DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kr-h1 and ZNF418

DIOPT Version :9

Sequence 1:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_001303956.1	Gene:	ZNF418 / 147686	HGNCID:	20647	Length:	697	Species:	Homo sapiens

Alignment Length:	496	Identity:	138/496 - (27%)
Similarity:	203/496 - (40%)	Gaps:	99/496 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 GTELLDISKSPAKAVAVKKSPAKDSATTKMVYYSANQLLIKTEQSSQAQFCLQVPPPLTATTTSV 90
            |.:|.|.|..|.:...:.:.|.:.|....:.....     |...|.::...:|           .
Human   137 GNKLYDSSNRPHQNQYLGEKPYRSSVEEALFVKRC-----KFHVSEESSIFIQ-----------S 185

  Fly    91 GLGVPPSGG----QQEHF-ELLQTPQQRQMQLQLQDQHQQ--EQQQFVSYQLAIQQHQKQQQQQQ 148
            |....||.|    :..|. |...:..:.:...|..|.|..  |..:..|.:....|.|:...:::
Human   186 GKDFLPSSGLLLQEATHTGEKSNSKPECESPFQWGDTHYSCGECMKHSSTKHVFVQQQRLPSREE 250

  Fly   149 ------------HESITNAAPTAAPSAQRIKT--------EPVGGFPASAAVVSQVRKPSASKPQ 193
                        ::|::|        .||:.|        |....|....::|...|..:..:|
Human   251 CYCWECGKSFSKYDSVSN--------HQRVHTGKRPYECGECGKSFSHKGSLVQHQRVHTGKRP- 306

  Fly   194 FKCDQCGMTFGSKSAHTSHTKSHSKNQDLSLNGASGAGVAAPVSTAAIELNDAGLPVGIPKSPTI 258
            ::|.:||.:|..|.:...|.:.|:..:                   ..|..:.|  ....::.|:
Human   307 YECGECGKSFSHKGSLVQHQRVHTGER-------------------PYECGECG--KSFSQNGTL 350

  Fly   259 KPLANVAAGADPYQCNVCQKTFAVPARLIRHYRTHTGERPFECEFCHKLFSVKENLQVHRRIHTK 323
            .....|..|..||:|..|.|.|.....||:|.|.||.|||:|||.|.|.||.|..|..|.|:||:
Human   351 IKHQRVHTGERPYECEECGKCFTQKGNLIQHQRGHTSERPYECEECGKCFSQKGTLTEHHRVHTR 415

  Fly   324 ERPYKCDVCGRAFEHSGKLHRHMRIHTGERPHKCSVCEKTFIQSGQLVIHMRTHTGEKPYKCPE- 387
            ||||:|..||::|...|.|..|.|.||||||::|..|.|:|.:.|.|:.|.|:||||:||:|.|
Human   416 ERPYECGECGKSFSRKGHLRNHQRGHTGERPYECGECGKSFSRKGNLIQHQRSHTGERPYECREC 480

  Fly   388 -------------------------PGCGKGFTCSKQLKVHSRTHTGEKPYHCDICFRDFGYNHV 427
                                     ..|||.|..|...:||.|.||||||:.|..|.:.|..:..
Human   481 RKLFRGKSHLIEHQRVHTGERPYECNECGKSFQDSSGFRVHQRVHTGEKPFECSECGKSFPQSCS 545

  Fly   428 LKLHRVQHYGSKCYKCTICDETFKNKKEMEAHIKGHANEVP 468
            |..||..|.|.:.|:|..|.::|.....:..|.|.|..|.|
Human   546 LLRHRRVHTGERPYECGECGKSFHQSSSLLRHQKTHTAERP 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	6/19 (32%)
		COG5048	<270..420	CDD:227381	78/175 (45%)
		zf-C2H2	271..293	CDD:278523	9/21 (43%)
		C2H2 Zn finger	273..293	CDD:275368	8/19 (42%)
		zf-H2C2_2	286..309	CDD:290200	14/22 (64%)
		C2H2 Zn finger	301..321	CDD:275368	10/19 (53%)
		zf-H2C2_2	313..338	CDD:290200	13/24 (54%)
		C2H2 Zn finger	329..349	CDD:275368	8/19 (42%)
		zf-H2C2_2	344..366	CDD:290200	12/21 (57%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		zf-H2C2_2	370..396	CDD:290200	15/51 (29%)
		C2H2 Zn finger	385..407	CDD:275368	10/47 (21%)
		zf-H2C2_2	400..424	CDD:290200	12/23 (52%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		zf-C2H2	441..463	CDD:278523	6/21 (29%)
		C2H2 Zn finger	443..463	CDD:275368	5/19 (26%)
ZNF418	NP_001303956.1	KRAB	26..>67	CDD:214630
		KRAB	26..65	CDD:279668
		C2H2 Zn finger	105..125	CDD:275368
		C2H2 Zn finger	253..273	CDD:275368	4/27 (15%)
		C2H2 Zn finger	281..301	CDD:275368	4/19 (21%)
		zf-H2C2_2	293..318	CDD:290200	7/25 (28%)
		COG5048	304..692	CDD:227381	106/305 (35%)
		C2H2 Zn finger	309..329	CDD:275368	6/19 (32%)
		zf-H2C2_2	321..346	CDD:290200	4/45 (9%)
		C2H2 Zn finger	337..357	CDD:275368	2/21 (10%)
		zf-H2C2_2	350..374	CDD:290200	8/23 (35%)
		C2H2 Zn finger	365..385	CDD:275368	8/19 (42%)
		C2H2 Zn finger	393..413	CDD:275368	10/19 (53%)
		C2H2 Zn finger	421..441	CDD:275368	8/19 (42%)
		zf-H2C2_2	433..458	CDD:290200	13/24 (54%)
		C2H2 Zn finger	449..469	CDD:275368	8/19 (42%)
		C2H2 Zn finger	477..497	CDD:275368	2/19 (11%)
		zf-H2C2_2	489..512	CDD:290200	3/22 (14%)
		C2H2 Zn finger	505..525	CDD:275368	8/19 (42%)
		zf-H2C2_2	518..540	CDD:290200	11/21 (52%)
		C2H2 Zn finger	533..553	CDD:275368	6/19 (32%)
		zf-H2C2_2	545..570	CDD:290200	9/24 (38%)
		C2H2 Zn finger	561..581	CDD:275368	5/19 (26%)
		zf-H2C2_2	573..598	CDD:290200	5/14 (36%)
		C2H2 Zn finger	589..606	CDD:275368
		zf-H2C2_2	598..623	CDD:290200
		C2H2 Zn finger	614..634	CDD:275368
		C2H2 Zn finger	642..662	CDD:275368
		zf-H2C2_2	654..679	CDD:290200
		C2H2 Zn finger	670..690	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000