DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fbw5 and fbxw5

DIOPT Version :9

Sequence 1:	NP_608989.1	Gene:	Fbw5 / 33854	FlyBaseID:	FBgn0031773	Length:	656	Species:	Drosophila melanogaster
Sequence 2:	NP_998484.1	Gene:	fbxw5 / 406611	ZFINID:	ZDB-GENE-040426-2571	Length:	597	Species:	Danio rerio

Alignment Length:	644	Identity:	262/644 - (40%)
Similarity:	362/644 - (56%)	Gaps:	99/644 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWRHKFQEHFKASPSIPLKPGSESWRAEY 103
            ||:..:|.||..|....:|.|...|.:|.::::|:.||:..|..:::...::|..|.:.||..|:
Zfish     7 LPDSLVLEIFLHLPHKAVLSAGLTCHQWFAVSRDEFLWKELFYSYYRIPRTVPRHPAAVSWYREF 71

  Fly   104 KRLSMHIPFVQAQRLEPTVENNHGHTHQVLHVSFAHNGEMFATCSKDGYVIIWNAQ--------- 159
            |||...||.|:.|.|:.       |..||||::|:|.|..|::||||..|.:|:.:
Zfish    72 KRLYDCIPCVEVQTLKE-------HHDQVLHLAFSHRGHRFSSCSKDCTVKLWDTEQSDGTISLV 129

  Fly   160 HPCSEKYAHNMKQFSWKYSQYSQFNQSDTLLLVSGVHFGSPQSTSGEIAVFYLGATESHLRCRVV 224
            |.||      |:|::|.|:|:||||..|||||||||:.|...|::||||||.|  ....|..||.
Zfish   130 HSCS------MRQYNWGYTQFSQFNADDTLLLVSGVYLGPHHSSAGEIAVFSL--DNYTLLSRVR 186

  Fly   225 NRPYDIFGTWFSDQYLISGDLHWLAHLVSTSVLWLNKANQEIDSEHVPIMSQLYKFYNRNASSVR 289
            |:|||:||.|.::.:||||:|||:.::.|.||||||.|.|.|:||:|.::.:|:|..|.|||::|
Zfish   187 NKPYDVFGCWLNETHLISGNLHWIGNMTSCSVLWLNNAFQGIESENVNVVKRLFKIQNINASTIR 251

  Fly   290 AIMVARCPWLDESNDPLATTADQESHSSVLSPPTGDQGSTSQASGNPVSHAASILRTRSSTPEEN 354
            .:|||.|...| |.|.|.....|...:....|...|.|:|..                    ||.
Zfish   252 TVMVAHCRRHD-SPDLLLDYEAQAQRTQQHQPLFFDLGNTDS--------------------EEE 295

  Fly   355 YLPDISERRSRARLG-------DATIHYL-----------DEYRTAVATTNESNDDDDEEYDSMD 401
            ...|..|.|...||.       .:.:|::           .|..|.||....|......|.:.:.
Zfish   296 GEDDAEEERGEKRLAAHLPSLKPSGLHHVLHGCQSIATRERELETKVARLMGSRRTKAPELNLVS 360

  Fly   402 VQE--EYDEMENSIPKYLIFSTGSTTFTPHQIGFKRIRNVFFPKKLDP-GPSLKERIAAKRAAEQ 463
            ...  |.::|     .||:|:|||.|::|||||.|||    .|.::.. ||.|.|    :|::|
Zfish   361 PSNVGEGEDM-----TYLLFTTGSLTYSPHQIGIKRI----MPDQMTTCGPVLGE----ERSSE- 411

  Fly   464 QQQQTPRTDPDWWDYESVKDRFDKVDKVIDLHGHIIGMALSPDHRYLYVNTRPWPKNYVITNPLE 528
                               :.||.:|.|||:|||||||.|||||||||||:|.||...||::|:.
Zfish   412 -------------------EFFDSLDHVIDIHGHIIGMGLSPDHRYLYVNSRAWPAGCVISDPMS 457

  Fly   529 PPPIAQEIDIHVIDLMTLKRVGNMLRAHKAYTPSAECFFIFLDVCEEYVASGAEDQHAYLWDRYY 593
            |||||:|||:|||||.:|:.....||||:|:||:.|||||||||..::|||||||:|.|:|||:|
Zfish   458 PPPIAEEIDLHVIDLKSLREERRSLRAHRAFTPNDECFFIFLDVSRDFVASGAEDKHGYIWDRHY 522

  Fly   594 GISLAKFKHSDVVNSVAFNPRDSEMLVTTSDDYTIKVWRSRAKAKEFNIPINVSESFEL 652
            .|.||:.:|.||||||||:|.|.|:|::.|||.|||||||....:....|...|.:.:|
Zfish   523 NICLARLQHDDVVNSVAFSPADQELLLSASDDSTIKVWRSPRMVRLSQAPRPPSRAHKL 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbw5	NP_608989.1	F-box-like	36..82	CDD:289689	14/42 (33%)
		WD40	126..157	CDD:197651	14/30 (47%)
		WD40 repeat	132..176	CDD:293791	18/52 (35%)
		WD40	<538..>644	CDD:225201	61/105 (58%)
		WD40	<553..>637	CDD:295369	55/83 (66%)
		WD40 repeat	566..600	CDD:293791	23/33 (70%)
fbxw5	NP_998484.1	F-box-like	7..50	CDD:289689	14/42 (33%)
		WD40	<60..>158	CDD:225201	45/110 (41%)
		WD40	83..118	CDD:197651	16/41 (39%)
		WD40 repeat	94..130	CDD:293791	12/35 (34%)
		WD40 repeat	132..186	CDD:293791	31/61 (51%)
		WD40	<467..>560	CDD:225201	57/92 (62%)
		WD40	<477..>560	CDD:295369	51/82 (62%)
		WD40 repeat	494..530	CDD:293791	24/35 (69%)
		WD40 repeat	535..560	CDD:293791	16/24 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594097
Domainoid	1	1.000	319	1.000	Domainoid score	I1225
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H8496
Inparanoid	1	1.050	443	1.000	Inparanoid score	I1623
OMA	1	1.010	-	-		QHG49757
OrthoDB	1	1.010	-	-		D335990at33208
OrthoFinder	1	1.000	-	-		FOG0007376
OrthoInspector	1	1.000	-	-		oto41603
orthoMCL	1	0.900	-	-		OOG6_109886
Panther	1	1.100	-	-	LDO	PTHR20995
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5529
SonicParanoid	1	1.000	-	-		X6267
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.940