Protein Alignment Fbw5 and fbxw5

DIOPT Version :10

• Sequence 1: NP_608989.1
• Gene: Fbw5 / 33854
• FlyBaseID: FBgn0031773
• Length: 656
• Species: Drosophila melanogaster
• Sequence 2: XP_031746243.1
• Gene: fbxw5 / 493431
• XenbaseID: XB-GENE-1017271
• Length: 560
• Species: Xenopus tropicalis
• Alignment Length: 622
• Identity: 248/622 - (39%)
• Similarity: 353/622 - (56%)
• Gaps: 91/622 - (14%)

  Fly    38 ALPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWRHKFQEHFKASPSIPL--KPGSESWR 100
            :||:..|..||....:| :..|...|.||:.:::||.||:..|..||:....|..  |||:|||.
 Frog     9 SLPDSILYQIFRGRCLP-ISSAGLVCRRWYRVSRDDFLWKELFYRHFRVHRDILRIHKPGAESWY 72

  Fly   101 AEYKRLSMHIPFVQAQRLEPTVENNHGHTHQVLHVSFAHNGEMFATCSKDGYVIIWNAQHPCSEK 165
            .|::|:...:|.|:||||..       |..||||:||:|:|::||:||||..:.:|.:..|.|.:
 Frog    73 EEFQRVCDAVPRVEAQRLRE-------HGDQVLHISFSHSGDLFASCSKDCTIKVWASAPPISVR 130

  Fly   166 YAHNMKQFSWKYSQYSQFNQSDTLLLVSGVHFGSPQSTSGEIAVFYLGATESHLRCRVVNRPYDI 230
            ::.:||...|.|:|:||||..|:|||||||..|...|::||||||.|  ....|..||.|:|||:
 Frog   131 HSADMKPHHWSYTQFSQFNSDDSLLLVSGVFVGPHNSSAGEIAVFSL--DNFLLLSRVRNKPYDV 193

  Fly   231 FGTWFSDQYLISGDLHWLAHLVSTSVLWLNKANQEIDSEHVPIMSQLYKFYNRNASSVRAIMVAR 295
            ||.|.|:.:||||:||.:..:.|.||||||.|.|:::||:|.::.:|:|..|.|||::|.:|||.
 Frog   194 FGCWLSNSHLISGNLHRMGRVTSCSVLWLNNAFQDVESENVNVVKRLFKIQNLNASTIRMVMVAN 258

  Fly   296 CPWLDESNDPLATTADQESHSSVLSPPTGDQGSTSQASGNPVSHAASILRTRSSTPEENYLPDIS 360
            .|      |.|....||....:...||.                        .:..||.   |..
 Frog   259 SP------DLLVEVTDQSEEGTKSPPPP------------------------QAEEEEG---DAE 290

  Fly   361 ERRSRARLGDATIHYLDEYRTAVATTNESNDD---DDEEYDSMDVQEEYDEMENSIP-------- 414
            |..:...:|:......:|.:..:|...|....   .:.:::: .|.:.|.:.....|
 Frog   291 EEDAEREIGEENERLEEELQIFLANGEEGLPRPILSENQFET-KVAQLYAQYRTKRPDGGPTATE 354

  Fly   415 -----KYLIFSTGSTTFTPHQIGFKRIRNVFFPKKL-DPGPSLKERIAAKRAAEQQQQQTPRTDP 473
                 |||||:|||.|:.|||||.|::    .|.:: ..||.|.|            ::.|
 Frog   355 GDPGKKYLIFTTGSLTYAPHQIGIKQL----LPHQMTTAGPVLGE------------ERGP---- 399

  Fly   474 DWWDYESVKDRFDKVDKVIDLHGHIIGMALSPDHRYLYVNTRPWPKNYVITNPLEPPPIAQEIDI 538
                    .:.||.:|.||::|||||||.|||||||||||:||||.:.|:.:|::|||||:||::
 Frog   400 --------NEFFDALDHVINIHGHIIGMGLSPDHRYLYVNSRPWPHDCVVADPMDPPPIAEEIEL 456

  Fly   539 HVIDLMTLKRVGNMLRAHKAYTPSAECFFIFLDVCEEYVASGAEDQHAYLWDRYYGISLAKFKHS 603
            .:.||.:|:.....||||:||||:.|||||||||..::|||||||...|:|||:|...|||..|.
 Frog   457 RLFDLRSLREAATPLRAHRAYTPNNECFFIFLDVSTDFVASGAEDHCGYVWDRHYSACLAKLPHD 521

  Fly   604 DVVNSVAFNPRDSEMLVTTSDDYTIKVWRSRAKAKEF 640
            ||||||||:|.:.|:|::.|||:||||||||...:.:
 Frog   522 DVVNSVAFSPANQELLLSASDDFTIKVWRSRRSLRHY 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fbw5	NP_608989.1	F-box-like	36..80	CDD:463757	14/41 (34%)
		WD40	126..157	CDD:197651	15/30 (50%)
		WD40 repeat	132..176	CDD:293791	18/43 (42%)
		WD40 repeat	566..600	CDD:293791	21/33 (64%)
		WD40	<575..632	CDD:441893	34/56 (61%)
fbxw5	XP_031746243.1	F-box_SF	8..51	CDD:459239	14/42 (33%)
		WD40	<77..206	CDD:441893	64/137 (47%)
		WD40	88..121	CDD:197651	18/39 (46%)
		WD40	<456..550	CDD:441893	54/93 (58%)
		WD40 repeat	483..509	CDD:293791	17/25 (68%)
		WD40 repeat	524..549	CDD:293791	15/24 (63%)