DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment WDR79 and tcab-1

DIOPT Version :9

Sequence 1:	NP_001285665.1	Gene:	WDR79 / 33865	FlyBaseID:	FBgn0031782	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001367010.1	Gene:	tcab-1 / 173303	WormBaseID:	WBGene00013669	Length:	449	Species:	Caenorhabditis elegans

Alignment Length:	488	Identity:	110/488 - (22%)
Similarity:	177/488 - (36%)	Gaps:	127/488 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 ASMLNHNVSFSSTMVTSNGDLSLPKLSVTLSA--EEI-LKLRSGRPKNAVESPHAGVPMETSLAA 116
            ||:|:   |..|..:.|..|    :||.|.:|  ||| .::...||.|..|........|.....
Worm    27 ASLLS---SLRSDHLASKID----ELSTTEAAASEEIPEEIPENRPLNRKEKRKLQRMQEIDQEV 84

  Fly   117 EEEANGDEEEESVRVVDIEDTLELTSNGNEAKPEDQELAIAPVLQYFQGALVELGRRCWTSSTEA 181
            :::|     :|.|.:.:|...|:.|......               |.....:.|.:    |||.
Worm    85 KKKA-----QEPVEIAEIPTNLKNTFCDKAT---------------FNSYNAQFGYK----STEN 125

  Fly   182 QHYTKGCYWSPDGTCLLVPVHLDGMHVIEMPSDLYSADTVQPARSLTKLQSEV-------HVPEG 239
            .::                ||             :|....|..|:|...|...       ..||
Worm   126 NNF----------------VH-------------FSIQNEQGNRALVASQDRFIRMYKIDETPE- 160

  Fly   240 GTVYDCVWYPHMNSLQPETCLW-------LATRQHEPIHMWDAFDGSLRCSYSGYDAVDEVMAAI 297
                 .:|..:..:|..::| |       .::.:..||.::|..:||:..:|:|.||.|.:.||:
Worm   161 -----VIWKHNTGNLVLDSC-WENSGKGVFSSSKLRPIQLFDTENGSILGAYNGKDAGDNITAAM 219

  Fly   298 SLAFSHDGEQIYAGYKRCIKIFDTSRPG-------RFCDDYPVKFAISCIAQTTAHPHTLT---- 351
            |:..|  |..:..|:|...:|:|....|       .|.:||.        ..||..|.::|
Worm   220 SIGQS--GSSLIGGFKNKFQIWDIEYTGDAIQHIKSFDNDYN--------TGTTGLPMSITPHPT 274

  Fly   352 ------CGNWHGYIQHFDLRCSHKQGPLFTLGGHKGGITQLRYGEFGNGEWHLFSGARKCDKILQ 410
                  .|.....:..:.|:.   :..:.|:.|...|.|.|.:...|   ..|::..||.| |..
Worm   275 MPDLFAAGGSSSLVAIYSLKW---RNAVSTIEGSLKGYTNLHFSPDG---LKLYASERKGD-IHC 332

  Fly   411 WDMRNYKQPLVELQRHVDTNQRIQFDLASDSNWLASGDTRGFVNVWDLKKYGDPSVLPLH----- 470
            :|.|......: |:|.:....|.:|.:......|.||.:.|.|.|:||.:|.: .:.|.|
Worm   333 FDTRMNMLTQI-LKRDMTATHRTRFSIDKSGRLLFSGTSGGDVIVYDLHEYSE-ELQPAHVQNVA 395

  Fly   471 SDCCNGVALNPAMPILATSSGQFHFTDQSAQGD 503
            |.|...|.|.....:|.  ||:..:.|....||
Worm   396 SRCVPCVDLKGKKLVLC--SGERVYPDDKLLGD 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WDR79	NP_001285665.1	WD40	<273..490	CDD:330360	60/238 (25%)
		WD40 repeat	294..332	CDD:293791	12/44 (27%)
		WD40 repeat	337..377	CDD:293791	7/49 (14%)
		WD40 repeat	384..424	CDD:293791	10/39 (26%)
		WD40 repeat	433..466	CDD:293791	10/32 (31%)
tcab-1	NP_001367010.1	WD40	<137..378	CDD:421866	62/265 (23%)
		WD40 repeat	172..208	CDD:293791	8/36 (22%)
		WD40 repeat	213..259	CDD:293791	13/47 (28%)
		WD40 repeat	267..303	CDD:293791	4/38 (11%)
		WD40 repeat	310..345	CDD:293791	10/39 (26%)
		WD40 repeat	353..379	CDD:293791	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158760
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2919
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005823
OrthoInspector	1	1.000	-	-		oto20512
orthoMCL	1	0.900	-	-		OOG6_102801
Panther	1	1.100	-	-	LDO	PTHR13211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4109
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.730