DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment WDR79 and gnr1

DIOPT Version :9

Sequence 1:	NP_001285665.1	Gene:	WDR79 / 33865	FlyBaseID:	FBgn0031782	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_587950.1	Gene:	gnr1 / 2539303	PomBaseID:	SPCC1020.09	Length:	399	Species:	Schizosaccharomyces pombe

Alignment Length:	326	Identity:	90/326 - (27%)
Similarity:	140/326 - (42%)	Gaps:	34/326 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 SSTEAQHYTKGCYWSPDGTCLLVPVHLDGMHVIEMP-SDLYSADTVQPARSLTKLQSEVHVPEGG 240
            |.|:..::.....|||||:.:|.......::...:| ||| |.....|......|..:...||
pombe    41 SPTKPLNFFHSSRWSPDGSTILSLTEDQCLNCWNVPFSDL-SKKADGPLNFSKHLSYKYQSPE-- 102

  Fly   241 TVYDCVWYPHMNSLQPETCLWLATRQHEPIHMWDAFDGSLRCSYSGYDAVDEVMAAISLAFSHDG 305
            |||...||..|....|.:.|:..:.:.:||.:.:...|..:.||...|..:....:..|.|::||
pombe   103 TVYSYSWYSRMKLDDPSSNLFAVSSRDQPIKLINFTTGKNKASYHMIDHQERYQGSHCLQFTNDG 167

  Fly   306 EQIYAGYKRCIKIFDTSRPGRFCD----------------DYPVKFAISCIAQTTAHPHTLTCGN 354
            |.:.||.|.|:..|:. |.|  |.                ::.:|...||.:.......||..|.
pombe   168 EYLIAGDKNCLHHFNI-RTG--CKEPVMTTVTHGYKVPLWEFSLKGIQSCFSLNPMDSKTLAVGT 229

  Fly   355 WHGYIQHFDLRCSHKQGPL-FTLGGHKG-GITQLRYGEFGNGEWHLFSGARKCDKILQWDMRNYK 417
            :...:..:: .|..:...| |::  .:| |:|.|::.|.|.   .|:.|:|..|||..||:|..:
pombe   230 YSNRVGIYN-DCGRRPCQLEFSI--ERGNGVTHLQWCEDGE---KLYVGSRCSDKIEVWDIRYVR 288

  Fly   418 QPLVELQRH-VDTNQRIQFDLASDSNWLASGDTRGFVNVWDLKKYGDPSVLPLHSD-CCNGVALN 480
            ..:..|:.| .||||||.||.......||.| |.|.:..|..|...:.:.:..:.| ..|.|..|
pombe   289 DMVYALEGHRGDTNQRILFDTDKKDEILAGG-TDGSIRRWRNKDLVEETHVTGNYDLTVNTVQAN 352

  Fly   481 P 481
            |
pombe   353 P 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WDR79	NP_001285665.1	WD40	<273..490	CDD:330360	63/229 (28%)
		WD40 repeat	294..332	CDD:293791	13/53 (25%)
		WD40 repeat	337..377	CDD:293791	8/40 (20%)
		WD40 repeat	384..424	CDD:293791	13/39 (33%)
		WD40 repeat	433..466	CDD:293791	10/32 (31%)
gnr1	NP_587950.1	WD40	47..>369	CDD:225201	88/320 (28%)
		WD40	53..328	CDD:295369	81/287 (28%)
		WD40 repeat	54..98	CDD:293791	13/44 (30%)
		WD40 repeat	105..150	CDD:293791	11/44 (25%)
		WD40 repeat	157..193	CDD:293791	13/38 (34%)
		WD40 repeat	212..250	CDD:293791	7/38 (18%)
		WD40 repeat	257..295	CDD:293791	13/40 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	85	1.000	Domainoid score	I2193
eggNOG	1	0.900	-	-		E1_KOG2919
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	85	1.000	Inparanoid score	I1795
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005823
OrthoInspector	1	1.000	-	-		oto100529
orthoMCL	1	0.900	-	-		OOG6_102801
Panther	1	1.100	-	-	LDO	PTHR13211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4109
SonicParanoid	1	1.000	-	-		X4799
TreeFam	0	0.000	Not matched by this tool.
	11	10.890