DRSC/TRiP Functional Genomics Resources

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Protein Alignment Kr-h1 and Gfi1

DIOPT Version :9

Sequence 1:NP_477466.1 Gene:Kr-h1 / 33861 FlyBaseID:FBgn0266450 Length:845 Species:Drosophila melanogaster
Sequence 2:NP_036698.1 Gene:Gfi1 / 24388 RGDID:2680 Length:423 Species:Rattus norvegicus


Alignment Length:455 Identity:123/455 - (27%)
Similarity:194/455 - (42%) Gaps:61/455 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 PKQIWIKDVLKKSGTELLDISKSPAKAVAVKKSPAKDSATTKMVYYSANQLLIKTEQSSQAQFCL 77
            |:...:|.  ||:.:.....|..|..::.::..|....|....|....:::..:...|.::|. .
  Rat     2 PRSFLVKS--KKAHSYHQPRSPGPDYSLRLETVPVPGRADGGAVSAGESKMEPRERLSPESQL-T 63

  Fly    78 QVPPPLTATTTSV-GLGVPPSGGQQEHFELLQ---TPQQRQMQLQLQDQHQQEQQQFVSYQLA-- 136
            :.|...:|:..|. |....||...::::....   :|...:...:..|:.|.....|..|..:  
  Rat    64 EAPDRASASPNSCEGSVCDPSSEFEDYWRPPSPSVSPASEKSLCRSLDEAQPYTLPFKPYAWSGL 128

  Fly   137 --------IQQHQKQQQQQQHESIT----NAAPTAAPSAQRIKTEPVGGFPASAAVVSQVRKPSA 189
                    :|.:::....::...::    ..|.:..|:|:....:..||             ..|
  Rat   129 AGSDLRHLVQSYRQCSALERSAGLSLFCERGAESGRPAARYGSEQAAGG-------------AGA 180

  Fly   190 SKPQFKCDQCGMTFGSKSAHTSHTKSHSKNQDLSLNG---ASGAGVAAPVSTAAIEL-NDAGLPV 250
            .:|    ..||...|:.||           ..|.|.|   .:.||:....||||..| .|.|..:
  Rat   181 GQP----GSCGAASGATSA-----------GGLGLYGDFAPAAAGLFERPSTAAGRLYQDRGHEL 230

  Fly   251 GIPKSPTIKP-----LANVAAGADPYQCNVCQKTFAVPARLIRHY-RTHTGERPFECEFCHKLFS 309
            ...||..:|.     ...:..|...|:|..|.|.|:.|..|..|. |:|:|.|||.||.|.|.|.
  Rat   231 HADKSVGVKVESELLCTRLLLGGGSYKCIKCSKVFSTPHGLEVHVRRSHSGTRPFACEMCGKTFG 295

  Fly   310 VKENLQVHRRIHTKERPYKCDVCGRAFEHSGKLHRHMRIHTGERPHKCSVCEKTFIQSGQLVIHM 374
            ...:|:.|:.:|::||.:.|.:||::|:.|..|..|:.||:..||:.|..|.|.|.|...:..|.
  Rat   296 HAVSLEQHKAVHSQERSFDCKICGKSFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHT 360

  Fly   375 RTHTGEKPYKCPEPGCGKGFTCSKQLKVHSRTHTGEKPYHCDICFRDFGYNHVLKLHRVQHYGSK 439
            ..||||||:||..  |||.|:.|..|..|||.|||.||:.||:|.:.|.....|:.||...:|.|
  Rat   361 FIHTGEKPHKCQV--CGKAFSQSSNLITHSRKHTGFKPFGCDLCGKGFQRKVDLRRHRETQHGLK 423

  Fly   440  439
              Rat   424  423

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Kr-h1NP_477466.1 C2H2 Zn finger 196..216 CDD:275368 5/19 (26%)
COG5048 <270..420 CDD:227381 66/150 (44%)
zf-C2H2 271..293 CDD:278523 9/22 (41%)
C2H2 Zn finger 273..293 CDD:275368 8/20 (40%)
zf-H2C2_2 286..309 CDD:290200 12/23 (52%)
C2H2 Zn finger 301..321 CDD:275368 7/19 (37%)
zf-H2C2_2 313..338 CDD:290200 9/24 (38%)
C2H2 Zn finger 329..349 CDD:275368 7/19 (37%)
zf-H2C2_2 344..366 CDD:290200 9/21 (43%)
C2H2 Zn finger 357..377 CDD:275368 6/19 (32%)
zf-H2C2_2 370..396 CDD:290200 13/25 (52%)
C2H2 Zn finger 385..407 CDD:275368 10/21 (48%)
zf-H2C2_2 400..424 CDD:290200 13/23 (57%)
C2H2 Zn finger 415..435 CDD:275368 7/19 (37%)
zf-C2H2 441..463 CDD:278523
C2H2 Zn finger 443..463 CDD:275368
Gfi1NP_036698.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..102 18/102 (18%)
SNAG domain. /evidence=ECO:0000250 1..20 4/19 (21%)
Required for interaction with RELA. /evidence=ECO:0000250 141..258 29/144 (20%)
COG5048 <255..417 CDD:227381 69/163 (42%)
C2H2 Zn finger 258..279 CDD:275368 8/20 (40%)
C2H2 Zn finger 287..307 CDD:275368 7/19 (37%)
zf-H2C2_2 299..324 CDD:290200 9/24 (38%)
C2H2 Zn finger 315..335 CDD:275368 7/19 (37%)
C2H2 Zn finger 343..363 CDD:275368 6/19 (32%)
zf-H2C2_2 355..380 CDD:290200 13/26 (50%)
C2H2 Zn finger 371..391 CDD:275368 10/21 (48%)
C2H2 Zn finger 399..418 CDD:275368 7/18 (39%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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