DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kr-h1 and gzf1

DIOPT Version :9

Sequence 1:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_001039101.1	Gene:	gzf1 / 733920	XenbaseID:	XB-GENE-1020991	Length:	697	Species:	Xenopus tropicalis

Alignment Length:	464	Identity:	127/464 - (27%)
Similarity:	198/464 - (42%)	Gaps:	74/464 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 KAVAVKKSPAKDSATTKMVYYSANQLLIK------TEQSSQAQFCLQVPPPLTATTTSVGLGVPP 96
            |..|:||..||...:|..|  |..:.:::      |.:..:.|...|..|   ....:.|:.||.
Frog   209 KKEALKKPQAKPKRSTGRV--SGKKAVVEIPKKKYTRKLREQQNIAQTRP---IENGNDGVQVPS 268

  Fly    97 SGGQQEHFELLQT-PQQRQMQLQLQDQHQQEQQQFVSYQLAIQQHQKQQQQQQHESITNAAPTAA 160
            :         :|| .:|.:..::.:|....|..:  ||:...|.:..|
Frog   269 N---------MQTADEQSEDSVKAEDDSHCEDSE--SYKNGDQDNNDQ----------------- 305

  Fly   161 PSAQRIKTEPVGG--FPASAAVVSQVRKPSA-SKPQFKCDQCGMTFGSK---SAHTSHTKSHSKN 219
             ||..:.. ||.|  |....:.:...::... |:..|:||.|..||.::   .:|..|..|:.:.
Frog   306 -SANMVSC-PVCGKSFADEKSFLKHSKQEHLDSEIVFRCDICSQTFANRCNLKSHQRHVHSNERR 368

  Fly   220 QDLSLNGASGAGVAAPVSTAAIELNDAG--------LPVGIPKSPTIKPLANVAAGADPYQCNVC 276
            ....|.|..... ...:....|::::.|        ...|:....::........|..|:.|..|
Frog   369 FPCELCGKKFKR-KKDIKRHIIQVHEGGRERHFCKLCGKGLSSKTSLSLHERTHTGDKPFSCPHC 432

  Fly   277 QKTFAVPARLIRHYRTHTGERPFECEFCHKLFSVKENLQVHRRIHTKERPYKCDVCGRAFEHSGK 341
            |..|:..:.|..|.||||||:||.|:.|...|:....|..|:|.||.|:|:.|:.||::|.....
Frog   433 QAKFSQTSALKTHLRTHTGEKPFVCDECDARFTQNHMLIYHKRCHTGEKPFMCETCGKSFASKEY 497

  Fly   342 LHRHMRIHTGERPHKCSVCEKTFIQSGQLVIHMRTHTGEKPYKCPEPGCGKGFTCSKQLKVHSRT 406
            |..|.|||||.:|.||..|.:||.|...|..|::.||||:||.|.:  |||.||....|:.|.|.
Frog   498 LKHHNRIHTGSKPFKCDFCCRTFAQRNSLYQHIKVHTGERPYCCDQ--CGKQFTQLNALQRHHRI 560

  Fly   407 HTGEKPYHCDICFRDFGYNHVLKLHRVQHYGSKCYKCTIC-------DETFKNKKEMEAHIKGHA 464
            ||||||:.|..|.|.|.....|:.|...|..:..:|..:.       ||..|:::..|
Frog   561 HTGEKPFMCSACQRTFTDQSTLRRHTSIHDKNTPWKSFLVVLDPASKDEGQKSEEGRE------- 618

  Fly   465 NEVPDDEAE 473
             ::|:..|:
Frog   619 -DLPNPGAD 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	7/22 (32%)
		COG5048	<270..420	CDD:227381	68/149 (46%)
		zf-C2H2	271..293	CDD:278523	7/21 (33%)
		C2H2 Zn finger	273..293	CDD:275368	7/19 (37%)
		zf-H2C2_2	286..309	CDD:290200	12/22 (55%)
		C2H2 Zn finger	301..321	CDD:275368	6/19 (32%)
		zf-H2C2_2	313..338	CDD:290200	11/24 (46%)
		C2H2 Zn finger	329..349	CDD:275368	7/19 (37%)
		zf-H2C2_2	344..366	CDD:290200	12/21 (57%)
		C2H2 Zn finger	357..377	CDD:275368	7/19 (37%)
		zf-H2C2_2	370..396	CDD:290200	13/25 (52%)
		C2H2 Zn finger	385..407	CDD:275368	9/21 (43%)
		zf-H2C2_2	400..424	CDD:290200	13/23 (57%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		zf-C2H2	441..463	CDD:278523	5/28 (18%)
		C2H2 Zn finger	443..463	CDD:275368	4/26 (15%)
gzf1	NP_001039101.1	BTB	21..125	CDD:279045
		BTB	32..133	CDD:197585
		C2H2 Zn finger	312..333	CDD:275368	4/21 (19%)
		C2H2 Zn finger	342..363	CDD:275368	7/20 (35%)
		C2H2 Zn finger	401..421	CDD:275368	1/19 (5%)
		zf-H2C2_2	413..438	CDD:290200	6/24 (25%)
		zf-C2H2_8	426..532	CDD:292531	45/105 (43%)
		C2H2 Zn finger	429..449	CDD:275368	7/19 (37%)
		zf-H2C2_2	441..466	CDD:290200	13/24 (54%)
		C2H2 Zn finger	457..477	CDD:275368	6/19 (32%)
		zf-H2C2_2	469..494	CDD:290200	11/24 (46%)
		C2H2 Zn finger	485..505	CDD:275368	7/19 (37%)
		zf-H2C2_2	497..522	CDD:290200	13/24 (54%)
		C2H2 Zn finger	513..533	CDD:275368	7/19 (37%)
		zf-H2C2_2	525..550	CDD:290200	13/26 (50%)
		COG5048	537..>594	CDD:227381	24/58 (41%)
		C2H2 Zn finger	541..561	CDD:275368	9/21 (43%)
		zf-H2C2_2	553..577	CDD:290200	12/23 (52%)
		C2H2 Zn finger	569..589	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910