DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kr-h1 and ZNF132

DIOPT Version :9

Sequence 1:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_003424.3	Gene:	ZNF132 / 7691	HGNCID:	12916	Length:	706	Species:	Homo sapiens

Alignment Length:	362	Identity:	120/362 - (33%)
Similarity:	176/362 - (48%)	Gaps:	33/362 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 SYQLAIQQHQKQQQQQQHESITNAAPTAAPSAQRIKTEPVGGFPASAAVVSQVRKPSASKPQFKC 196
            |:...:::|||...:.::........|               |......|...|..|..:| ::|
Human   301 SHSSKLRKHQKFHTEVKYYECIACGKT---------------FNHKLTFVHHQRIHSGERP-YEC 349

  Fly   197 DQCGMTFGSKSAHTSHTKSHSKNQDL-----------SLNGASGAGVAAPVSTAAIELNDAGLPV 250
            |:||..|.::|....|.|.|:..:..           |.|......|...|  ...|.:..|  .
Human   350 DECGKAFSNRSHLIRHEKVHTGERPFECLKCGRAFSQSSNFLRHQKVHTQV--RPYECSQCG--K 410

  Fly   251 GIPKSPTIKPLANVAAGADPYQCNVCQKTFAVPARLIRHYRTHTGERPFECEFCHKLFSVKENLQ 315
            ...:|..:.....|..|..||:|:.|.:.|...:.|.:|.:.|||||||||..|.:.||...:|.
Human   411 SFSRSSALIQHWRVHTGERPYECSECGRAFNNNSNLAQHQKVHTGERPFECSECGRDFSQSSHLL 475

  Fly   316 VHRRIHTKERPYKCDVCGRAFEHSGKLHRHMRIHTGERPHKCSVCEKTFIQSGQLVIHMRTHTGE 380
            .|:::||.|||::|..||:||.:|..|.:|.::|||:||::||.|.|:|.:|..|:.|.|.||||
Human   476 RHQKVHTGERPFECCDCGKAFSNSSTLIQHQKVHTGQRPYECSECRKSFSRSSSLIQHWRIHTGE 540

  Fly   381 KPYKCPEPGCGKGFTCSKQLKVHSRTHTGEKPYHCDICFRDFGYNHVLKLHRVQHYGSKCYKCTI 445
            |||:|.|  |||.|..|..|..|.|.||.|:||.|:.|.:.|..|.:|..|:..|.|.|.|||:.
Human   541 KPYECSE--CGKAFAHSSTLIEHWRVHTKERPYECNECGKFFSQNSILIKHQKVHTGEKPYKCSE 603

  Fly   446 CDETFKNKKEMEAHIKGHANEVPDDEAEAAAASAAAS 482
            |.:.|..|..:..|.:.|..|.|.:.:|...|.::.|
Human   604 CGKFFSRKSSLICHWRVHTGERPYECSECGRAFSSNS 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	8/19 (42%)
		COG5048	<270..420	CDD:227381	72/149 (48%)
		zf-C2H2	271..293	CDD:278523	6/21 (29%)
		C2H2 Zn finger	273..293	CDD:275368	5/19 (26%)
		zf-H2C2_2	286..309	CDD:290200	12/22 (55%)
		C2H2 Zn finger	301..321	CDD:275368	6/19 (32%)
		zf-H2C2_2	313..338	CDD:290200	12/24 (50%)
		C2H2 Zn finger	329..349	CDD:275368	8/19 (42%)
		zf-H2C2_2	344..366	CDD:290200	11/21 (52%)
		C2H2 Zn finger	357..377	CDD:275368	9/19 (47%)
		zf-H2C2_2	370..396	CDD:290200	16/25 (64%)
		C2H2 Zn finger	385..407	CDD:275368	10/21 (48%)
		zf-H2C2_2	400..424	CDD:290200	11/23 (48%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		zf-C2H2	441..463	CDD:278523	7/21 (33%)
		C2H2 Zn finger	443..463	CDD:275368	5/19 (26%)
ZNF132	NP_003424.3	KRAB	37..78	CDD:307490
		COG5048	105..528	CDD:227381	72/246 (29%)
		C2H2 Zn finger	116..136	CDD:275368
		C2H2 Zn finger	144..164	CDD:275368
		C2H2 Zn finger	238..285	CDD:275368
		C2H2 Zn finger	293..313	CDD:275368	4/11 (36%)
		C2H2 Zn finger	321..341	CDD:275368	4/34 (12%)
		C2H2 Zn finger	349..369	CDD:275368	8/19 (42%)
		C2H2 Zn finger	377..397	CDD:275368	2/19 (11%)
		COG5048	383..>706	CDD:227381	101/264 (38%)
		C2H2 Zn finger	405..425	CDD:275368	2/21 (10%)
		C2H2 Zn finger	433..453	CDD:275368	5/19 (26%)
		C2H2 Zn finger	461..481	CDD:275368	6/19 (32%)
		C2H2 Zn finger	489..509	CDD:275368	8/19 (42%)
		C2H2 Zn finger	517..537	CDD:275368	9/19 (47%)
		C2H2 Zn finger	545..565	CDD:275368	10/21 (48%)
		C2H2 Zn finger	573..593	CDD:275368	6/19 (32%)
		C2H2 Zn finger	601..621	CDD:275368	5/19 (26%)
		C2H2 Zn finger	629..649	CDD:275368	3/12 (25%)
		C2H2 Zn finger	657..677	CDD:275368
		C2H2 Zn finger	685..705	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910