DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kr-h1 and ZNF652

DIOPT Version :9

Sequence 1:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_001138837.1	Gene:	ZNF652 / 22834	HGNCID:	29147	Length:	606	Species:	Homo sapiens

Alignment Length:	611	Identity:	140/611 - (22%)
Similarity:	231/611 - (37%)	Gaps:	148/611 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KSWAPKQIWIKDVLKKSGTELLDISKSP----AKAV----AVKKSPAKDSAT---TKMVYYSANQ 62
            :|.:|..:.:.  .|.|...|.:..:.|    .:||    |||:.......|   .:.|.|...|
Human    54 ESGSPYSVLVD--TKMSKPHLHETEEQPYFRETRAVSDVHAVKEDRENSDDTEEEEEEVSYKREQ 116

  Fly    63 LLIKTEQSSQAQFCLQVPPPLTATTTSVGLGVPPSGGQQEHFELLQTPQQRQMQLQLQDQHQQEQ 127
            ::::...::|              |.:|..|......|.:...:|:|..:.      :::..:|:
Human   117 IIVEVNLNNQ--------------TLNVSKGEKGVSSQSKETPVLKTSSEE------EEEESEEE 161

  Fly   128 QQFVSYQLAIQQHQKQQ----------QQQQHESITNAAPTAAPS-----AQRIKTEPVGGFP-- 175
            ....|......:.||::          |::...:.:.||.|.:|:     .:|...||    |
Human   162 ATDDSNDYGENEKQKKKEKIVEKVSVTQRRTRRAASVAAATTSPTPRTTRGRRKSVEP----PKR 222

  Fly   176 ---ASAAVVSQVRKPSA-SKPQFKCDQCGMTFGSKSAHTSHTK-SHSKNQ-------------DL 222
               |:....:.|:|... .|....|::|...|.::.....|.. :|.:.|             :|
Human   223 KKRATKEPKAPVQKAKCEEKETLTCEKCPRVFNTRWYLEKHMNVTHRRMQICDKCGKKFVLESEL 287

  Fly   223 SLNGASGAGVAAPVSTAAIELNDAGLPVGIPKSPTIKPLANVAAG--ADPYQCNVCQKTFAVPAR 285
            ||:..:.    ...:...:..|.:     ..|..::.....:..|  ...:.|.:|:|.|...|.
Human   288 SLHQQTD----CEKNIQCVSCNKS-----FKKLWSLHEHIKIVHGYAEKKFSCEICEKKFYTMAH 343

  Fly   286 LIRHYRTHTGERPFECEFCHKLFSVKENLQVHRRIHTKERPYKCDVCGRAFEHSGKLHRHMRIHT 350
            :.:|...||.:.||.||.|.|.|....:|:||...|:.|:|::|:.|...|::..:|..||.||.
Human   344 VRKHMVAHTKDMPFTCETCGKSFKRSMSLKVHSLQHSGEKPFRCENCDERFQYKYQLRSHMSIHI 408

  Fly   351 GERPHKCSVCEKTFIQSGQLVIHMRTHTGEKPYKCPEPGCGKGFTCSKQLKVHSRTHTGEKPYHC 415
            |.:...|..|.|.|........||:|||||||:.|..  |||.||....:|.|.|||||||||.|
Human   409 GHKQFMCQWCGKDFNMKQYFDEHMKTHTGEKPFICEI--CGKSFTSRPNMKRHRRTHTGEKPYPC 471

  Fly   416 DICFRDFGYNHVLKLHRVQHYGSKCYKCTICDETFKNKKEMEAHIKGHANEVPDDEAEAAAASAA 480
            |:|.:.|.::::||.|:     .||::.|                 ...|..|..:.....:.|.
Human   472 DVCGQRFRFSNMLKAHK-----EKCFRVT-----------------SPVNVPPAVQIPLTTSPAT 514

  Fly   481 ASTSAGSSAGSPSLQGVSSNSESSNHSPPSSPPATKKPRQARQPRVSKTVAATLSIPTSSPLSPS 545
            ...|..::|.:|                  :||....|.....||           |...|.|..
Human   515 PVPSVVNTATTP------------------TPPINMNPVSTLPPR-----------PIPHPFSHL 550

  Fly   546 SLSSTYSPSASSMASPPPTSAHYLPV 571
            .:            .|.|...|:||:
Human   551 HI------------HPHPHHPHHLPI 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	4/20 (20%)
		COG5048	<270..420	CDD:227381	63/149 (42%)
		zf-C2H2	271..293	CDD:278523	6/21 (29%)
		C2H2 Zn finger	273..293	CDD:275368	6/19 (32%)
		zf-H2C2_2	286..309	CDD:290200	9/22 (41%)
		C2H2 Zn finger	301..321	CDD:275368	8/19 (42%)
		zf-H2C2_2	313..338	CDD:290200	9/24 (38%)
		C2H2 Zn finger	329..349	CDD:275368	6/19 (32%)
		zf-H2C2_2	344..366	CDD:290200	9/21 (43%)
		C2H2 Zn finger	357..377	CDD:275368	6/19 (32%)
		zf-H2C2_2	370..396	CDD:290200	14/25 (56%)
		C2H2 Zn finger	385..407	CDD:275368	9/21 (43%)
		zf-H2C2_2	400..424	CDD:290200	15/23 (65%)
		C2H2 Zn finger	415..435	CDD:275368	7/19 (37%)
		zf-C2H2	441..463	CDD:278523	1/21 (5%)
		C2H2 Zn finger	443..463	CDD:275368	1/19 (5%)
ZNF652	NP_001138837.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..113		9/41 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	130..235		19/114 (17%)
		UFD1	<240..304	CDD:332114	10/67 (15%)
		C2H2 Zn finger	247..266	CDD:275368	4/18 (22%)
		C2H2 Zn finger	274..293	CDD:275368	3/18 (17%)
		C2H2 Zn finger	301..321	CDD:275368	2/24 (8%)
		C2H2 Zn finger	331..351	CDD:275368	6/19 (32%)
		C2H2 Zn finger	359..379	CDD:275368	8/19 (42%)
		SFP1	<381..464	CDD:227516	34/84 (40%)
		C2H2 Zn finger	387..407	CDD:275368	6/19 (32%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		COG5048	439..>488	CDD:227381	25/50 (50%)
		C2H2 Zn finger	443..463	CDD:275368	9/21 (43%)
		C2H2 Zn finger	471..487	CDD:275368	6/15 (40%)
		Mediates interaction with CBFA2T3. /evidence=ECO:0000269\|PubMed:16966434	498..606		19/108 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000