DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fbw5 and UFO1

DIOPT Version :9

Sequence 1:	NP_608989.1	Gene:	Fbw5 / 33854	FlyBaseID:	FBgn0031773	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_013622.1	Gene:	UFO1 / 854886	SGDID:	S000004553	Length:	668	Species:	Saccharomyces cerevisiae

Alignment Length:	716	Identity:	118/716 - (16%)
Similarity:	222/716 - (31%)	Gaps:	274/716 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWRHKFQE-----HFKASPSIPLKPGSES 98
            ||...|:.||..|...||.........:.::..|:.||::.|:.     ||      |....|..
Yeast    11 LPPEILINIFSHLDEKDLFTLQELSTHFRNLIHDEELWKNLFKSRVHTTHF------PTFSQSSK 69

  Fly    99 WRAEYKRLSMHIPFVQAQRLEPTVENNHGHTHQVLHVSFAHNGEMFATCSKDGYVII----WNAQ 159
            :..||                  :|...|..|      :.||..:     :..|.||    |:
Yeast    70 FSVEY------------------IERTRGLHH------WQHNKAI-----RTKYTIIPTRNWD-- 103

  Fly   160 HPCSEKYAHNMKQFSWKYSQYSQFNQSDTLLLVSGVH-------------FGSPQSTSGEIAVFY 211
            .|..|:..       :.|.:.:.:|.....:|....|             ..:||..|
Yeast   104 QPSIERIV-------FDYPRVAAYNDGTITILQLQNHKRQKKFKKLIYIPCTTPQGCS------- 154

  Fly   212 LGATESHLRCRVVNRPYD--IFGTWFSDQ-YLISGDLHWLAHLVSTSVLWLNKANQEIDSEHVPI 273
              ..:.::...|..| :|  :||...|:: ||                              .|:
Yeast   155 --TMDFNINAAVFGR-FDGRVFGKLLSNKSYL------------------------------TPV 186

  Fly   274 MSQLYKFYNRNASSVRAIMVARCPWLDESNDPLATTADQESHSSVLSPPTGDQGSTSQASGNPVS 338
            |    :|..|:::.|.||..:. .| |.|.:                    |...:...:|..:.
Yeast   187 M----EFTGRHSAGVTAICNSE-SW-DTSRE--------------------DWSVSGSENGEIIW 225

  Fly   339 HAASILRTRSSTPEENYLPDISERRSR-----ARLGDATIHYLDEYRTAVATTNESNDDDDEEYD 398
            ..            ||.|..:.:..:|     |...|.|:...||....:        ...:|..
Yeast   226 WC------------ENKLVKMWKVSNRVIWKLAFFKDWTLIMDDEKLYII--------HQMQELH 270

  Fly   399 SMDVQEEYDEMENSIPKYLIFSTGSTTFTPHQI------------GFKRIRNVFFPKKLDPGPSL 451
            |:|:.::.||....: ::.....||.|.....:            .|..:|.:..|:::
Yeast   271 SIDIPKDLDEQPMRV-RFFKMDFGSMTLVLADLNNVYTISVNPNGNFGNLRKLEMPEQI------ 328

  Fly   452 KERIAAKRAAEQQQQQTPRTDPDWWDYESVKDRFDKVDKVIDLHGHIIGMALSPDHRYLYVNTRP 516
                    .|.:..::|.:.:.:|        :|...|      |..|.:..:.:..|: :|.|.
Yeast   329 --------CAVEIDEKTSQREQNW--------QFAGDD------GCYISLLTTQNTLYI-INIRD 370

  Fly   517 WPKN--------------YV--ITNPLEPPPIAQEIDIHVIDLMTLKRVGNMLRAHKAYTPSAEC 565
            ...:              ||  :||.:  ..:|....:.:::.||.:.:..:|:..|
Yeast   371 LSSSGLKVQCKISFDEQVYVSQVTNLI--VVVALPNVLQILNAMTGELIKTVLKTEK-------- 425

  Fly   566 FFIFLDVCEEYVASGAEDQHAYL-----------------------WD-------RYY--GISLA 598
            |..||.|.::.:..|:.:...||                       |:       :||  ...|.
Yeast   426 FPEFLKVSQDKIIMGSGNVLNYLKFVSSDSKKHHHSTKGKNTVSNKWNETLNTELQYYDEDEDLR 490

  Fly   599 KFKHSDVVNSVAFNPRDSEMLVTTSDDYTIKV-----------WRSRAKAKEFNIPINVSESFEL 652
            :.:.|::...:.....|.|:...|.::..|::           .|::|:|.|   |:...|..:|
Yeast   491 RKRQSEISRLIDAYGGDLELSGDTDEENDIQLRIALLESQEAQARNQAEAGE---PVGDDEDEQL 552

  Fly   653 K 653
            :
Yeast   553 R 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbw5	NP_608989.1	F-box-like	36..82	CDD:289689	12/42 (29%)
		WD40	126..157	CDD:197651	7/34 (21%)
		WD40 repeat	132..176	CDD:293791	8/47 (17%)
		WD40	<538..>644	CDD:225201	24/148 (16%)
		WD40	<553..>637	CDD:295369	20/126 (16%)
		WD40 repeat	566..600	CDD:293791	11/65 (17%)
UFO1	NP_013622.1	F-box-like	8..52	CDD:403981	11/40 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5529
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030