DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Kr-h1 and GFI1B

DIOPT Version :9

Sequence 1:NP_477466.1 Gene:Kr-h1 / 33861 FlyBaseID:FBgn0266450 Length:845 Species:Drosophila melanogaster
Sequence 2:NP_001358837.1 Gene:GFI1B / 8328 HGNCID:4238 Length:352 Species:Homo sapiens


Alignment Length:327 Identity:98/327 - (29%)
Similarity:143/327 - (43%) Gaps:63/327 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   141 QKQQQQQQHESITNAAPTAAPSAQRIKTEPV-GGFPASAAVVSQVRKPSASKPQFKCDQCGMTFG 204
            :::.:.:|.:::...||  ||....:.:.|. |..|.|.:       |...||.|..|....|:|
Human    61 KREPELEQDQNLARMAP--APEGPIVLSRPQDGDSPLSDS-------PPFYKPSFSWDTLATTYG 116

  Fly   205 SKSAHTSHTKSHSKNQDLSLNGASGAGVAAPVSTAAIELNDAGLPVGIPKSPTIKPLAN----VA 265
                       ||..|             ||.:..:..|..:....|.|..|:.:|..:    .:
Human   117 -----------HSYRQ-------------APSTMQSAFLEHSVSLYGSPLVPSTEPALDFSLRYS 157

  Fly   266 AGADPYQCNVCQKTFAVPARLIRHY-RTHTGERPFECEFCHKLFSVKENLQVHRRIHT------- 322
            .|.|.|.|..|.|.|:.|..|..|. |:|:|.|||.|:.|.|.|....:|:.|..:|:       
Human   158 PGMDAYHCVKCNKVFSTPHGLEVHVRRSHSGTRPFACDICGKTFGHAVSLEQHTHVHSQGIPAGS 222

  Fly   323 ---------------KERPYKCDVCGRAFEHSGKLHRHMRIHTGERPHKCSVCEKTFIQSGQLVI 372
                           :||.::|.:||:||:.|..|..|:.||:..||:.|..|.|.|.|...:..
Human   223 SPEPAPDPPGPHFLRQERSFECRMCGKAFKRSSTLSTHLLIHSDTRPYPCQFCGKRFHQKSDMKK 287

  Fly   373 HMRTHTGEKPYKCPEPGCGKGFTCSKQLKVHSRTHTGEKPYHCDICFRDFGYNHVLKLHRVQHYG 437
            |...||||||:||..  |||.|:.|..|..|||.|||.||:.|::|.:.|.....|:.||...:.
Human   288 HTYIHTGEKPHKCQV--CGKAFSQSSNLITHSRKHTGFKPFSCELCTKGFQRKVDLRRHRESQHN 350

  Fly   438 SK 439
            .|
Human   351 LK 352

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Kr-h1NP_477466.1 C2H2 Zn finger 196..216 CDD:275368 3/19 (16%)
COG5048 <270..420 CDD:227381 65/172 (38%)
zf-C2H2 271..293 CDD:278523 9/22 (41%)
C2H2 Zn finger 273..293 CDD:275368 8/20 (40%)
zf-H2C2_2 286..309 CDD:290200 11/23 (48%)
C2H2 Zn finger 301..321 CDD:275368 6/19 (32%)
zf-H2C2_2 313..338 CDD:290200 10/46 (22%)
C2H2 Zn finger 329..349 CDD:275368 8/19 (42%)
zf-H2C2_2 344..366 CDD:290200 9/21 (43%)
C2H2 Zn finger 357..377 CDD:275368 6/19 (32%)
zf-H2C2_2 370..396 CDD:290200 13/25 (52%)
C2H2 Zn finger 385..407 CDD:275368 10/21 (48%)
zf-H2C2_2 400..424 CDD:290200 12/23 (52%)
C2H2 Zn finger 415..435 CDD:275368 6/19 (32%)
zf-C2H2 441..463 CDD:278523
C2H2 Zn finger 443..463 CDD:275368
GFI1BNP_001358837.1 C2H2 Zn finger 165..186 CDD:275368 8/20 (40%)
C2H2 Zn finger 194..214 CDD:275368 6/19 (32%)
C2H2 Zn finger 244..264 CDD:275368 8/19 (42%)
COG5048 252..>329 CDD:227381 35/78 (45%)
C2H2 Zn finger 272..292 CDD:275368 6/19 (32%)
zf-H2C2_2 284..309 CDD:372612 13/26 (50%)
C2H2 Zn finger 300..320 CDD:275368 10/21 (48%)
C2H2 Zn finger 328..345 CDD:275368 4/16 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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