Protein Alignment KCNK18 and twk-48

DIOPT Version :10

• Sequence 1: NP_862823.1
• Gene: KCNK18 / 338567
• HGNCID: 19439
• Length: 384
• Species: Homo sapiens
• Sequence 2: NP_001022681.1
• Gene: twk-48 / 3565640
• WormBaseID: WBGene00010784
• Length: 372
• Species: Caenorhabditis elegans
• Alignment Length: 375
• Identity: 97/375 - (25%)
• Similarity: 158/375 - (42%)
• Gaps: 85/375 - (22%)

Human    23 GLCFLCFLVTYALVGAVVFSAIEDGQVLVAADDGEFEKFLEELCRILNCSETVVE---------- 77
            |||.|  :|.|||:|||:|.|:|          |..|..::||  :.:..|..|:
 Worm    29 GLCAL--VVGYALLGAVIFKAVE----------GPHEAEIQEL--VKSAREKAVDVVWNATFRVN 79

Human    78 --DRKQDLQGHLQKVK---------------PQWFNRTTHWSFLSSLFFCCTVFSTVGYGYIYPV 125
              |.||..:..|.:||               .:.:.:...|:|..:..:..||.:|:|||.....
 Worm    80 RLDSKQWKKTVLDEVKRFKTVCMLSIRKGYDGKEYGKQAQWTFTGAFLYSLTVITTIGYGNTAAK 144

Human   126 TRLGKYLCMLYALFGIPLMFLVLTDTGDILATILSTSYNRFRKFPFFTRPLLSKWCPKSLFKKKP 190
            |.:||.|.||||:.|||||.|.||:.||::|.|....|.:..:..|  |.:|  |..|   :|..
 Worm   145 TYIGKTLTMLYAIIGIPLMLLFLTNIGDVMAKIFRFLYAQSIRLKF--RLIL--WHKK---RKAA 202

Human   191 DPKPADEAVPQIIISAEELPGPKLGTCPSRPSCSMELFERSHALEKQNTLQLPPQAMERSNSCPE 255
            ..:.|:..|.::                          .|.|.::..:::.  ...:.......:
 Worm   203 KIRRANSLVSRL--------------------------TRGHRVKADSSVD--SFGLGAGADVED 239

Human   256 LVLGRLSYSIISNLDEVGQQVERLDIPLPIIALIVFAYISCAAAILPFWETQLDFENAFYFCFVT 320
            |:..|:....:...:....|:|.:.:|:.::...:..|:.....|...|| ...|..:|||||::
 Worm   240 LLTARVEMEQLEVRETAAAQLESMTVPISLVVFTMLGYLGVGTTIFKVWE-GWTFLESFYFCFIS 303

Human   321 LTTIGFGD--------TVLEHPNFFLFFSIYIIVGMEIVFIAFKLVQNRL 362
            ||||||||        ...|.....:..|||::.||.::.:.|.|.|..:
 Worm   304 LTTIGFGDKFPSTSVSNTDEAQEKLVITSIYLLFGMALLAMCFNLAQEEV 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNK18	NP_862823.1	Ion_trans_2	94..155	CDD:462301	26/60 (43%)
		Selectivity filter 1. /evidence=ECO:0000305|PubMed:36426390	116..121		3/4 (75%)
		Interaction with calcineurin. /evidence=ECO:0000250|UniProtKB:Q6VV64	200..205		0/4 (0%)
		Interaction with YWHAH. /evidence=ECO:0000250|UniProtKB:Q6VV64	249..254		0/4 (0%)
		Ion_trans_2	285..364	CDD:462301	27/86 (31%)
		Selectivity filter 2. /evidence=ECO:0000305|PubMed:36426390	323..328		4/4 (100%)
twk-48	NP_001022681.1	Ion_trans_2	<120..176	CDD:462301	26/55 (47%)
		Ion_trans_2	272..355	CDD:462301	27/83 (33%)