DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kr-h2 and npp-25

DIOPT Version :9

Sequence 1:	NP_001162894.1	Gene:	Kr-h2 / 33859	FlyBaseID:	FBgn0266449	Length:	276	Species:	Drosophila melanogaster
Sequence 2:	NP_499684.1	Gene:	npp-25 / 189617	WormBaseID:	WBGene00012555	Length:	271	Species:	Caenorhabditis elegans

Alignment Length:	272	Identity:	93/272 - (34%)
Similarity:	143/272 - (52%)	Gaps:	19/272 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PTDQPPRSEGAQTNSSERSSQQQEQPQQSQSQNVPAKLLQHFQTNRIDSALWALRLLVIFFTVSY 68
            |.|....|.||  .||..||.....|..:.|     .:.|:...|.::..|:|.|:|.:||.::|
Worm     8 PDDHQSSSTGA--GSSGSSSAPPPPPPPAYS-----SISQYVSANTMECVLFAARVLTVFFALNY 65

  Fly    69 VLPI--FTSQQSAFSKVMLANAAISALRLHQRLPA-FAFSREFLARLFAEDSCHYMMYSLIFFNI 130
            ::|.  .....||:.|:..|:||..|||||.|:.. ||.:.:|:.||..|||.||::||::|...
Worm    66 MIPFIGLVPAHSAYYKIFAASAATFALRLHTRIQGQFALNAQFIQRLIIEDSFHYLVYSVVFLMA 130

  Fly   131 RPSLLVLIPVLLYSVLHASSYSLKLLDLIGQNSWWGARFIISIVEF---QAANILKATAFCEIFI 192
            .|..:..:||.:|:.|||.::..|:|...|..|    ..|..:.:|   |..|.|...|..|||:
Worm   131 APVSMAALPVTIYAALHACTFMTKILRETGHTS----SIIPKLEQFTAHQTQNALGIIACSEIFL 191

  Fly   193 MPYAIVLAFMNHAGLMTPVIYYHYLVMRYSSRRNPYPRNAFAELRITFE--ALAARSPPAFAKII 255
            :|..:.|.|.....|:.|..||.:|.:||:|||||..|.|||::|.:.:  |:::..|...:.:|
Worm   192 VPLLVSLIFSGKGSLLLPFAYYRFLSLRYASRRNPSTRQAFAQMRGSLQNVAMSSSCPRPISSLI 256

  Fly   256 RGGIGFVNRLAP 267
            ...|.|::..||
Worm   257 YRAIDFISARAP 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kr-h2	NP_001162894.1	UPF0121	39..268	CDD:281636	82/237 (35%)
npp-25	NP_499684.1	UPF0121	40..269	CDD:281636	82/233 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159732
Domainoid	1	1.000	145	1.000	Domainoid score	I2833
eggNOG	1	0.900	-	-		E1_KOG4002
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10018
Inparanoid	1	1.050	149	1.000	Inparanoid score	I2979
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56186
OrthoDB	1	1.010	-	-		D1360050at2759
OrthoFinder	1	1.000	-	-		FOG0004962
OrthoInspector	1	1.000	-	-		oto18535
orthoMCL	1	0.900	-	-		OOG6_104324
Panther	1	1.100	-	-	LDO	PTHR12703
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2850
SonicParanoid	1	1.000	-	-		X5298
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800