DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kr-h1 and ZNF835

DIOPT Version :9

Sequence 1:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_001005850.2	Gene:	ZNF835 / 90485	HGNCID:	34332	Length:	537	Species:	Homo sapiens

Alignment Length:	537	Identity:	149/537 - (27%)
Similarity:	207/537 - (38%)	Gaps:	104/537 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 KAVAVKKSPAKDSATTKMVYYSANQLLIKTEQSSQAQFCLQVPPPLTATTTSVGLGVPPSGGQQE 102
            :|||.|..||.||             :.:.::.|:....:..|   .||..|    ||.....:.
Human    38 EAVACKGDPAGDS-------------MQERDEFSRIPRTISSP---AATQAS----VPDDSSSRR 82

  Fly   103 HFELLQTPQQRQMQLQLQDQHQQEQ-------------QQFVSYQLAIQQHQKQQQQQQHESITN 154
            .....::|::|.     .|..|:|:             .:..||..|...||:..        |.
Human    83 CSAPGESPKERH-----PDSRQRERGGGPKKPWKCGDCGKAFSYCSAFILHQRIH--------TG 134

  Fly   155 AAPTAAPSAQRIKTEPVGGFPASAAVVSQVRKPSASKPQFKCDQCGMTFGSKSAHTSHTKSHSKN 219
            ..|.|.|...:       .|..|..:....|..:..|| :.|.:||..|...|...||.::|:..
Human   135 EKPFACPECGK-------AFSQSVHLTLHQRTHTGEKP-YACHECGKAFSQGSYLASHWRTHTGE 191

  Fly   220 QDLSLNGASGAGVAAPVSTAAIELNDAGLPVGIPKSPTIKPLAN---------VAAGADPYQCNV 275
            :.........|.......|....::....|...  :...|...|         :..|..||:|:.
Human   192 KPHRCADCGKAFTRVTHLTQHRRVHTGERPYAC--AQCAKAFRNRSSLIEHQRIHTGEKPYECSA 254

  Fly   276 CQKTFAVPARLIRHYRTHTGERPFECEFCHKLFSVKENLQVHRRIHTKERPYKCDVCGRAFEHSG 340
            |.|.|...:.||||.|.||.|:|:.|..|.|.|:...:|..|||:||.|:||.|..||..|..|.
Human   255 CAKAFRFSSALIRHQRIHTEEKPYRCGQCAKAFAQIAHLTQHRRVHTGEKPYTCQDCGALFSQSA 319

  Fly   341 KLHRHMRIHTGERPHKCSVCEKTFIQSGQLVIHMRTHTGEKPYKCPEPG---------------- 389
            .|..|.||||||:|:.|..|.|.|.|...|..|.||||||:||.|.:.|
Human   320 SLAEHRRIHTGEKPYACGQCAKAFTQVSHLTQHQRTHTGERPYPCHDCGKRFSNRSHLLQHRLVH 384

  Fly   390 ----------CGKGFTCSKQLKVHSRTHTGEKPYHCDICFRDFGYNHVLKLHRVQHYGSKCYKCT 444
                      ||..|:....|..|.:.||||:||.|..|.:.|.....|.||:..|.|.:.|.|.
Human   385 TGERPYRCLQCGAAFSHVSSLIEHQKIHTGERPYKCGECGKAFSQGSSLALHQRTHTGERPYTCP 449

  Fly   445 ICDETFKNKKEMEAHIKGHANEVPDDEAEAAAASAAAS-------TSAGSS-----AGSP-SLQG 496
            .|.:.|.|:..:..|...|..|.|.:.:....|.:.:|       |.|.||     |.:| |..|
Human   450 ECGKAFSNRSYLIQHHIVHTGEKPYECSGCGKAFSFSSALIRHQRTHADSSGRLCPAPTPDSTPG 514

  Fly   497 VSSNSESSNHSPPSSPP 513
            :|...|:.....|...|
Human   515 LSQGGETCQQGCPGRNP 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	7/19 (37%)
		COG5048	<270..420	CDD:227381	72/175 (41%)
		zf-C2H2	271..293	CDD:278523	10/21 (48%)
		C2H2 Zn finger	273..293	CDD:275368	9/19 (47%)
		zf-H2C2_2	286..309	CDD:290200	12/22 (55%)
		C2H2 Zn finger	301..321	CDD:275368	8/19 (42%)
		zf-H2C2_2	313..338	CDD:290200	13/24 (54%)
		C2H2 Zn finger	329..349	CDD:275368	8/19 (42%)
		zf-H2C2_2	344..366	CDD:290200	12/21 (57%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		zf-H2C2_2	370..396	CDD:290200	15/51 (29%)
		C2H2 Zn finger	385..407	CDD:275368	7/47 (15%)
		zf-H2C2_2	400..424	CDD:290200	11/23 (48%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		zf-C2H2	441..463	CDD:278523	6/21 (29%)
		C2H2 Zn finger	443..463	CDD:275368	5/19 (26%)
ZNF835	NP_001005850.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	12..109		20/95 (21%)
		C2H2 Zn finger	112..132	CDD:275368	5/19 (26%)
		zf-H2C2_2	128..149	CDD:290200	7/35 (20%)
		COG5048	136..487	CDD:227381	110/360 (31%)
		C2H2 Zn finger	140..160	CDD:275368	4/26 (15%)
		zf-H2C2_2	152..177	CDD:290200	7/25 (28%)
		C2H2 Zn finger	168..188	CDD:275368	7/19 (37%)
		Ribosomal_L34e	178..>243	CDD:294621	9/66 (14%)
		C2H2 Zn finger	196..216	CDD:275368	2/19 (11%)
		C2H2 Zn finger	224..244	CDD:275368	2/21 (10%)
		zf-H2C2_2	236..259	CDD:290200	6/22 (27%)
		C2H2 Zn finger	252..272	CDD:275368	9/19 (47%)
		zf-H2C2_2	264..289	CDD:290200	13/24 (54%)
		C2H2 Zn finger	280..300	CDD:275368	8/19 (42%)
		zf-H2C2_2	292..317	CDD:290200	13/24 (54%)
		C2H2 Zn finger	308..328	CDD:275368	8/19 (42%)
		zf-H2C2_2	320..345	CDD:290200	13/24 (54%)
		C2H2 Zn finger	336..356	CDD:275368	8/19 (42%)
		zf-H2C2_2	348..373	CDD:290200	12/24 (50%)
		C2H2 Zn finger	364..384	CDD:275368	2/19 (11%)
		zf-H2C2_2	376..401	CDD:290200	3/24 (13%)
		C2H2 Zn finger	392..412	CDD:275368	5/19 (26%)
		zf-H2C2_2	404..429	CDD:290200	11/24 (46%)
		C2H2 Zn finger	420..440	CDD:275368	6/19 (32%)
		zf-H2C2_2	432..457	CDD:290200	9/24 (38%)
		C2H2 Zn finger	448..468	CDD:275368	5/19 (26%)
		zf-C2H2	474..496	CDD:278523	2/21 (10%)
		C2H2 Zn finger	476..496	CDD:275368	2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..537		11/35 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910