Protein Alignment Kr-h1 and ZNF143

DIOPT Version :10

• Sequence 1: NP_477466.1
• Gene: Kr-h1 / 33861
• FlyBaseID: FBgn0266450
• Length: 845
• Species: Drosophila melanogaster
• Sequence 2: XP_005253178.1
• Gene: ZNF143 / 7702
• HGNCID: 12928
• Length: 653
• Species: Homo sapiens
• Alignment Length: 703
• Identity: 172/703 - (24%)
• Similarity: 248/703 - (35%)
• Gaps: 182/703 - (25%)

  Fly    58 YSANQLLIKTEQSSQAQFCLQVPPPLTATTTSVGLGVPPSGGQQ-EHFELLQTPQQRQMQLQLQD 121
            :|...||.:..:.||                  |:...|.||.: :|..|..|.     .:.:.|
Human    12 FSEKMLLAQINRDSQ------------------GMTEFPGGGMEAQHVTLCLTE-----AVTVAD 53

  Fly   122 QHQQEQQQFVSYQLAIQQHQKQQQQQQHESITNAAPTAAPSAQRIKTEPVGGFPASAAVVSQVRK 186
            ....|..:.||.| |:..........||    |:........|.|:.|     ..|||.|..|..
Human    54 GDNLENMEGVSLQ-AVTLADGSTAYIQH----NSKDAKLIDGQVIQLE-----DGSAAYVQHVPI 108

  Fly   187 PSASKPQFKCD--QCGMTFGSKSAHTSHTKSHSKNQD----LSLNGASGA----GVAAPVSTAAI 241
            |.::....:.:  |........:|...||...|.:|.    :.|...:.|    .|..|.|...:
Human   109 PKSTGDSLRLEDGQAVQLEDGTTAFIHHTSKDSYDQSALQAVQLEDGTTAYIHHAVQVPQSDTIL 173

  Fly   242 ELNDAGLPVGIPKS------PTIKPLANVAA---------------------------------- 266
            .:...|...|:...      .||..|...||
Human   174 AIQADGTVAGLHTGDATIDPDTISALEQYAAKVSIDGSESVAGTGMIGENEQEKKMQIVLQGHAT 238

  Fly   267 ---------GADPYQCNV--CQKTFAVPARLIRHYRTHTGERPFECEF--CHKLFSVKENLQVHR 318
                     |...::|..  |.|.:.....|..|.|:|||:||::||.  |.|.|:....|:.|.
Human   239 RVTAKSQQSGEKAFRCEYDGCGKLYTTAHHLKVHERSHTGDRPYQCEHAGCGKAFATGYGLKSHV 303

  Fly   319 RIHTKERPYKC--DVCGRAFEHSGKLHRHMRIHTGERPHKCSV--CEKTFIQSGQLVIHMRTHTG 379
            |.||.|:||:|  |.|.::|:.||.|.:|:|.||||||.||..  |.::|..|....:|:|||||
Human   304 RTHTGEKPYRCSEDNCTKSFKTSGDLQKHIRTHTGERPFKCPFEGCGRSFTTSNIRKVHVRTHTG 368

  Fly   380 EKPYKCPEPGCGKGFTCSKQLKVHSRTHTGEKPYHCDI--CFRDFGYNHVLKLHRVQHYGSKCYK 442
            |:||.|.|||||:.|..:...|.|.|.|||||||.|.:  |.:.|.....|..|.|.|..||.|.
Human   369 ERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVVHTHSKPYN 433

  Fly   443 CTICDETFKNKKEMEAHIK-GHANEVPDDEAEAA------------------------------A 476
            |..|.:|:|....:..|.: .|.:..|.:|.:.|                              :
Human   434 CNHCGKTYKQISTLAMHKRTAHNDTEPIEEEQEAFFEPPPGQGEDVLKGSQITYVTGVEGDDVVS 498

  Fly   477 ASAAASTSAGSSAGSPSLQGVSSNSESSNHSPPSSPPATKKPRQARQPRVSKTVAATL--SIPTS 539
            ...|..|.:|.|      |.|:..|:........|        ||....:..|:....  ..|.:
Human   499 TQVATVTQSGLS------QQVTLISQDGTQHVNIS--------QADMQAIGNTITMVTQDGTPIT 549

  Fly   540 SPLSPSSLSSTYSPSASSMASPPPTSAHYLPVQMEADALSRDSGVSSAQPAHSTY---ADEEPTD 601
            .|...:.:||..:.|. :|.:...|....:.:..:..|....:........||.:   .:..|..
Human   550 VPAHDAVISSAGTHSV-AMVTAEGTEGEQVAIVAQDLAAFHTASSEMGHQQHSHHLVTTETRPLT 613

  Fly   602 L----SMQQVQGQLPESTVDYYQAPPSLLELQPQPAGLTINPALLEAASIARR 650
            |    :..|:..||.|                        .|:|.||..||.|
Human   614 LVATSNGTQIAVQLGE------------------------QPSLEEAIRIASR 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	4/21 (19%)
		COG5048	<270..420	CDD:227381	72/159 (45%)
		C2H2 Zn finger	273..293	CDD:275368	6/21 (29%)
		C2H2 Zn finger	301..321	CDD:275368	8/21 (38%)
		C2H2 Zn finger	329..349	CDD:275368	9/21 (43%)
		C2H2 Zn finger	357..377	CDD:275368	6/21 (29%)
		C2H2 Zn finger	385..407	CDD:275368	10/21 (48%)
		C2H2 Zn finger	415..435	CDD:275368	6/21 (29%)
		zf-C2H2	441..463	CDD:395048	6/22 (27%)
		C2H2 Zn finger	443..463	CDD:275368	5/20 (25%)
ZNF143	XP_005253178.1	C2H2 Zn finger	254..276	CDD:275368	6/21 (29%)
		COG5048	<266..439	CDD:227381	79/172 (46%)
		C2H2 Zn finger	284..306	CDD:275368	8/21 (38%)
		C2H2 Zn finger	314..336	CDD:275368	9/21 (43%)
		C2H2 Zn finger	344..366	CDD:275368	6/21 (29%)
		C2H2 Zn finger	374..396	CDD:275368	10/21 (48%)
		C2H2 Zn finger	404..426	CDD:275368	6/21 (29%)
		C2H2 Zn finger	434..453	CDD:275368	5/18 (28%)