DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kr-h1 and znf76

DIOPT Version :9

Sequence 1:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	XP_009294034.1	Gene:	znf76 / 564210	ZFINID:	ZDB-GENE-061027-379	Length:	534	Species:	Danio rerio

Alignment Length:	529	Identity:	143/529 - (27%)
Similarity:	214/529 - (40%)	Gaps:	100/529 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 QHESITNAAPTAAPSAQRIKTE----------PVGGFPASAAVVSQVRKPSAS----KPQFKCDQ 198
            ||.|:......|....|.::.|          |..||...|....|:...|.:    :|....:.
Zfish    63 QHVSVQQKESLAFEDGQAVQLEDGTTAFIHHTPKEGFDPGAVEAVQLEDGSTAYIHHQPGGAVEM 127

  Fly   199 CGMTFGSKSAHTSHTKSHSKNQDLSLNGASGAGVAAPVSTAAIELNDAGLPVGIPKSPTIKPLAN 263
            ...|..:...:.|.........|.::..|:||      ...:|:|...|   .:..|..::.:.:
Zfish   128 SADTIATLENYASKLTGSEVEADDNMENANGA------EQTSIQLMFEG---KVWSSSKVQQVTD 183

  Fly   264 VAAGADPYQCN--VCQKTFAVPARLIRHYRTHTGERPFECEF--CHKLFSVKENLQVHRRIHTKE 324
            .:     ::|.  .|.:.:.....|..|.|:|||:||:.||.  |.|.|:....|:.|:|.||.|
Zfish   184 RS-----FRCEHPGCGRYYTTAHHLKVHERSHTGDRPYRCEVHSCGKAFATGYGLKSHQRTHTGE 243

  Fly   325 RPYKC--DVCGRAFEHSGKLHRHMRIHTGERPHKCSV--CEKTFIQSGQLVIHMRTHTGEKPYKC 385
            :||||  |:|.:||:.||.|.:|:|.||||:|.||..  |.::|..|....:|.||||||:||.|
Zfish   244 KPYKCPEDMCYKAFKTSGDLQKHVRTHTGEKPFKCPFEGCGRSFTTSNIRKVHTRTHTGERPYLC 308

  Fly   386 PEPGCGKGFTCSKQLKVHSRTHTGEKPYHCDI--CFRDFGYNHVLKLHRVQHYGSKCYKCTICDE 448
            |||.||:.|..:...|.|.|.|||||||.|.:  |.:.|.....|..|.|.|...|.|.|:.|.:
Zfish   309 PEPSCGRAFASATNYKNHMRIHTGEKPYLCTVPGCGKSFTEYSSLYKHHVVHTHCKPYTCSHCGK 373

  Fly   449 TFKNKKEMEAHIK-GHAN-EVPDDEAEAAAASAAASTSAGSSAGSPSLQGVSSNSESSNHSPPSS 511
            |::....:..|.: .|.: :..:|:||..             .|||         :...||.|.:
Zfish   374 TYRQTSTLAMHKRTAHGDFDTTEDDAEVL-------------DGSP---------QDVGHSEPDA 416

  Fly   512 PPATKKPRQARQPRVSKTVAATLSIPTSSPLSPSSLSSTYSPSASSMASPPPTSAHY--LPVQME 574
                             .:|...:...||.|.....:.|......|..|.|...:|.  ..|.|.
Zfish   417 -----------------DIAMETNDIISSHLQVLGTAVTMVTQDGSTISVPAQQSHSGGQQVTML 464

  Fly   575 AD-------ALSRDSGV-----SSAQPAHSTYADEEPTDLSMQQVQGQLPESTVDYYQAPPSLLE 627
            .|       |:....|:     |||....:..|.|..|.:::|....|..|..:       ::..
Zfish   465 TDGKELQPVAIVTSDGIMTEVNSSAYQQVALLATENGTQIAVQLEDQQTLEEAI-------TMAT 522

  Fly   628 LQPQPAGLT 636
            ...|.:|||
Zfish   523 AAIQHSGLT 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	2/19 (11%)
		COG5048	<270..420	CDD:227381	72/159 (45%)
		zf-C2H2	271..293	CDD:278523	5/23 (22%)
		C2H2 Zn finger	273..293	CDD:275368	5/21 (24%)
		zf-H2C2_2	286..309	CDD:290200	12/24 (50%)
		C2H2 Zn finger	301..321	CDD:275368	8/21 (38%)
		zf-H2C2_2	313..338	CDD:290200	14/26 (54%)
		C2H2 Zn finger	329..349	CDD:275368	10/21 (48%)
		zf-H2C2_2	344..366	CDD:290200	11/23 (48%)
		C2H2 Zn finger	357..377	CDD:275368	6/21 (29%)
		zf-H2C2_2	370..396	CDD:290200	16/25 (64%)
		C2H2 Zn finger	385..407	CDD:275368	10/21 (48%)
		zf-H2C2_2	400..424	CDD:290200	13/25 (52%)
		C2H2 Zn finger	415..435	CDD:275368	6/21 (29%)
		zf-C2H2	441..463	CDD:278523	5/22 (23%)
		C2H2 Zn finger	443..463	CDD:275368	4/20 (20%)
znf76	XP_009294034.1	C2H2 Zn finger	188..210	CDD:275368	5/21 (24%)
		zf-H2C2_2	202..229	CDD:290200	13/26 (50%)
		C2H2 Zn finger	218..240	CDD:275368	8/21 (38%)
		zf-H2C2_2	233..259	CDD:290200	14/25 (56%)
		zf-C2H2_aberr	246..367	CDD:293622	56/120 (47%)
		C2H2 Zn finger	248..270	CDD:275368	10/21 (48%)
		zf-H2C2_2	262..289	CDD:290200	12/26 (46%)
		C2H2 Zn finger	278..300	CDD:275368	6/21 (29%)
		zf-H2C2_2	294..319	CDD:290200	16/24 (67%)
		C2H2 Zn finger	308..330	CDD:275368	10/21 (48%)
		zf-H2C2_2	322..348	CDD:290200	12/25 (48%)
		C2H2 Zn finger	338..360	CDD:275368	6/21 (29%)
		C2H2 Zn finger	368..387	CDD:275368	4/18 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910