Protein Alignment KCNK18 and kcnk18

DIOPT Version :10

• Sequence 1: NP_862823.1
• Gene: KCNK18 / 338567
• HGNCID: 19439
• Length: 384
• Species: Homo sapiens
• Sequence 2: XP_031761959.1
• Gene: kcnk18 / 100486306
• XenbaseID: XB-GENE-6257492
• Length: 429
• Species: Xenopus tropicalis
• Alignment Length: 431
• Identity: 165/431 - (38%)
• Similarity: 225/431 - (52%)
• Gaps: 92/431 - (21%)

Human     7 PQARRC---CPEALGKLFPGLCFLCFLVTYALVGAVVFSAIEDGQVLVAADDGEFEKFLEELCRI 68
            ||..:|   |.:|....||.:|.:|.||.|:::||::|..||..:   ..:..:||:|||:|..|
 Frog    28 PQRGKCSWKCLQAFWISFPHVCLVCSLVLYSILGALMFWFIEGSR---EKEISQFEEFLEKLWMI 89

Human    69 LNCS----------------------ETVVEDRKQDLQGHLQKVKPQWFNRTTHWSFLSSLFFCC 111
            :..|                      |.::.|.:.:   .|||.:.|       |||.|||||||
 Frog    90 VQNSSIDNATISDNGSAPEIFKELAREAIITDLQVE---WLQKPEEQ-------WSFKSSLFFCC 144

Human   112 TVFSTVGYGYIYPVTRLGKYLCMLYALFGIPLMFLVLTDTGDILATILSTSYNRFRKFPFFTRPL 176
            |||:|||||:|.|||..||..||:||..|||||.|:|.|.|||||.:||.:|.         |.:
 Frog   145 TVFTTVGYGHICPVTMYGKLACMVYATLGIPLMLLLLADLGDILARLLSRTYK---------RAV 200

Human   177 LSKWCPKSLFKKKPDPKPADEAVPQIIISA--EELPGPK--LGTCPSRPSC-------------- 223
            |:  |.|...|.||           |.:|:  :|..|..  |.|..||.|.
 Frog   201 LA--CNKLCHKPKP-----------IKLSSLHKEHSGKSSLLKTMDSRVSMKEPLNITEVIKTQA 252

Human   224 ----------SMELFERSHALEKQNTLQLPPQAMERSNSCPELVLGRLSYSIISNLDEVGQQVER 278
                      ::::||.....|.|..|.|.....::|.|||:|.|...|.|.:.|.|::|::::.
 Frog   253 SVKRKYLQMRNIDIFELIIVKENQKVLPLKSSLQQKSFSCPDLDLWPPSDSAMQNFDKIGEELDH 317

Human   279 LDIPLPIIALIVFAYISCAAAILPFWETQLDFENAFYFCFVTLTTIGFGDTVLEHPNFFLFFSIY 343
            ||:|:.:|.|::.|||.|.|.|||.||......:||||||||||||||||.:.:|||:||..|.|
 Frog   318 LDVPIVLIVLVMVAYIMCGACILPLWEDDWTTIDAFYFCFVTLTTIGFGDIIPKHPNYFLLLSAY 382

Human   344 IIVGMEIVFIAFKLVQNRLIDIYKNVMLFFAKGKFYHLVKK 384
            .:|||.||.:||||.||||:..||..:|..:.|.    :||
 Frog   383 TVVGMVIVCMAFKLGQNRLVSFYKQCILCISGGN----IKK 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNK18	NP_862823.1	Ion_trans_2	94..155	CDD:462301	38/60 (63%)
		Selectivity filter 1. /evidence=ECO:0000305|PubMed:36426390	116..121		4/4 (100%)
		Interaction with calcineurin. /evidence=ECO:0000250|UniProtKB:Q6VV64	200..205		1/4 (25%)
		Interaction with YWHAH. /evidence=ECO:0000250|UniProtKB:Q6VV64	249..254		2/4 (50%)
		Ion_trans_2	285..364	CDD:462301	48/78 (62%)
		Selectivity filter 2. /evidence=ECO:0000305|PubMed:36426390	323..328		4/4 (100%)
kcnk18	XP_031761959.1	Ion_trans_2	<134..>175	CDD:462301	29/40 (73%)
		Ion_trans_2	322..402	CDD:462301	47/79 (59%)