DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kr-h1 and ZNF417

DIOPT Version :9

Sequence 1:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	XP_011524775.1	Gene:	ZNF417 / 147687	HGNCID:	20646	Length:	643	Species:	Homo sapiens

Alignment Length:	468	Identity:	135/468 - (28%)
Similarity:	195/468 - (41%)	Gaps:	93/468 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VLKKSGTELLDISKSPAKAVAVKKSPAKDSATTKMVYYSANQLLIKTEQSSQAQFCLQVPPPLTA 85
            |.::.|.::|..|....:|.||:|:   ||.|..                         .||...
Human   239 VFREFGKDVLPSSGLCQEAAAVEKT---DSETMH-------------------------GPPFQE 275

  Fly    86 TTTSVGLGVPPSGGQQEHFELLQTPQQRQMQLQLQD-------------------QHQQEQQQFV 131
            ..|:...|........:|..:   |.|:   |..:|                   .||::.....
Human   276 GKTNYSCGKRTKAFSTKHSVI---PHQK---LFTRDGCYVCSDCGKSFSRYVSFSNHQRDHTAKG 334

  Fly   132 SYQLAI--QQHQKQQQQQQHESITNAAPTAAPSAQRIKTEPVGGFPASAAVVSQVRKPSASKPQF 194
            .|....  :.:.::....||:.: :...||.|..:..|:     |....:::|..|..:..:| :
Human   335 PYDCGECGKSYSRKSSLIQHQRV-HTGKTAYPCEECGKS-----FSQKGSLISHQRVHTGERP-Y 392

  Fly   195 KCDQCGMTFGSKSAHTSHTKSHSKNQDLSLNGASGAGVAAPVSTAAIELNDAGLPVGIPKSPTIK 259
            :|.:.|.:||.|.....|.:.|:..:                   |....:.|      ||...|
Human   393 ECREYGKSFGQKGNLIQHQQGHTGER-------------------AYHCGECG------KSFRQK 432

  Fly   260 ----PLANVAAGADPYQCNVCQKTFAVPARLIRHYRTHTGERPFECEFCHKLFSVKENLQVHRRI 320
                ....|..|..||:|..|.|:|.....|::|.|.||||||:||:.|.|.|..:.:|..|:|:
Human   433 FCFINHQRVHTGERPYKCGECGKSFGQKGNLVQHQRGHTGERPYECKECGKSFRYRSHLTEHQRL 497

  Fly   321 HTKERPYKCDVCGRAFEHSGKLHRHMRIHTGERPHKCSVCEKTFIQSGQLVIHMRTHTGEKPYKC 385
            ||.||||.|..||:.|.....|..|.|:||||||:.|.||.|.|.....:.||.|.||||:||:|
Human   498 HTGERPYNCRECGKLFNRKYHLLVHERVHTGERPYACEVCGKLFGNKNCVTIHQRIHTGERPYEC 562

  Fly   386 PEPGCGKGFTCSKQLKVHSRTHTGEKPYHCDICFRDFGYNHVLKLHRVQHYGSKCYKCTICDETF 450
            .|  |||.|..|..|.||.|.|:|:|||.|..|.:.|.....|..||..|.|.:.|:||.|.:||
Human   563 NE--CGKSFLSSSALHVHKRVHSGQKPYKCSECGKSFAECSSLIKHRRIHTGERPYECTKCGKTF 625

  Fly   451 KNKKEMEAHIKGH 463
            :....:..|...|
Human   626 QRSSTLLHHQSSH 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	6/19 (32%)
		COG5048	<270..420	CDD:227381	74/149 (50%)
		zf-C2H2	271..293	CDD:278523	8/21 (38%)
		C2H2 Zn finger	273..293	CDD:275368	7/19 (37%)
		zf-H2C2_2	286..309	CDD:290200	13/22 (59%)
		C2H2 Zn finger	301..321	CDD:275368	7/19 (37%)
		zf-H2C2_2	313..338	CDD:290200	13/24 (54%)
		C2H2 Zn finger	329..349	CDD:275368	7/19 (37%)
		zf-H2C2_2	344..366	CDD:290200	13/21 (62%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		zf-H2C2_2	370..396	CDD:290200	15/25 (60%)
		C2H2 Zn finger	385..407	CDD:275368	11/21 (52%)
		zf-H2C2_2	400..424	CDD:290200	12/23 (52%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		zf-C2H2	441..463	CDD:278523	7/21 (33%)
		C2H2 Zn finger	443..463	CDD:275368	6/19 (32%)
ZNF417	XP_011524775.1	KRAB	83..138	CDD:214630
		KRAB	83..122	CDD:279668
		C2H2 Zn finger	162..182	CDD:275368
		C2H2 Zn finger	190..210	CDD:275368
		C2H2 Zn finger	282..302	CDD:275368	4/25 (16%)
		C2H2 Zn finger	310..330	CDD:275368	2/19 (11%)
		C2H2 Zn finger	338..358	CDD:275368	2/20 (10%)
		COG5048	<341..636	CDD:227381	111/328 (34%)
		zf-C2H2	364..386	CDD:278523	5/26 (19%)
		C2H2 Zn finger	366..386	CDD:275368	4/24 (17%)
		C2H2 Zn finger	394..411	CDD:275368	5/16 (31%)
		C2H2 Zn finger	422..442	CDD:275368	4/25 (16%)
		zf-H2C2_2	437..457	CDD:290200	7/19 (37%)
		C2H2 Zn finger	450..470	CDD:275368	7/19 (37%)
		zf-H2C2_2	462..487	CDD:290200	14/24 (58%)
		C2H2 Zn finger	478..498	CDD:275368	7/19 (37%)
		zf-H2C2_2	490..515	CDD:290200	13/24 (54%)
		C2H2 Zn finger	506..526	CDD:275368	7/19 (37%)
		zf-H2C2_2	518..541	CDD:290200	13/22 (59%)
		C2H2 Zn finger	534..554	CDD:275368	8/19 (42%)
		zf-H2C2_2	550..571	CDD:290200	14/22 (64%)
		C2H2 Zn finger	562..582	CDD:275368	11/21 (52%)
		zf-H2C2_2	577..598	CDD:290200	10/20 (50%)
		C2H2 Zn finger	590..610	CDD:275368	6/19 (32%)
		zf-H2C2_2	602..625	CDD:290200	9/22 (41%)
		C2H2 Zn finger	618..638	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910