DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9175 and mcl1

DIOPT Version :9

Sequence 1:	NP_608995.2	Gene:	CG9175 / 33862	FlyBaseID:	FBgn0031779	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	NP_594128.1	Gene:	mcl1 / 2543387	PomBaseID:	SPAPB1E7.02c	Length:	815	Species:	Schizosaccharomyces pombe

Alignment Length:	311	Identity:	63/311 - (20%)
Similarity:	105/311 - (33%)	Gaps:	91/311 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AHTRRPSDGL--LARVNFPLYAVDMLTSRHILVAGGGGSSKTGVANGFEIYELYHNGSHFCAEEV 64
            |||    |||  ||      |..|   .:.:|..|..           ::...:..||....:.:
pombe    11 AHT----DGLTRLA------YTRD---GKFLLTVGSN-----------QVIRKFQVGSDEEPDSI 51

  Fly    65 LRHE---TGANVVMNFAVRNGGRRGYLC-AGQEAHCQMYYVQ-------------PRVQSEEDGN 112
            ..|:   ||..|..|          |.| ..::|...:|.:.             |........:
pombe    52 DNHQDPITGIAVAEN----------YFCTCSEDATVCVYPIDSPTEHTLLARTTLPIRDVAYSVD 106

  Fly   113 GNGVGVGDGKPAPEE------------RPHENGNVRQRNAHSGVEPVANGHRPPLSTADILRQFR 165
            ||.:.:...:.|.:.            ||     .:..|.|....|  ||:...:|:.:.:..|
pombe   107 GNWIAIASDETAVKVVSSTDSSQIFSLRP-----AKASNKHVTYSP--NGNFLAVSSCNGILYF- 163

  Fly   166 RLHFDIQAADVIQ--TDFLKGAEPLQRVVRISG----NGRLMATGGTDGKLRV-----WTFPQMT 219
               :|.|..::|:  |:.:...|....:...:.    || ..|...||..:.|     |......
pombe   164 ---YDTQTRELIKFLTNTIASLEAESEICSKAAWHPKNG-TFAVASTDHFVSVISPDDWLPLYKL 224

  Fly   220 LAAELAAHSKEIDDLDFSPDSKLIASISKDAQGLVWDLASGQLQHKLQWKT 270
            |..|  .|| .:.|:.:|.:...||:..|....|:||..|.::..:|.:.|
pombe   225 LPKE--NHS-GVTDISWSSNGMYIAASFKKGGILIWDTQSHEVVVELPYST 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9175	NP_608995.2	WD40	<190..>421	CDD:225201	22/90 (24%)
		WD40	190..>420	CDD:295369	22/90 (24%)
		WD40 repeat	190..226	CDD:293791	9/44 (20%)
		WD40 repeat	231..267	CDD:293791	9/35 (26%)
		WD40 repeat	296..327	CDD:293791
mcl1	NP_594128.1	WD40	<11..269	CDD:225201	61/306 (20%)
		WD40	12..285	CDD:295369	62/310 (20%)
		WD40 repeat	16..53	CDD:293791	9/56 (16%)
		WD40 repeat	59..93	CDD:293791	8/43 (19%)
		WD40 repeat	98..132	CDD:293791	3/33 (9%)
		WD40 repeat	141..176	CDD:293791	9/40 (23%)
		WD40 repeat	188..225	CDD:293791	7/37 (19%)
		WD40 repeat	233..275	CDD:293791	11/40 (28%)
		Mcl1_mid	416..704	CDD:289138
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000