DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kr-h1 and ZBTB47

DIOPT Version :9

Sequence 1:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_660149.2	Gene:	ZBTB47 / 92999	HGNCID:	26955	Length:	747	Species:	Homo sapiens

Alignment Length:	518	Identity:	125/518 - (24%)
Similarity:	200/518 - (38%)	Gaps:	143/518 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 SGGQQEHFELLQTPQQRQMQLQLQDQH--QQEQQQFVSYQLAIQQHQKQQQQQQHE--------- 150
            ||.::|..|  :...|.:.:.:.:|.|  |:|:::....:...:|.|:..::::.|
Human   298 SGREEEEEE--EGGSQGEEEEEEEDGHSEQEEEEEEEEEEGPSEQDQESSEEEEGEEGEAGGKQG 360

  Fly   151 --------------------SITNAAPTAAPSAQRI------KTEPVGGFPASAAVVSQVRKPSA 189
                                |..||.....|..:..      :.:|..|..:::|     |.|.|
Human   361 PRGSRSSRADPPPHSHMATRSRENARRRGTPEPEEAGRRGGKRPKPPPGVASASA-----RGPPA 420

  Fly   190 S-----------KPQFKCDQCGMTFGSKSAHTSHTK-SHSKNQ-------------DLSLNGASG 229
            :           |....|.:|...|.::.....|.. :||:.|             :|.|:..:.
Human   421 TDGLGAKVKLEEKQHHPCQKCPRVFNNRWYLEKHMNVTHSRMQICDQCGKRFLLESELLLHRQTD 485

  Fly   230 AGVAAPVSTAAIELNDAGLPVG--IPKSPTIKPLANVAAG--ADPYQCNVCQKTFAVPARLIRHY 290
            .           |.|...:..|  ..|..::.....:..|  ...:.|.:|:|.|...|.:.:|.
Human   486 C-----------ERNIQCVTCGKAFKKLWSLHEHNKIVHGYAEKKFSCEICEKKFYTMAHVRKHM 539

  Fly   291 RTHTGERPFECEFCHKLFSVKENLQVHRRIHTKERPYKCDVCGRAFEHSGKLHRHMRIHTGERPH 355
            ..||.:.||.||.|.|.|....:|:||...|:.|:|::|:.|...|::..:|..||.||.|.:..
Human   540 VAHTKDMPFTCETCGKSFKRSMSLKVHSLQHSGEKPFRCENCNERFQYKYQLRSHMSIHIGHKQF 604

  Fly   356 KCSVCEKTFIQSGQLVIHMRTHTGEKPYKCPEPGCGKGFTCSKQLKVHSRTHTGEKPYHCDICFR 420
            .|..|.|.|........||:||||||||.|..  |||.||....:|.|.|||||||||.||:|.:
Human   605 MCQWCGKDFNMKQYFDEHMKTHTGEKPYICEI--CGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQ 667

  Fly   421 DFGYNHVLKLHRVQHYGSKCYKCTICDETFKNKKEMEAHIKGHANEVPDDEAEAAAASAAASTSA 485
            .|.::::||.|:     .||::                                     .:.|.|
Human   668 RFRFSNMLKAHK-----EKCFR-------------------------------------VSHTLA 690

  Fly   486 GSSAGSPSLQGVSSNSESSNHSPPSSPPATKKPRQARQPRVSKTVAATLSIPTSSPLSPSSLS 548
            |.  |.|:..|:          ||:.|.|...|   ..|.:.:|:.....:|...||.|::.|
Human   691 GD--GVPAAPGL----------PPTQPQAHALP---LLPGLPQTLPPPPHLPPPPPLFPTTAS 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	4/20 (20%)
		COG5048	<270..420	CDD:227381	64/149 (43%)
		zf-C2H2	271..293	CDD:278523	6/21 (29%)
		C2H2 Zn finger	273..293	CDD:275368	6/19 (32%)
		zf-H2C2_2	286..309	CDD:290200	9/22 (41%)
		C2H2 Zn finger	301..321	CDD:275368	8/19 (42%)
		zf-H2C2_2	313..338	CDD:290200	9/24 (38%)
		C2H2 Zn finger	329..349	CDD:275368	6/19 (32%)
		zf-H2C2_2	344..366	CDD:290200	9/21 (43%)
		C2H2 Zn finger	357..377	CDD:275368	6/19 (32%)
		zf-H2C2_2	370..396	CDD:290200	15/25 (60%)
		C2H2 Zn finger	385..407	CDD:275368	9/21 (43%)
		zf-H2C2_2	400..424	CDD:290200	15/23 (65%)
		C2H2 Zn finger	415..435	CDD:275368	7/19 (37%)
		zf-C2H2	441..463	CDD:278523	0/21 (0%)
		C2H2 Zn finger	443..463	CDD:275368	0/19 (0%)
ZBTB47	NP_660149.2	BTB	4..110	CDD:279045
		BTB	18..113	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	243..424		22/132 (17%)
		C2H2 Zn finger	438..459	CDD:275368	4/20 (20%)
		C2H2 Zn finger	465..484	CDD:275368	2/18 (11%)
		C2H2 Zn finger	492..512	CDD:275368	2/19 (11%)
		COG5048	520..>601	CDD:227381	29/80 (36%)
		C2H2 Zn finger	522..542	CDD:275368	6/19 (32%)
		zf-H2C2_2	534..559	CDD:290200	10/24 (42%)
		C2H2 Zn finger	550..570	CDD:275368	8/19 (42%)
		zf-H2C2_2	562..585	CDD:290200	8/22 (36%)
		cxxc_20_cxxc	577..>621	CDD:274982	13/43 (30%)
		C2H2 Zn finger	578..598	CDD:275368	6/19 (32%)
		C2H2 Zn finger	606..626	CDD:275368	6/19 (32%)
		zf-H2C2_2	618..643	CDD:290200	15/26 (58%)
		COG5048	630..>701	CDD:227381	35/126 (28%)
		C2H2 Zn finger	634..654	CDD:275368	9/21 (43%)
		zf-H2C2_2	646..669	CDD:290200	14/22 (64%)
		C2H2 Zn finger	662..678	CDD:275368	6/15 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..747		14/58 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000