DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kr-h1 and zbtb49

DIOPT Version :9

Sequence 1:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster
Sequence 2:	NP_001076468.1	Gene:	zbtb49 / 100009630	ZFINID:	ZDB-GENE-070209-170	Length:	524	Species:	Danio rerio

Alignment Length:	406	Identity:	119/406 - (29%)
Similarity:	176/406 - (43%)	Gaps:	74/406 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 SAQRIKTEPVGGFPASAAVVSQVRKPSASKPQFKCDQCGMTFGSKSAHT---SHTKSHSKNQDLS 223
            |.|.::..|..| ||.:.       |.|  ||.|          |:.:.   ::.:|..:.::..
Zfish   160 SRQYLQQSPAAG-PAPSG-------PGA--PQHK----------KTLYVKKFNYLRSQEEEEERC 204

  Fly   224 LNGASGAGVAAPVS--TAAIEL---------------NDAGLPVGIPKSPTIKPLANV------- 264
            ..|.:..|.|.|.|  |...:|               :|......:.::|..:| .|.
Zfish   205 AGGHAPCGPATPSSADTTPSDLCVTSDLCVTPDLCVTSDPAEAAELERTPEAEP-GNTGPQGQEQ 268

  Fly   265 -----AAGADPYQCNVCQKTFAVPARLIRHYRTHTGERPFECEFCHKLFSVKENLQVHRRIHTKE 324
                 ..|.:.|.|.||.|||..|:.|..|.|:||||:||:|..|.|.||...|||.|.|.|:.|
Zfish   269 RSGVSGGGGNKYCCEVCGKTFKHPSNLELHKRSHTGEKPFQCSVCGKAFSQAGNLQTHLRRHSGE 333

  Fly   325 RPYKCDVCGRAFEHSGKLHRHMRIHTGERPHKCSVCEKTFIQSGQLVIHMRTHTGEKPYKCPEPG 389
            :||.|::||::|..||.:.||:.||:|.|||.|.||.:.|.....|..|.:||..|:.:.|.:
Zfish   334 KPYICELCGKSFAASGDVQRHIIIHSGARPHLCDVCGRGFSNFSNLKEHKKTHRAEREFTCDQ-- 396

  Fly   390 CGKGFTCSKQLKVHSRTHTGEKPYHCDICFRDFGYNHVLKLHRVQHYGSKCYKCTICDETFKNKK 454
            |||.|...::|..|...|:|:|||.|..|.:.|..:..|:.|...|.|.:.|.|..|.::|....
Zfish   397 CGKSFNMQRKLLKHKSRHSGDKPYCCQTCGKCFAGSGDLQRHVRSHTGERPYVCDACGKSFSRTA 461

  Fly   455 EMEAHIKGHANEVPDDEAEAAAASAAASTSAGSSAGSPSLQG-VSSNSESSNHSPPSSPPATKKP 518
            .:..|              .:|....:||:|.....:|...| |..:||::    |...|.....
Zfish   462 VLRRH--------------RSAGVCVSSTAAPECVCAPQRPGEVCVSSEAA----PEPGPEELCS 508

  Fly   519 RQARQPRVSKTVAATL 534
            ..|...|..||:.:.|
Zfish   509 SGALWGRAMKTLQSDL 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	1/22 (5%)
		COG5048	<270..420	CDD:227381	68/149 (46%)
		zf-C2H2	271..293	CDD:278523	11/21 (52%)
		C2H2 Zn finger	273..293	CDD:275368	10/19 (53%)
		zf-H2C2_2	286..309	CDD:290200	12/22 (55%)
		C2H2 Zn finger	301..321	CDD:275368	10/19 (53%)
		zf-H2C2_2	313..338	CDD:290200	13/24 (54%)
		C2H2 Zn finger	329..349	CDD:275368	8/19 (42%)
		zf-H2C2_2	344..366	CDD:290200	12/21 (57%)
		C2H2 Zn finger	357..377	CDD:275368	6/19 (32%)
		zf-H2C2_2	370..396	CDD:290200	10/25 (40%)
		C2H2 Zn finger	385..407	CDD:275368	7/21 (33%)
		zf-H2C2_2	400..424	CDD:290200	10/23 (43%)
		C2H2 Zn finger	415..435	CDD:275368	5/19 (26%)
		zf-C2H2	441..463	CDD:278523	5/21 (24%)
		C2H2 Zn finger	443..463	CDD:275368	4/19 (21%)
zbtb49	NP_001076468.1	zf-H2C2_2	322..346	CDD:290200	12/23 (52%)
		C2H2 Zn finger	338..358	CDD:275368	8/19 (42%)
		C2H2 Zn finger	366..386	CDD:275368	6/19 (32%)
		zf-H2C2_2	378..402	CDD:290200	9/25 (36%)
		C2H2 Zn finger	394..414	CDD:275368	7/21 (33%)
		zf-H2C2_2	407..430	CDD:290200	9/22 (41%)
		C2H2 Zn finger	422..442	CDD:275368	5/19 (26%)
		zf-H2C2_2	434..459	CDD:290200	8/24 (33%)
		C2H2 Zn finger	450..467	CDD:275368	4/30 (13%)
		BTB	15..118	CDD:279045
		BTB	26..118	CDD:197585
		zf-C2H2	280..302	CDD:278523	11/21 (52%)
		C2H2 Zn finger	282..302	CDD:275368	10/19 (53%)
		COG5048	<292..466	CDD:227381	70/175 (40%)
		zf-H2C2_2	294..319	CDD:290200	13/24 (54%)
		C2H2 Zn finger	310..330	CDD:275368	10/19 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000