DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9150 and HSD11B1L

DIOPT Version :9

Sequence 1:	NP_608991.2	Gene:	CG9150 / 33856	FlyBaseID:	FBgn0031775	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_001254797.1	Gene:	HSD11B1L / 374875	HGNCID:	30419	Length:	333	Species:	Homo sapiens

Alignment Length:	235	Identity:	54/235 - (22%)
Similarity:	101/235 - (42%)	Gaps:	27/235 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QNKLAVVTGASGGIGAACARAMIGAGLRVVGLARREAKLKELRESLPRELQANFIPR----RCDV 65
            |....::|||:.|:|...|......|..:|..|..||.|:::..:. |:|.|   |:    ..|:
Human    75 QGARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNC-RKLGA---PKVFYIAADM 135

  Fly    66 SKEDQVQSSFDWIERELEGADVLLNN--AGITRETELVTPSNTQKLKEVIDTNVMGVIWCTREAF 128
            :..:..:|...:...:|.|.|.|:.|  .|....|...:|..|:.|.:|   |.:..:..|..|.
Human   136 ASPEAPESVVQFALDKLGGLDYLVLNHIGGAPAGTRARSPQATRWLMQV---NFVSYVQLTSRAL 197

  Fly   129 NNMKRRGGEGHVLIINSIAGHQVLNFIDVLPSFNI-YPATKFAITAITETYRQEFQLHSNKIRVT 192
            .::  ...:|.:::::|:.|.       |..||:. |.|.|||:.....:.|:|..:....:.:|
Human   198 PSL--TDSKGSLVVVSSLLGR-------VPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVAIT 253

  Fly   193 GICPGAVNTNIFPEEIHFYVKDMARLEPANIADAVMYALR 232
             :|...:.......|.   |:.:.|::.|....|.:..:|
Human   254 -MCVLGLRDRASAAEA---VRGVTRVKAAPGPKAALAVIR 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9150	NP_608991.2	YdfG	1..251	CDD:226674	54/235 (23%)
CG9150	NP_608991.2	NADB_Rossmann	1..247	CDD:304358	54/235 (23%)
HSD11B1L	NP_001254797.1	GVQW	3..>26	CDD:290611
		NADB_Rossmann	74..302	CDD:304358	54/235 (23%)
		PRK08251	78..302	CDD:181324	53/232 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1205
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810