DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kr-h1 and Zbtb49

DIOPT Version :9

Sequence 1:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_083438.1	Gene:	Zbtb49 / 75079	MGIID:	1922329	Length:	756	Species:	Mus musculus

Alignment Length:	651	Identity:	179/651 - (27%)
Similarity:	252/651 - (38%)	Gaps:	141/651 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 KSPAKDSATTKMVYYSANQLLIKTEQSSQAQFCLQVPPPLTATTTSVGLGVP-------PSGG-- 99
            :|.|.|.......:|....|.....:..||    :||..:.|...|.....|       .:||
Mouse   137 QSVALDGTCAVSEHYPPPSLQECPVEGPQA----KVPAEVNARAPSANFSRPTEVSKPDAAGGSC 197

  Fly   100 ------QQEHFELLQTPQQRQMQLQLQ-----DQHQQEQQQFVSYQLAIQQHQKQQQQQ------ 147
                  |..|:..|:|...:|...|..     ...||...:..|..||....|...:.:
Mouse   198 PELPCKQPNHYYKLRTLYSKQYYKQTACPSQVPATQQPLTRSASTDLAAADSQPPVEGRPAVLET 262

  Fly   148 -QHESITNAAPTAAPSAQRIKTEPVGGFPASAAVVSQVRKPSA---SKPQFKCDQCGMTFGSKSA 208
             :|...|..||....|....:.:|:...||     .|:|...|   .|..|...|       :||
Mouse   263 PEHLPSTFVAPPVRNSGNDSEADPLSEPPA-----KQMRLKKAMHLKKLNFLKSQ-------QSA 315

  Fly   209 H-TSH----------TKSHSKNQDLSLNGA-----SGAGVAAPVSTAAIELNDAGLPVGIPKSPT 257
            . |||          .:|.:|...:...|:     .|.|...|.|:...||         |.:|
Mouse   316 ECTSHPEPDNGLARREESAAKEDAVERAGSQTAEEKGRGELGPESSREEEL---------PGAP- 370

  Fly   258 IKPLANVAAGADP---------YQCNVCQKTFAVPARLIRHYRTHTGERPFECEFCHKLFSVKEN 313
                   |:..||         |.|.:|.|.|..|:.|..|.|:||||:||||..|.|.||...|
Mouse   371 -------ASWEDPSQALQPQKQYACELCGKPFKHPSNLELHKRSHTGEKPFECNICGKHFSQAGN 428

  Fly   314 LQVHRRIHTKERPYKCDVCGRAFEHSGKLHRHMRIHTGERPHKCSVCEKTFIQSGQLVIHMRTHT 378
            ||.|.|.|:.|:||.|::||:.|..||.:.||:.||:||:||.|..|.:.|.....|..|.:|||
Mouse   429 LQTHLRRHSGEKPYICEICGKRFAASGDVQRHIIIHSGEKPHLCDTCGRGFSNFSNLKEHKKTHT 493

  Fly   379 GEKPYKCPEPGCGKGFTCSKQLKVHSRTHTGEKPYHCDICFRDFGYNHVLKLHRVQHYGSKCYKC 443
            .:|.:.|.|  |||.|...::|..|...||||:||.|..|.:.||.:..|:.|...|.|.|.|.|
Mouse   494 ADKVFTCDE--CGKSFNMQRKLVKHRVRHTGERPYSCPACGKCFGGSGDLRRHVRTHTGEKPYSC 556

  Fly   444 TICDETFKNKKEMEAHIKGHANEVPDDEAEAAAASAAASTSAGSSAGSPSLQGVSSNSESSNHSP 508
            .:|.:.|.....:..|.:.|..                     :.|.||.:.|     |.|....
Mouse   557 EVCSKCFTRSAVLRRHKRMHGR---------------------ADARSPVVLG-----ELSRPIE 595

  Fly   509 PSSPPATKKPRQARQPRVSKTVAATLSIPTS--SPLSP--SSL-------SSTYSPSASSMASPP 562
            ||.     ..|.......|:.|:.|| :|.|  .|:.|  ||:       |.:|....|.:.  |
Mouse   596 PSD-----LDRSQSSDSFSQDVSVTL-MPVSVKLPVQPVESSVAGFDGHCSGSYCKLRSMLR--P 652

  Fly   563 PTSAHYLPVQMEADALSRDSGVSSAQPAHSTYADEEPT-DLSMQQVQGQLPE----STVDYYQAP 622
            |..:....:.:|...|::...:.| ||....|:|.||: .:...|..|....    :|:|.:...
Mouse   653 PGMSDQDRLSLEPSKLAKPPELQS-QPQAYAYSDVEPSAGVEQPQADGMAVSRSSLATLDNHCTE 716

  Fly   623 P 623
            |
Mouse   717 P 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	6/30 (20%)
		COG5048	<270..420	CDD:227381	70/158 (44%)
		zf-C2H2	271..293	CDD:278523	9/21 (43%)
		C2H2 Zn finger	273..293	CDD:275368	8/19 (42%)
		zf-H2C2_2	286..309	CDD:290200	13/22 (59%)
		C2H2 Zn finger	301..321	CDD:275368	10/19 (53%)
		zf-H2C2_2	313..338	CDD:290200	13/24 (54%)
		C2H2 Zn finger	329..349	CDD:275368	8/19 (42%)
		zf-H2C2_2	344..366	CDD:290200	11/21 (52%)
		C2H2 Zn finger	357..377	CDD:275368	5/19 (26%)
		zf-H2C2_2	370..396	CDD:290200	12/25 (48%)
		C2H2 Zn finger	385..407	CDD:275368	8/21 (38%)
		zf-H2C2_2	400..424	CDD:290200	11/23 (48%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		zf-C2H2	441..463	CDD:278523	5/21 (24%)
		C2H2 Zn finger	443..463	CDD:275368	4/19 (21%)
Zbtb49	NP_083438.1	BTB	15..118	CDD:279045
		BTB	26..119	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..197		4/20 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..290		12/63 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..379		20/91 (22%)
		COG5048	<376..576	CDD:227381	82/201 (41%)
		zf-C2H2	386..408	CDD:278523	9/21 (43%)
		C2H2 Zn finger	388..408	CDD:275368	8/19 (42%)
		zf-H2C2_2	400..425	CDD:290200	14/24 (58%)
		C2H2 Zn finger	416..436	CDD:275368	10/19 (53%)
		zf-H2C2_2	428..452	CDD:290200	12/23 (52%)
		C2H2 Zn finger	444..464	CDD:275368	8/19 (42%)
		zf-H2C2_2	456..481	CDD:290200	11/24 (46%)
		C2H2 Zn finger	472..492	CDD:275368	5/19 (26%)
		zf-H2C2_2	484..508	CDD:290200	11/25 (44%)
		C2H2 Zn finger	500..520	CDD:275368	8/21 (38%)
		zf-H2C2_2	513..535	CDD:290200	10/21 (48%)
		C2H2 Zn finger	528..548	CDD:275368	6/19 (32%)
		zf-H2C2_2	540..565	CDD:290200	9/24 (38%)
		C2H2 Zn finger	556..576	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000