DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kr-h1 and ZNF467

DIOPT Version :9

Sequence 1:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	XP_011514159.1	Gene:	ZNF467 / 168544	HGNCID:	23154	Length:	809	Species:	Homo sapiens

Alignment Length:	623	Identity:	139/623 - (22%)
Similarity:	205/623 - (32%)	Gaps:	223/623 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 TSVG--LGVPPSGGQQEHFELLQTPQQRQMQLQLQDQHQQEQ--------QQFVSYQLAIQQHQK 142
            :|:|  :|.|....|.|       |::.....|.|....:|:        ::::..::.::...:
Human   260 SSLGFSVGQPEMAPQSE-------PREGSHNAQEQMSSSREERALGVCSGEEWMIRKVKVEDEDQ 317

  Fly   143 QQQQQ----QHESITNAAPTAAPS----AQRIKTEPVGGFP-ASAAVVSQVRKPSASKP------ 192
            :.:::    ||.|:. .:|..||.    |...|.||  |.| |.:.:......|...||
Human   318 EAEEEVEWPQHLSLL-PSPFPAPDLGHLAAAYKLEP--GAPGALSGLALSGWGPMPEKPYGCGEC 379

  Fly   193 --QFK-------------------CDQCGMTFGSKSAHTSHTKSHSKNQDLSLNGASGAGVAAPV 236
              :|:                   |..||.:|..::....|.:||
Human   380 ERRFRDQLTLRLHQRLHRGEGPCACPDCGRSFTQRAHMLLHQRSH-------------------- 424

  Fly   237 STAAIELNDAGLPVGIPKSPTIKPLANVAAGADPYQCNVCQKTFAVPARLIRHYRTHTGERPFEC 301
                                         .|..|:.|:.|.|.|:..|.|.||.||||||||:.|
Human   425 -----------------------------RGERPFPCSECDKRFSKKAHLTRHLRTHTGERPYPC 460

  Fly   302 EFCHKLFSVKENLQVHRRIHTKERPYKCDVCGRAFEHSGKLHRHMRIHTGERPHKCSVCEKTFIQ 366
            ..|.|.||.|.:|..|::.||.|||:.|..|.:.|.....|.||.||||||||::|:.|.::|..
Human   461 AECGKRFSQKIHLGSHQKTHTGERPFPCTECEKRFRKKTHLIRHQRIHTGERPYQCAQCARSFTH 525

  Fly   367 SGQLVIHMRTH---------------------------TGEKPYKCPE----------------- 387
            ...||.|.|.|                           .|.||:.|.:
Human   526 KQHLVRHQRVHQTAGPARPSPDSSASPHSTAPSPTPSFPGPKPFACSDCGLSFGWKKNLATHQCL 590

  Fly   388 ---------------------------------------------------------PGCGKGFT 395
                                                                     |.||:||:
Human   591 HRSEGRPFGCDECALGATVDAPAAKPLASAPGGPGCGPGSDPVVPQRAPSGERSFFCPDCGRGFS 655

  Fly   396 CSKQLKVHSRTHTGEKPYHCDICFRDFGYNHVLKLHRVQHYGSKCYKCTICDETFKNKKEMEAHI 460
            ..:.|..|.|.||||:|:.|..|.|.||....|..|...|.|::.:.|..|...|..|..:..|.
Human   656 HGQHLARHPRVHTGERPFACTQCDRRFGSRPNLVAHSRAHSGARPFACAQCGRRFSRKSHLGRHQ 720

  Fly   461 KGHANEVPDDEAEAAAASAAASTSAGSSAGSPSLQGVSSNSESSNHSPPSSPPATKKPRQARQPR 525
            ..|....|.       |.|..:.|..|.......|.:.:.|.     |.|.|...|.     ..|
Human   721 AVHTGSRPH-------ACAVCARSFSSKTNLVRHQAIHTGSR-----PFSCPQCGKS-----FSR 768

  Fly   526 VSKTVAATLSIPTSSPLSPSSLSSTYSPSASSMASPPP 563
            .:..|...|....::..:|.:..:..:.||....:|||
Human   769 KTHLVRHQLIHGEAAHAAPDAALAAPAWSAPPEVAPPP 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	5/19 (26%)
		COG5048	<270..420	CDD:227381	71/250 (28%)
		zf-C2H2	271..293	CDD:278523	9/21 (43%)
		C2H2 Zn finger	273..293	CDD:275368	9/19 (47%)
		zf-H2C2_2	286..309	CDD:290200	14/22 (64%)
		C2H2 Zn finger	301..321	CDD:275368	8/19 (42%)
		zf-H2C2_2	313..338	CDD:290200	10/24 (42%)
		C2H2 Zn finger	329..349	CDD:275368	7/19 (37%)
		zf-H2C2_2	344..366	CDD:290200	13/21 (62%)
		C2H2 Zn finger	357..377	CDD:275368	7/19 (37%)
		zf-H2C2_2	370..396	CDD:290200	14/126 (11%)
		C2H2 Zn finger	385..407	CDD:275368	9/95 (9%)
		zf-H2C2_2	400..424	CDD:290200	12/23 (52%)
		C2H2 Zn finger	415..435	CDD:275368	7/19 (37%)
		zf-C2H2	441..463	CDD:278523	5/21 (24%)
		C2H2 Zn finger	443..463	CDD:275368	5/19 (26%)
ZNF467	XP_011514159.1	C2H2 Zn finger	376..396	CDD:275368	1/19 (5%)
		zf-H2C2_2	389..413	CDD:290200	4/23 (17%)
		COG5048	404..779	CDD:227381	106/440 (24%)
		C2H2 Zn finger	404..424	CDD:275368	5/19 (26%)
		zf-H2C2_2	416..440	CDD:290200	8/72 (11%)
		zf-C2H2	430..452	CDD:278523	9/21 (43%)
		C2H2 Zn finger	432..452	CDD:275368	9/19 (47%)
		zf-H2C2_2	444..469	CDD:290200	15/24 (63%)
		C2H2 Zn finger	460..480	CDD:275368	8/19 (42%)
		zf-H2C2_2	472..495	CDD:290200	9/22 (41%)
		C2H2 Zn finger	488..508	CDD:275368	7/19 (37%)
		zf-H2C2_2	500..525	CDD:290200	14/24 (58%)
		C2H2 Zn finger	516..536	CDD:275368	7/19 (37%)
		C2H2 Zn finger	571..591	CDD:275368	1/19 (5%)
		C2H2 Zn finger	647..667	CDD:275368	8/19 (42%)
		zf-H2C2_2	659..682	CDD:290200	11/22 (50%)
		C2H2 Zn finger	675..695	CDD:275368	7/19 (37%)
		C2H2 Zn finger	703..723	CDD:275368	5/19 (26%)
		C2H2 Zn finger	731..751	CDD:275368	4/19 (21%)
		zf-H2C2_2	743..768	CDD:290200	6/34 (18%)
		C2H2 Zn finger	759..779	CDD:275368	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910