Protein Alignment Kr-h1 and ZNF208

DIOPT Version :10

• Sequence 1: NP_477466.1
• Gene: Kr-h1 / 33861
• FlyBaseID: FBgn0266450
• Length: 845
• Species: Drosophila melanogaster
• Sequence 2: NP_009084.2
• Gene: ZNF208 / 7757
• HGNCID: 12999
• Length: 1280
• Species: Homo sapiens
• Alignment Length: 334
• Identity: 119/334 - (35%)
• Similarity: 157/334 - (47%)
• Gaps: 28/334 - (8%)

  Fly   148 QHESI-TNAAPTAAPSAQRIKTEPVGGFPASAAVVSQVRKPSASKPQFKCDQCGMTFGSKSAHTS 211
            :||.| |...|        .|.|..|...:..:|.|:.:|..|.:..:||:.||..:.|.|..:.
Human   906 KHEVIHTGEKP--------YKCEECGKAFSWLSVFSKHKKTHAGEKFYKCEACGKAYKSSSTLSY 962

  Fly   212 HTKSHSKNQDLSLNGASGAGVAAPVSTAAIELNDAGLPVG------------IPKSPTIKPLANV 264
            |.|.|::.:..... ..|.|    .||.:|......:..|            ...|..:.....:
Human   963 HKKIHTEEKPYKYE-ECGKG----FSTFSILTKHKVIHTGEKPYKCEECGKAFNWSSNLMEHKKI 1022

  Fly   265 AAGADPYQCNVCQKTFAVPARLIRHYRTHTGERPFECEFCHKLFSVKENLQVHRRIHTKERPYKC 329
            ..|..||:|..|.|.|:.|:.|..|..||.||:|::||.|.|.||....|..|:..|..|.||||
Human  1023 HTGETPYKCEECDKAFSWPSSLTEHKATHAGEKPYKCEECGKAFSWPSRLTEHKATHAGEEPYKC 1087

  Fly   330 DVCGRAFEHSGKLHRHMRIHTGERPHKCSVCEKTFIQSGQLVIHMRTHTGEKPYKCPEPGCGKGF 394
            :.||:||..|..|..|.||||||:|:||..|.|:|.....|..|...|||||||||.|  |||.:
Human  1088 EECGKAFNWSSNLMEHKRIHTGEKPYKCEECGKSFSTFSILTKHKVIHTGEKPYKCEE--CGKAY 1150

  Fly   395 TCSKQLKVHSRTHTGEKPYHCDICFRDFGYNHVLKLHRVQHYGSKCYKCTICDETFKNKKEMEAH 459
            ..|..|..|.:.||.||||.|:.|.:.|....:|..|:|.|.|.|.|||..|.:.:|....:..|
Human  1151 KWSSTLSYHKKIHTVEKPYKCEECGKGFVMFSILAKHKVIHTGEKLYKCEECGKAYKWPSTLRYH 1215

  Fly   460 IKGHANEVP 468
            .|.|..|.|
Human  1216 KKIHTGEKP 1224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	7/19 (37%)
		COG5048	<270..420	CDD:227381	73/149 (49%)
		C2H2 Zn finger	273..293	CDD:275368	7/19 (37%)
		C2H2 Zn finger	301..321	CDD:275368	8/19 (42%)
		C2H2 Zn finger	329..349	CDD:275368	9/19 (47%)
		C2H2 Zn finger	357..377	CDD:275368	6/19 (32%)
		C2H2 Zn finger	385..407	CDD:275368	8/21 (38%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		zf-C2H2	441..463	CDD:395048	7/21 (33%)
		C2H2 Zn finger	443..463	CDD:275368	5/19 (26%)
ZNF208	NP_009084.2	KRAB	4..64	CDD:214630
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368
		COG5048	227..619	CDD:227381
		C2H2 Zn finger	231..251	CDD:275368
		C2H2 Zn finger	259..279	CDD:275368
		C2H2 Zn finger	287..307	CDD:275368
		C2H2 Zn finger	315..335	CDD:275368
		C2H2 Zn finger	343..363	CDD:275368
		C2H2 Zn finger	371..391	CDD:275368
		C2H2 Zn finger	399..419	CDD:275368
		C2H2 Zn finger	427..447	CDD:275368
		C2H2 Zn finger	455..475	CDD:275368
		C2H2 Zn finger	499..519	CDD:275368
		C2H2 Zn finger	527..547	CDD:275368
		C2H2 Zn finger	555..575	CDD:275368
		C2H2 Zn finger	583..603	CDD:275368
		C2H2 Zn finger	611..631	CDD:275368
		C2H2 Zn finger	639..659	CDD:275368
		C2H2 Zn finger	667..687	CDD:275368
		COG5048	691..1133	CDD:227381	78/239 (33%)
		C2H2 Zn finger	695..715	CDD:275368
		C2H2 Zn finger	723..743	CDD:275368
		C2H2 Zn finger	751..771	CDD:275368
		C2H2 Zn finger	779..799	CDD:275368
		C2H2 Zn finger	807..827	CDD:275368
		C2H2 Zn finger	835..855	CDD:275368
		C2H2 Zn finger	863..883	CDD:275368
		C2H2 Zn finger	891..911	CDD:275368	2/4 (50%)
		C2H2 Zn finger	919..939	CDD:275368	5/19 (26%)
		C2H2 Zn finger	947..967	CDD:275368	7/19 (37%)
		C2H2 Zn finger	976..995	CDD:275368	5/23 (22%)
		C2H2 Zn finger	1003..1023	CDD:275368	1/19 (5%)
		C2H2 Zn finger	1031..1051	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1059..1079	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1087..1107	CDD:275368	9/19 (47%)
		C2H2 Zn finger	1115..1135	CDD:275368	6/19 (32%)
		SFP1	<1137..1217	CDD:227516	35/81 (43%)
		C2H2 Zn finger	1143..1163	CDD:275368	8/21 (38%)
		C2H2 Zn finger	1171..1191	CDD:275368	6/19 (32%)
		SFP1	<1193..1273	CDD:227516	12/32 (38%)
		C2H2 Zn finger	1199..1219	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1227..1247	CDD:275368
		C2H2 Zn finger	1255..1275	CDD:275368