DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kr-h1 and ZNF358

DIOPT Version :9

Sequence 1:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_060553.4	Gene:	ZNF358 / 140467	HGNCID:	16838	Length:	568	Species:	Homo sapiens

Alignment Length:	513	Identity:	149/513 - (29%)
Similarity:	203/513 - (39%)	Gaps:	140/513 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 KTEPV-GGFPASAAVVS---QVRKPSASKPQ-FKCDQCGMTFGSKSAHTSHTKSHSKNQDLSLNG 226
            |.:|: .|..|:..|::   .|....||.|: |.|..||..|...|..:.|.::||
Human   119 KVDPISSGLTATPQVLATSPAVLPAPASPPRPFSCPDCGRAFRRSSGLSQHRRTHS--------- 174

  Fly   227 ASGAGVAAPVSTAAIELNDAGLPVGIPKSPTIKPLANVAAGADPYQCNVCQKTFAVPARLIRHYR 291
                                                    |..||:|..|.|:|:..|.|.:|..
Human   175 ----------------------------------------GEKPYRCPDCGKSFSHGATLAQHRG 199

  Fly   292 THTGERPFECEFCHKLFSVKENLQVHRRIHTKERPYKCDVCGRAFEHSGKLHRHMRIHTGERPHK 356
            .|||.||::|..|.|.|..:..|..||..|:.|:|:.|.|||:||.|...|.:|:|.|.|.||||
Human   200 IHTGARPYQCAACGKAFGWRSTLLKHRSSHSGEKPHHCPVCGKAFGHGSLLAQHLRTHGGPRPHK 264

  Fly   357 CSVCEKTFIQSGQLVIHMRTHTGEKPYKCPE--------------------------PGCGKGFT 395
            |.||.|.|.|...|:.|:||||||:||.||:                          |.|||.|.
Human   265 CPVCAKGFGQGSALLKHLRTHTGERPYPCPQCGKAFGQSSALLQHQRTHTAERPYRCPHCGKAFG 329

  Fly   396 CSKQLKVHSRTHTGEKPYHCDICFRDFGYNHVLKLHRVQHYGSKCYKCTICDETFKNKKEMEAHI 460
            .|..|:.|.|.||||:||.|..|.:.||.:..|..|...|.|.:.|:|.:|.:.|.....:..|.
Human   330 QSSNLQHHLRIHTGERPYACPHCSKAFGQSSALLQHLHVHSGERPYRCQLCGKAFGQASSLTKHK 394

  Fly   461 KGHANEVPDDEAEAAAASAAASTSAGSSAG---SPSLQ-------------------------GV 497
            :.|       |..||||:|||:.:|.::||   .|.|.                         |:
Human   395 RVH-------EGAAAAAAAAAAAAAAAAAGLGLGPGLSPASMMRPGQVSLLGPDAVSVLGSGLGL 452

  Fly   498 SSNSESSNHSPPSSPPATKKPRQARQPRVSKTVAATLSIPTSSP---------LSPS-SLSSTYS 552
            |..:.|..:..|.|.|.|.....::....|::..:...:.:|.|         |.|| .|....|
Human   453 SPGTSSGRNPDPGSGPGTLPDPSSKPLPGSRSTPSPTPVESSDPKAGHDAGPDLVPSPDLDPVPS 517

  Fly   553 PSASSMASPPPTSAHYLPVQMEADALSRDSGVSSAQPAHSTYADEEPTDLSMQQVQGQ 610
            |....:.||.|.     ||          |......|...|.:...||..|.:.||.|
Human   518 PDPDPVPSPDPN-----PV----------SCPDPCSPTRGTVSPALPTGESPEWVQEQ 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	6/19 (32%)
		COG5048	<270..420	CDD:227381	75/175 (43%)
		zf-C2H2	271..293	CDD:278523	8/21 (38%)
		C2H2 Zn finger	273..293	CDD:275368	7/19 (37%)
		zf-H2C2_2	286..309	CDD:290200	10/22 (45%)
		C2H2 Zn finger	301..321	CDD:275368	7/19 (37%)
		zf-H2C2_2	313..338	CDD:290200	12/24 (50%)
		C2H2 Zn finger	329..349	CDD:275368	10/19 (53%)
		zf-H2C2_2	344..366	CDD:290200	13/21 (62%)
		C2H2 Zn finger	357..377	CDD:275368	9/19 (47%)
		zf-H2C2_2	370..396	CDD:290200	17/51 (33%)
		C2H2 Zn finger	385..407	CDD:275368	11/47 (23%)
		zf-H2C2_2	400..424	CDD:290200	12/23 (52%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		zf-C2H2	441..463	CDD:278523	5/21 (24%)
		C2H2 Zn finger	443..463	CDD:275368	4/19 (21%)
ZNF358	NP_060553.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..117
		COG5048	<35..339	CDD:227381	85/268 (32%)
		lambda-1	108..>174	CDD:212564	16/54 (30%)
		zf-C2H2	151..173	CDD:278523	7/21 (33%)
		C2H2 Zn finger	153..173	CDD:275368	6/19 (32%)
		zf-H2C2_2	166..190	CDD:290200	10/72 (14%)
		C2H2 Zn finger	181..201	CDD:275368	7/19 (37%)
		zf-H2C2_2	194..216	CDD:290200	10/21 (48%)
		C2H2 Zn finger	209..229	CDD:275368	7/19 (37%)
		zf-H2C2_2	222..244	CDD:290200	10/21 (48%)
		C2H2 Zn finger	237..257	CDD:275368	10/19 (53%)
		zf-H2C2_2	250..272	CDD:290200	13/21 (62%)
		C2H2 Zn finger	265..285	CDD:275368	9/19 (47%)
		zf-H2C2_2	277..300	CDD:290200	12/22 (55%)
		zf-C2H2_8	292..370	CDD:292531	23/77 (30%)
		C2H2 Zn finger	293..313	CDD:275368	2/19 (11%)
		zf-H2C2_2	305..328	CDD:290200	4/22 (18%)
		C2H2 Zn finger	321..341	CDD:275368	9/19 (47%)
		zf-H2C2_2	333..356	CDD:290200	11/22 (50%)
		C2H2 Zn finger	349..369	CDD:275368	6/19 (32%)
		zf-H2C2_2	361..384	CDD:290200	7/22 (32%)
		zf-C2H2	375..397	CDD:278523	5/21 (24%)
		C2H2 Zn finger	377..397	CDD:275368	4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	448..568		30/128 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010