DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kr-h1 and Zbtb7a

DIOPT Version :9

Sequence 1:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	XP_006240898.1	Gene:	Zbtb7a / 117107	RGDID:	620946	Length:	648	Species:	Rattus norvegicus

Alignment Length:	319	Identity:	87/319 - (27%)
Similarity:	129/319 - (40%)	Gaps:	78/319 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 NGASGAGVAAPVSTAAIELNDAGLPVGIPKSPTIKPLANVAAGADPYQCNVCQKTFAVPARLIRH 289
            ||..|...|:.....|:.|::|....|  .||..  |:..|.|.|....:|   .....:.|::.
  Rat   342 NGHYGRAGASTGEEEAVALSEAAPEPG--DSPGF--LSGAAEGEDGDAADV---DGLAASTLLQQ 399

  Fly   290 YRTHTG--------ERPFE---CEFCHKLFSVKENLQVH--------RRIHTKERPYKCDVCGRA 335
            ..:..|        .||.:   .::..|.||......|:        ::|..|.. .||.:|.:.
  Rat   400 MMSSVGRAGDSDEESRPDDKGVMDYYLKYFSGAHEGDVYPAWSQKGEKKIRAKAF-QKCPICEKV 463

  Fly   336 FEHSGKLHRHMRIHTGERPHKCSVCEKTFIQSGQLVIHMRTHTGEKPYKCPEPGCGKGFTCSKQL 400
            .:.:|||.||:|.||||:|::|::|:..|.:..:|.:|||.|||||||.|.:  ||..|..:..|
  Rat   464 IQGAGKLPRHIRTHTGEKPYECNICKVRFTRQDKLKVHMRKHTGEKPYLCQQ--CGAAFAHNYDL 526

  Fly   401 KVHSRTHTGEKPYHCDICFRDFGYNHVLKLHRVQHYGSKCYKCTICDETFKNKKEMEAHI-KGHA 464
            |.|.|.|||.:||.||.|                           | :||.....:..|: |...
  Rat   527 KNHMRVHTGLRPYQCDSC---------------------------C-KTFVRSDHLHRHLKKDGC 563

  Fly   465 NEVPDDEAEAAAASAAASTSAGSSAGSPSLQGVSSNSESSNHSPPSSPPATKKPRQARQ 523
            |.||.....                 .|.::||..:..|...:||..|.|   ||..::
  Rat   564 NGVPSRRGR-----------------KPRVRGVPPDVPSGAGAPPGLPDA---PRNGQE 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368
		COG5048	<270..420	CDD:227381	55/168 (33%)
		zf-C2H2	271..293	CDD:278523	2/21 (10%)
		C2H2 Zn finger	273..293	CDD:275368	2/19 (11%)
		zf-H2C2_2	286..309	CDD:290200	5/33 (15%)
		C2H2 Zn finger	301..321	CDD:275368	4/27 (15%)
		zf-H2C2_2	313..338	CDD:290200	6/32 (19%)
		C2H2 Zn finger	329..349	CDD:275368	8/19 (42%)
		zf-H2C2_2	344..366	CDD:290200	11/21 (52%)
		C2H2 Zn finger	357..377	CDD:275368	7/19 (37%)
		zf-H2C2_2	370..396	CDD:290200	15/25 (60%)
		C2H2 Zn finger	385..407	CDD:275368	8/21 (38%)
		zf-H2C2_2	400..424	CDD:290200	12/23 (52%)
		C2H2 Zn finger	415..435	CDD:275368	3/19 (16%)
		zf-C2H2	441..463	CDD:278523	5/22 (23%)
		C2H2 Zn finger	443..463	CDD:275368	5/20 (25%)
Zbtb7a	XP_006240898.1	BTB	103..206	CDD:279045
		BTB	114..210	CDD:197585
		COG5048	455..>518	CDD:227381	30/64 (47%)
		C2H2 Zn finger	457..477	CDD:275368	8/19 (42%)
		zf-H2C2_2	472..494	CDD:290200	11/21 (52%)
		C2H2 Zn finger	485..505	CDD:275368	7/19 (37%)
		zf-H2C2_2	498..522	CDD:290200	15/25 (60%)
		C2H2 Zn finger	513..533	CDD:275368	8/21 (38%)
		zf-H2C2_2	525..550	CDD:290200	15/52 (29%)
		C2H2 Zn finger	541..559	CDD:275368	7/45 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000