DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kr-h1 and ZNF362

DIOPT Version :9

Sequence 1:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_001357141.1	Gene:	ZNF362 / 149076	HGNCID:	18079	Length:	420	Species:	Homo sapiens

Alignment Length:	403	Identity:	108/403 - (26%)
Similarity:	175/403 - (43%)	Gaps:	54/403 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 PPPLTATTTSVGLGVPPSGGQQEHFELLQTPQQRQMQLQLQDQH-----QQEQQQFVSYQLAIQQ 139
            |||            |....|.::..|:...:::.|..:::..|     ...||..:......:.
Human    26 PPP------------PTMPSQLDNLVLINKIKEQLMAEKIRPPHLPPTSASSQQPLLVPPAPAES 78

  Fly   140 HQKQQQQQQHESITNAAPTAAPSAQ-----RIKTEPVGGFPASAAVVSQVRKPSASKPQFKCDQC 199
            .|......:.:.:....|.|.|...     |..|..|.|...|      .|.||.|..:.... .
Human    79 SQAVMSLPKLQQVPGLHPQAVPQPDVALHARPATSTVTGLGLS------TRTPSVSTSESSAG-A 136

  Fly   200 GMTFGSKSAHTSHTKSHSKNQDLSLNGASG---AGVAAPVSTAAIE-LNDAGLPVGIPKSPT-IK 259
            |...|:.:..|..|.|.|:     |..:|.   :|:.:|....:|: :...|| :|.|||.. .|
Human   137 GTGTGTSTPSTPTTTSQSR-----LIASSPTLISGITSPPLLDSIKTIQGHGL-LGPPKSERGRK 195

  Fly   260 PLANVAAGADPYQCNVCQKTFAVPARLIRHYRTHTGERPFECEFCHKLFSVKENLQVHRRIHTKE 324
            .:.....|..|        ...||..::....|....:.:.|:.|...|..|..:|:|.:.||:.
Human   196 KIKAENPGGPP--------VLVVPYPILASGETAKEGKTYRCKVCPLTFFTKSEMQIHSKSHTEA 252

  Fly   325 RPYKCDVCGRAFEHSGKLHRHMRIHTGERPHKCSVCEKTFIQSGQLVIHMRTHTGEKPYKCPEPG 389
            :|:||..|.::|.::..|.:|:|||.|.:|:.||.|:|:|.|...|..|.|.|||::|||||.||
Human   253 KPHKCPHCSKSFANASYLAQHLRIHLGVKPYHCSYCDKSFRQLSHLQQHTRIHTGDRPYKCPHPG 317

  Fly   390 CGKGFTCSKQLKVHSRTHTGEKPYHCDICFRDFGYNHVLKL----HRVQHYGSKCYKCTICDETF 450
            |.|.||....|:.|.|.|..:|||.|..|:|.:..:..|::    |.::|  :|.|.|::|...:
Human   318 CEKAFTQLSNLQSHQRQHNKDKPYKCPNCYRAYSDSASLQIHLSAHAIKH--AKAYCCSMCGRAY 380

  Fly   451 KNKKEMEAHIKGH 463
            .::..:..|:..|
Human   381 TSETYLMKHMSKH 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	4/19 (21%)
		COG5048	<270..420	CDD:227381	56/149 (38%)
		zf-C2H2	271..293	CDD:278523	2/21 (10%)
		C2H2 Zn finger	273..293	CDD:275368	2/19 (11%)
		zf-H2C2_2	286..309	CDD:290200	3/22 (14%)
		C2H2 Zn finger	301..321	CDD:275368	6/19 (32%)
		zf-H2C2_2	313..338	CDD:290200	9/24 (38%)
		C2H2 Zn finger	329..349	CDD:275368	6/19 (32%)
		zf-H2C2_2	344..366	CDD:290200	11/21 (52%)
		C2H2 Zn finger	357..377	CDD:275368	9/19 (47%)
		zf-H2C2_2	370..396	CDD:290200	16/25 (64%)
		C2H2 Zn finger	385..407	CDD:275368	11/21 (52%)
		zf-H2C2_2	400..424	CDD:290200	10/23 (43%)
		C2H2 Zn finger	415..435	CDD:275368	5/23 (22%)
		zf-C2H2	441..463	CDD:278523	4/21 (19%)
		C2H2 Zn finger	443..463	CDD:275368	3/19 (16%)
ZNF362	NP_001357141.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		1/1 (100%)
		PRK14971	<27..>125	CDD:237874	19/115 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	54..80		3/25 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	115..155		12/46 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..202		7/24 (29%)
		C2H2 Zn finger	229..249	CDD:275368	6/19 (32%)
		zf-H2C2_2	241..266	CDD:372612	9/24 (38%)
		zf-C2H2	255..277	CDD:333835	7/21 (33%)
		C2H2 Zn finger	257..277	CDD:275368	6/19 (32%)
		zf-H2C2_2	269..294	CDD:372612	12/24 (50%)
		C2H2 Zn finger	285..305	CDD:275368	9/19 (47%)
		SFP1	<307..359	CDD:227516	23/51 (45%)
		C2H2 Zn finger	313..335	CDD:275368	11/21 (52%)
		C2H2 Zn finger	343..363	CDD:275368	4/19 (21%)
		C2H2 Zn finger	375..393	CDD:275368	2/17 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000