Protein Alignment KCNK18 and sand

DIOPT Version :10

• Sequence 1: NP_862823.1
• Gene: KCNK18 / 338567
• HGNCID: 19439
• Length: 384
• Species: Homo sapiens
• Sequence 2: NP_610349.1
• Gene: sand / 35777
• FlyBaseID: FBgn0033257
• Length: 395
• Species: Drosophila melanogaster
• Alignment Length: 402
• Identity: 86/402 - (21%)
• Similarity: 162/402 - (40%)
• Gaps: 99/402 - (24%)

Human    13 CPEALGKLFPGLCFLCFLVTYALVGAVVFSAIEDGQVLVAADDGEFEKFLEE------------- 64
            |......:|..:..:..:..|.:.||.:|.:||         ..|:|:...|
  Fly    23 CRHFTAFMFSNVGIILLVTFYIIGGAFIFQSIE---------IFEYERLKSEKPHRFIARNFSGE 78

Human    65 -LCRILN-CSETV-----------VEDRKQDLQGHLQKVK---PQWFNRTTHWSFLSSLFFCCTV 113
             |.||.. .:|.:           |.|...|.|..:.|.:   |.    ...|||..:..:..||
  Fly    79 CLSRIWELTAENISFFDHHAYRRRVNDVLLDYQRAIVKKQLKGPD----VEQWSFSGAFLYSLTV 139

Human   114 FSTVGYGYIYPVTRLGKYLCMLYALFGIPLMFLVLTDTGDILATILSTSYNRFRKFPFFTRPLLS 178
            .:|:|||.|.|.:..||.:.:|||:.|:||..|.|::.||:||......|::.         .|.
  Fly   140 ITTIGYGNITPHSECGKLVTILYAIIGMPLFLLYLSNIGDVLAKSFKWIYSKV---------CLC 195

Human   179 KWCPKSLFKKKPDPKPADEAVPQIIISAEELPGPKLGTCPSRPSCSMELFERSHALEKQNTLQLP 243
            :.|| .:.|::            ||....::         .:.:.::::.:..:|....:.....
  Fly   196 RICP-GVAKRR------------IIRERRKM---------RQLARALQMHDMENARGSSSYTSTS 238

Human   244 PQAMERSNSCPELVLGRLSYSII--------SNLD-EVGQQVERLDIPLPIIALIVFAYISCAAA 299
            ......|:|.......|.|.|::        |::: |:....:.:.:|:.:...::..||...|.
  Fly   239 STTSSNSSSSEYTRSSRQSSSLVDIQYTESDSDIEREIRGSTDEITVPVTVCVFVMVGYILWGAL 303

Human   300 ILPFWETQLDFENAFYFCFVTLTTIGFGDTVLEHPN-------------FFLFFSIYIIVGMEIV 351
            :...|| ..::.:..|||.::|::|||||.|   |.             .|:..:||:::||.::
  Fly   304 LFGRWE-DWNYLDGSYFCLISLSSIGFGDLV---PGDRVITADRDKVEVSFILCAIYLLLGMAVI 364

Human   352 FIAFKLVQNRLI 363
            .:.|.|:|.:::
  Fly   365 AMCFNLMQEQVV 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNK18	NP_862823.1	Ion_trans_2	94..155	CDD:462301	23/60 (38%)
		Selectivity filter 1. /evidence=ECO:0000305|PubMed:36426390	116..121		3/4 (75%)
		Interaction with calcineurin. /evidence=ECO:0000250|UniProtKB:Q6VV64	200..205		2/4 (50%)
		Interaction with YWHAH. /evidence=ECO:0000250|UniProtKB:Q6VV64	249..254		2/4 (50%)
		Ion_trans_2	285..364	CDD:462301	24/92 (26%)
		Selectivity filter 2. /evidence=ECO:0000305|PubMed:36426390	323..328		3/4 (75%)
sand	NP_610349.1	Ion_trans_2	<127..183	CDD:462301	24/55 (44%)
		Ion_trans_2	292..376	CDD:462301	24/87 (28%)