DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kr-h1 and Zfp316

DIOPT Version :9

Sequence 1:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_001100591.1	Gene:	Zfp316 / 304293	RGDID:	1311647	Length:	1016	Species:	Rattus norvegicus

Alignment Length:	427	Identity:	128/427 - (29%)
Similarity:	166/427 - (38%)	Gaps:	100/427 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 NAAPTA-APSAQRIKTEPVGGF---PASAAVVSQVRKPSASKPQFKCDQCGMTFGSKSAHTSHTK 214
            :|.|.| |.|..|.....||..   ||.||:..:       :..:.|..||.|||.::|...|.:
  Rat   668 SAGPGARADSGLRAFAPAVGSLLSEPAPAALAEE-------ESPWICSDCGKTFGRRAALAKHQR 725

  Fly   215 SHSKNQDLSLNGASGAGVAAPVSTAAIELNDAGLPVGIPKSPTIKPLANVAAGADPYQCNVCQKT 279
            .|                                                 ||..|::|..|.|:
  Rat   726 YH-------------------------------------------------AGERPHRCADCGKS 741

  Fly   280 FAVPARLIRHYRTHTGERPFECEFCHKLFSVKENLQVHRRIHTKERPYKCDVCGRAFEHSGKLHR 344
            |...:.|.||.|||||||||.|..|...|:...:|..|.|.||.|:|:.|.|||..|.....|..
  Rat   742 FVYGSHLARHRRTHTGERPFPCPECGARFARGSHLAAHVRGHTGEKPFVCGVCGAGFSRRAHLTA 806

  Fly   345 HMRIHTGERPHKCSVCEKTFIQSGQLVIHMRTHTGEKPYKCPEPGCGKGFTCSKQLKVHSRTHTG 409
            |.|.||||||:.|:.|.:.|.||..|..|...|..|||::||:  |||||..|...|.|.|||||
  Rat   807 HGRAHTGERPYACAECGRRFGQSAALTRHQWAHAEEKPHRCPD--CGKGFGHSSDFKRHRRTHTG 869

  Fly   410 EKPYHCDICFRDFGYNHVLKLHRVQHYGSKCYKCTICDETFKNKKEMEAHIKGHANEVPDDEAEA 474
            |||:.|..|.|.|.....|..||..|.|.:.:.|..|.:.|..:..:..|.:.|..|.|
  Rat   870 EKPFRCADCGRGFAQRSNLAKHRRGHTGERPFPCPECGKRFSQRSVLVTHQRTHTGERP------ 928

  Fly   475 AAASAAASTSAGSSAGSPSLQGVSSNSESSNHSPPSSPPATKKPRQARQPRVSKTVAATLSIPTS 539
                     ...|:.|....|.....:....|......||.....:|:.|        ..:||
  Rat   929 ---------YLCSNCGRRFSQSSHLLTHMKTHRGQGGAPAQNTSAKAQAP--------AKAIP-- 974

  Fly   540 SPLSPSSLSS------------TYSPSASSMASPPPT 564
             ||.||...|            ::....::.|||..|
  Rat   975 -PLPPSGSGSGAGTLLEFAGGTSFGSDPAAFASPSGT 1010

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	8/19 (42%)
		COG5048	<270..420	CDD:227381	72/149 (48%)
		zf-C2H2	271..293	CDD:278523	8/21 (38%)
		C2H2 Zn finger	273..293	CDD:275368	8/19 (42%)
		zf-H2C2_2	286..309	CDD:290200	14/22 (64%)
		C2H2 Zn finger	301..321	CDD:275368	6/19 (32%)
		zf-H2C2_2	313..338	CDD:290200	12/24 (50%)
		C2H2 Zn finger	329..349	CDD:275368	8/19 (42%)
		zf-H2C2_2	344..366	CDD:290200	11/21 (52%)
		C2H2 Zn finger	357..377	CDD:275368	7/19 (37%)
		zf-H2C2_2	370..396	CDD:290200	13/25 (52%)
		C2H2 Zn finger	385..407	CDD:275368	11/21 (52%)
		zf-H2C2_2	400..424	CDD:290200	14/23 (61%)
		C2H2 Zn finger	415..435	CDD:275368	7/19 (37%)
		zf-C2H2	441..463	CDD:278523	4/21 (19%)
		C2H2 Zn finger	443..463	CDD:275368	4/19 (21%)
Zfp316	NP_001100591.1	KRAB	151..211	CDD:214630
		KRAB	151..190	CDD:279668
		COG5048	<335..495	CDD:227381
		C2H2 Zn finger	339..359	CDD:275368
		C2H2 Zn finger	367..387	CDD:275368
		zf-C2H2	367..387	CDD:278523
		zf-H2C2_2	379..404	CDD:290200
		C2H2 Zn finger	395..415	CDD:275368
		zf-H2C2_2	407..432	CDD:290200
		C2H2 Zn finger	423..443	CDD:275368
		zf-H2C2_2	435..460	CDD:290200
		C2H2 Zn finger	451..471	CDD:275368
		zf-H2C2_2	463..486	CDD:290200
		C2H2 Zn finger	479..497	CDD:275368
		C2H2 Zn finger	707..727	CDD:275368	8/19 (42%)
		zf-H2C2_2	719..744	CDD:290200	10/73 (14%)
		C2H2 Zn finger	735..755	CDD:275368	8/19 (42%)
		zf-H2C2_2	747..772	CDD:290200	15/24 (63%)
		COG5048	<760..947	CDD:227381	74/203 (36%)
		C2H2 Zn finger	763..783	CDD:275368	6/19 (32%)
		zf-H2C2_2	775..800	CDD:290200	12/24 (50%)
		C2H2 Zn finger	791..811	CDD:275368	8/19 (42%)
		C2H2 Zn finger	819..839	CDD:275368	7/19 (37%)
		zf-C2H2	845..867	CDD:278523	11/23 (48%)
		C2H2 Zn finger	847..867	CDD:275368	11/21 (52%)
		zf-H2C2_2	859..884	CDD:290200	14/24 (58%)
		C2H2 Zn finger	875..895	CDD:275368	7/19 (37%)
		zf-H2C2_2	887..912	CDD:290200	8/24 (33%)
		C2H2 Zn finger	903..923	CDD:275368	4/19 (21%)
		zf-H2C2_2	916..940	CDD:290200	6/38 (16%)
		C2H2 Zn finger	931..951	CDD:275368	3/19 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910