP-------SVL 467
            .||:|....||..|.|.|.|||||.|||.....:|.||.|.|.|:|||....|:.       |.|
Human   394 CWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFL 458

  Fly   468 PLHSDCCNGVALNPAMPILATSSGQFHFTDQSAQGDNVTLNGTETTELPAPADVNQNQKEVLYEN 532
            | ..||.|||:|:|::|:|||:|||..|.:.:..||       |..||..|.   .:.:.|..|.
Human   459 P-QKDCTNGVSLHPSLPLLATASGQRVFPEPTESGD-------EGEELGLPL---LSTRHVHLEC 512

  Fly   533 AVVMWWCG 540
            .:.:||||
Human   513 RLQLWWCG 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WDR79	NP_001285665.1	WD40	<273..490	CDD:330360	102/231 (44%)
		WD40 repeat	294..332	CDD:293791	18/37 (49%)
		WD40 repeat	337..377	CDD:293791	13/39 (33%)
		WD40 repeat	384..424	CDD:293791	16/39 (41%)
		WD40 repeat	433..466	CDD:293791	14/39 (36%)
WRAP53	NP_001137462.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..142		34/117 (29%)
		WD 1. /evidence=ECO:0000255	167..206		12/38 (32%)
		WD40	175..480	CDD:421866	130/317 (41%)
		WD40 repeat	175..223	CDD:293791	13/51 (25%)
		WD 2. /evidence=ECO:0000255	222..267		22/44 (50%)
		WD40 repeat	227..273	CDD:293791	21/45 (47%)
		WD 3. /evidence=ECO:0000255	272..313		20/41 (49%)
		WD40 repeat	280..319	CDD:293791	17/39 (44%)
		WD 4. /evidence=ECO:0000255	323..364		13/44 (30%)
		WD40 repeat	329..364	CDD:293791	12/38 (32%)
		WD 5. /evidence=ECO:0000255	365..405		20/42 (48%)
		WD40 repeat	370..410	CDD:293791	18/42 (43%)
		WD 6. /evidence=ECO:0000255	411..450		19/38 (50%)
		WD40 repeat	418..456	CDD:293791	13/37 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..548
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145967
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2919
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9995
Inparanoid	1	1.050	254	1.000	Inparanoid score	I3201
Isobase	1	0.950	-	0	Normalized mean entropy	S5141
OMA	1	1.010	-	-		QHG48389
OrthoDB	1	1.010	-	-		D319634at33208
OrthoFinder	1	1.000	-	-		FOG0005823
OrthoInspector	1	1.000	-	-		oto88538
orthoMCL	1	0.900	-	-		OOG6_102801
Panther	1	1.100	-	-	LDO	PTHR13211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4109
SonicParanoid	1	1.000	-	-		X4799
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750