DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kr-h1 and Zbtb41

DIOPT Version :9

Sequence 1:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_001178599.1	Gene:	Zbtb41 / 289052	RGDID:	1560834	Length:	908	Species:	Rattus norvegicus

Alignment Length:	722	Identity:	163/722 - (22%)
Similarity:	255/722 - (35%)	Gaps:	245/722 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 KKSGTELLDISKSPAKAVAVKKSPAKDSATTKMVYYSANQLLIKTEQSSQAQFCLQVPPPLTATT 87
            ||.|.::|:.|.|..::...:|.|.|...|:            ..||.|
  Rat   238 KKHGLKMLERSFSTRRSKRNRKCPVKFDDTS------------DDEQES---------------- 274

  Fly    88 TSVGLGVPPSGGQQEHFELLQTPQQRQ----MQLQLQDQHQQEQQQFVSYQLAIQQHQKQQQQQQ 148
                 |.......||.|:..::.:...    ....::|:..:|:         :...:...:|..
  Rat   275 -----GDGSDNLNQESFDKERSDRNDSEDPGSDYNVEDEELEEE---------VSDEESDTEQSD 325

  Fly   149 HESITNAAPTAAPSAQRI-----------------------KT-EPVGGFPASAAVVSQVRKPSA 189
            .::.....|.||.||..|                       || :.:|.:.      |..|..:.
  Rat   326 KDNDAEEEPEAADSAGSIHEGLAPVVIQNSNKKILQCPKCDKTFDRIGKYE------SHTRVHTG 384

  Fly   190 SKPQFKCDQCGMTFGSKSAHTSHTKSHSKNQDLSLN----------GASGAGVAAPVSTAAIELN 244
            .|| |:||.|...:.:||..|.|.|.||...:....          .||...:|..|.....|
  Rat   385 EKP-FECDICHQRYSTKSNLTVHRKKHSSEVEFHKKEHKCPYCNKLHASKKTLAKHVKRFHPE-- 446

  Fly   245 DAGLPVGIPKSPTIKPLANVAAGADPYQCNVCQKTFAVPARLIRHYRTHTGERPFECEFCHKLF- 308
            :|...:.|.|:.           ::.::|::|:|:|.....|..|...|:.::||:|.:|.:.|
  Rat   447 NAQEFISIKKTK-----------SESWKCDICKKSFTRRPHLEEHMILHSQDKPFKCTYCEEHFK 500

  Fly   309 -----------------------------------------------------SVKE--NLQVHR 318
                                                                 ||:|  .|:.|.
  Rat   501 SRFARLKHQEKFHLGPFPCDICGRQFNDTGNLKRHIECTHGGKRKWTCFICGKSVRERTTLKEHL 565

  Fly   319 RIHTKERPYKCDVCGRAFEHSGKLHRHMRIHTGERPHKCSVCEKTFIQSGQLVIHMRTHTGEKPY 383
            |||:.|:|:.|.:||::|.|......|:|:|..::.::|..|.||||:...|..|.:.|:|||.:
  Rat   566 RIHSGEKPHLCSICGQSFRHGSSYRLHLRVHHDDKRYECDECGKTFIRHDHLTKHKKIHSGEKAH 630

  Fly   384 KCPEPGCGKGF-------------------------------TCSK------QLKVHSRTHTGEK 411
            :|.|  |||.|                               .|.|      .|::|.|||:|||
  Rat   631 QCEE--CGKCFGRRDHLTVHYKSVHLGEKVWQKYKATFHQCDVCKKIFKGKSSLEMHFRTHSGEK 693

  Fly   412 PYHCDICFRDFGYNHVLKLHRVQHYGSKCYKCTICDETFKNKKEMEAHIKG-HANEVPDDEAEAA 475
            ||.|.||.:.|.....|..|.|.|..::.:.|..|:.|||.|.:::.||.. |..:.|||..
  Rat   694 PYKCQICNQSFRIKKTLTKHLVIHSDARPFNCQHCNATFKRKDKLKYHIDHVHGIKSPDDSL--- 755

  Fly   476 AASAAASTSAGSSAGSPSLQGVSSNSESSNHSPPSSPPATKKPRQAR------QPRV----SKT- 529
                                   |.||....|.|....:..|..||.      ||:|    :||
  Rat   756 -----------------------STSEEKLMSLPIEYSSDDKIFQAETKQYLDQPKVYQSEAKTM 797

  Fly   530 ---VAATLSIPTSSPLSPSSLSSTYSPSASSMASPPPTSAHYLPVQME-------ADALSRDSGV 584
               |:|.:.:|.:  |.|..:..|.|...|...:.|.:|...||.|.:       ||....:...
  Rat   798 LQNVSAEVCVPVT--LVPVQMPDTSSDLVSHTTTLPTSSHEMLPPQTQPTDYPRAADLAFLEKYT 860

  Fly   585 SSAQPAH 591
            .:.|||:
  Rat   861 LTPQPAN 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	8/19 (42%)
		COG5048	<270..420	CDD:227381	63/242 (26%)
		zf-C2H2	271..293	CDD:278523	6/21 (29%)
		C2H2 Zn finger	273..293	CDD:275368	6/19 (32%)
		zf-H2C2_2	286..309	CDD:290200	8/76 (11%)
		C2H2 Zn finger	301..321	CDD:275368	9/75 (12%)
		zf-H2C2_2	313..338	CDD:290200	11/24 (46%)
		C2H2 Zn finger	329..349	CDD:275368	7/19 (37%)
		zf-H2C2_2	344..366	CDD:290200	8/21 (38%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		zf-H2C2_2	370..396	CDD:290200	12/56 (21%)
		C2H2 Zn finger	385..407	CDD:275368	11/58 (19%)
		zf-H2C2_2	400..424	CDD:290200	14/23 (61%)
		C2H2 Zn finger	415..435	CDD:275368	7/19 (37%)
		zf-C2H2	441..463	CDD:278523	8/22 (36%)
		C2H2 Zn finger	443..463	CDD:275368	8/20 (40%)
Zbtb41	NP_001178599.1	BTB	78..174	CDD:279045
		BTB	90..174	CDD:197585
		C2H2 Zn finger	362..382	CDD:275368	5/25 (20%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	423..441	CDD:275368	3/17 (18%)
		C2H2 Zn finger	464..484	CDD:275368	6/19 (32%)
		C2H2 Zn finger	492..509	CDD:275368	3/16 (19%)
		C2H2 Zn finger	519..540	CDD:275368	0/20 (0%)
		C2H2 Zn finger	548..568	CDD:275368	6/19 (32%)
		zf-H2C2_2	561..585	CDD:290200	11/23 (48%)
		C2H2 Zn finger	576..596	CDD:275368	7/19 (37%)
		zf-C2H2	602..624	CDD:278523	8/21 (38%)
		C2H2 Zn finger	604..624	CDD:275368	8/19 (42%)
		zf-H2C2_2	616..641	CDD:290200	12/26 (46%)
		C2H2 Zn finger	632..650	CDD:275368	6/19 (32%)
		C2H2 Zn finger	669..686	CDD:275368	3/16 (19%)
		zf-H2C2_2	681..704	CDD:290200	13/22 (59%)
		C2H2 Zn finger	697..717	CDD:275368	7/19 (37%)
		C2H2 Zn finger	725..742	CDD:275368	6/16 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000