DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9175 and STL2P

DIOPT Version :9

Sequence 1:	NP_608995.2	Gene:	CG9175 / 33862	FlyBaseID:	FBgn0031779	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	NP_178256.1	Gene:	STL2P / 814675	AraportID:	AT2G01470	Length:	393	Species:	Arabidopsis thaliana

Alignment Length:	476	Identity:	106/476 - (22%)
Similarity:	184/476 - (38%)	Gaps:	145/476 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TRRPSDGLLARVNFPLYAVDML---------------------------TSRH-ILVAGGGGSSK 40
            |.:||:  :.....|:||.|.:                           :||. |:::||||..:
plant     8 TNQPSN--MQTYGVPIYAADWIPEVDVRSKIIMDPEKSEDDDESSSSSSSSRSCIVLSGGGGEGR 70

  Fly    41 TGVANGFEIYELYHNGSHFCAEEVLRHETGANVVMNFAV--RNGGRRGYLCAGQEAHCQMYYVQP 103
            :|::|...|..:..|.:....:.:.|...|:::....||  |.|   |.:||...: |::::.:.
plant    71 SGISNVILICRVDLNTNSLSEQPLGRLVVGSDLPYRMAVHPREG---GLICALPNS-CKLFHWED 131

  Fly   104 RVQSEEDGNGNGVGVGDGKPAPEERPHENGNVRQRNAHSGVEPVANGHRPPLSTADILRQFRRLH 168
             :.|.||   |..|                                      .:.:::::.|
plant   132 -IMSRED---NQAG--------------------------------------ESEEVIKELR--- 151

  Fly   169 FDIQAADVIQTDFLKGAEPLQRVVRISGNGRLMATGGTDGKLRVWTFPQM-TLAAELAAHSKEID 232
                  ||.|          |..:..:..|.::|.|..||.|||:.:|.| ||..|..||| .:.
plant   152 ------DVGQ----------QLALAFNPEGSVLAAGAEDGTLRVFKWPSMNTLLNESQAHS-SVK 199

  Fly   233 DLDFSPDSKLIASISKDAQGLVWDLASGQLQHKLQWKTPEGAKYLFKRCRYGTVEAQKDNYRLFT 297
            .|.||...:.:.|:.... ..|||:.:......|..:..|    :|..||:....|  .|..|:.
plant   200 CLTFSESGQFLVSLGGPV-CRVWDVNASAAVASLSKEKDE----MFASCRFSVDSA--GNEVLYI 257

  Fly   298 IANPLGKVGKQRG----------FLQHWDCASGQLRQAVAIDESLSSLAVRDDGRFVAVGTMFSG 352
            .||      .:||          :.:.|   |..:::     .|:|:..|..||:.:|:||: .|
plant   258 AAN------TERGGSIITCDTKLWKRKW---SKPIKK-----NSISAFNVSADGKLLAIGTL-EG 307

  Fly   353 SVSMYIAFSLQRVLHIPHAHSMFVTGLQFLPITNEEGPPISSDTEAAVLSISVDNKVCIHSLSQR 417
            .|.:..:..:|.:..:..||...||.|.|.|           |:...| |:|.|::..:..:.|:
plant   308 DVLILESTRMQTIQVVKKAHLGLVTALTFSP-----------DSRGLV-SVSFDSRARLTMIEQK 360

  Fly   418 RTIPA--WIAIVFLIVMIFAV 436
            ...|.  |..:|.|||:::.|
plant   361 GDKPGVRWWLLVLLIVLLYVV 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9175	NP_608995.2	WD40	<190..>421	CDD:225201	61/241 (25%)
		WD40	190..>420	CDD:295369	61/240 (25%)
		WD40 repeat	190..226	CDD:293791	13/36 (36%)
		WD40 repeat	231..267	CDD:293791	7/35 (20%)
		WD40 repeat	296..327	CDD:293791	6/40 (15%)
STL2P	NP_178256.1	WD40	77..>354	CDD:225201	82/376 (22%)
		WD40	<116..354	CDD:295369	73/334 (22%)
		WD40 repeat	158..193	CDD:293791	13/34 (38%)
		WD40 repeat	199..242	CDD:293791	10/47 (21%)
		WD40 repeat	245..281	CDD:293791	8/46 (17%)
		WD40 repeat	289..324	CDD:293791	10/35 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	52	1.000	Domainoid score	I4288
eggNOG	1	0.900	-	-		E1_KOG0771
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	71	1.000	Inparanoid score	I2456
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D828247at2759
OrthoFinder	1	1.000	-	-		FOG0004751
OrthoInspector	1	1.000	-	-		otm2484
orthoMCL	1	0.900	-	-		OOG6_104995
Panther	1	1.100	-	-	LDO	PTHR23284
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.830