DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fbw5 and Fbxw5

DIOPT Version :9

Sequence 1:NP_608989.1 Gene:Fbw5 / 33854 FlyBaseID:FBgn0031773 Length:656 Species:Drosophila melanogaster
Sequence 2:NP_038936.1 Gene:Fbxw5 / 30839 MGIID:1354731 Length:573 Species:Mus musculus


Alignment Length:612 Identity:254/612 - (41%)
Similarity:353/612 - (57%) Gaps:73/612 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 DEGSSGQDLFGWWALPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWRHKFQEHFKASPS 89
            |||       |...||:..:..||..|...|:|.|...|.:|.::::|:.||:.:|..:::.:..
Mouse     2 DEG-------GLPLLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWKEQFYRYYQVARD 59

  Fly    90 IPLKPGSESWRAEYKRLSMHIPFVQAQRLEPTVENNHGHTHQVLHVSFAHNGEMFATCSKDGYVI 154
            :|..|.:.||..|::||...:|.|:.|.|:.       ||.||||:||:|:|..||:||||..|.
Mouse    60 VPRHPAATSWYEEFRRLYDMVPCVEVQTLKE-------HTDQVLHLSFSHSGYQFASCSKDCTVK 117

  Fly   155 IWNAQHPCSEKYAHNMKQFSWKYSQYSQFNQSDTLLLVSGVHFGSPQSTSGEIAVFYLGATESHL 219
            |||.....|..::.:|:.::|.|:|:|||||.|:|||.|||..|...|:||||||..|.:..  |
Mouse   118 IWNNDLTISLLHSADMRPYNWSYTQFSQFNQDDSLLLASGVFLGPHNSSSGEIAVISLDSFA--L 180

  Fly   220 RCRVVNRPYDIFGTWFSDQYLISGDLHWLAHLVSTSVLWLNKANQEIDSEHVPIMSQLYKFYNRN 284
            ..||.|:|||:||.|.::..||||:||.:..:.|.||||||.|.|:::||:|.::.:|:|..|.|
Mouse   181 LSRVRNKPYDVFGCWLTETSLISGNLHRIGDITSCSVLWLNNAFQDVESENVNVVKRLFKIQNLN 245

  Fly   285 ASSVRAIMVARCPWLDESNDPLATTADQESHSSVLSPPTGDQGSTSQASGNPVSHAASILRTRSS 349
            ||::|.:|||.|...| |.|.|...:||......:....||   |.:.:.:|..|      |..|
Mouse   246 ASTIRTVMVADCSRFD-SPDLLLDASDQAGLPCRVFDLGGD---TEEEATDPGLH------TSGS 300

  Fly   350 TPEENYLPDI--SERRSRARLGDATIHYLDEYRTAVATTNESNDDDDEEYDSMDVQEEYDEMENS 412
            ...:..|..:  |......:|.|..:      .|.||...........|.:..|.:.        
Mouse   301 DHVKKGLRRVFDSVLDGHGQLSDCAL------ETKVAELLAQGHTKPPECNDADTRN-------- 351

  Fly   413 IPKYLIFSTGSTTFTPHQIGFKRIRNVFFPKKL-DPGPSLKERIAAKRAAEQQQQQTPRTDPDWW 476
              |||||:||..|::|||||.|:|    .|.:: ..||.|.|    .|.::.             
Mouse   352 --KYLIFTTGCLTYSPHQIGIKQI----LPHQMTTAGPVLGE----GRGSDA------------- 393

  Fly   477 DYESVKDRFDKVDKVIDLHGHIIGMALSPDHRYLYVNTRPWPKNYVITNPLEPPPIAQEIDIHVI 541
                   .||.:|.|||:|||||||.||||:||||||:|.||...|:.:|::|||||:|||:.|.
Mouse   394 -------FFDALDHVIDVHGHIIGMGLSPDNRYLYVNSRAWPPGSVVADPMQPPPIAEEIDLLVF 451

  Fly   542 DLMTLKRVGNMLRAHKAYTPSAECFFIFLDVCEEYVASGAEDQHAYLWDRYYGISLAKFKHSDVV 606
            ||.|::.|...||||:||||:.|||||||||..::|||||||:|.|:|||:|.|.|||.:|.|||
Mouse   452 DLKTMREVKRALRAHRAYTPNDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLAKLRHEDVV 516

  Fly   607 NSVAFNPRDSEMLVTTSDDYTIKVWRS 633
            |||||:|::.|:|:|.|||.|||.|||
Mouse   517 NSVAFSPQEQELLLTASDDATIKAWRS 543

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fbw5NP_608989.1 F-box-like 36..82 CDD:289689 14/45 (31%)
WD40 126..157 CDD:197651 18/30 (60%)
WD40 repeat 132..176 CDD:293791 19/43 (44%)
WD40 <538..>644 CDD:225201 61/96 (64%)
WD40 <553..>637 CDD:295369 56/81 (69%)
WD40 repeat 566..600 CDD:293791 23/33 (70%)
Fbxw5NP_038936.1 F-box-like 6..52 CDD:289689 14/45 (31%)
WD40 <62..>194 CDD:225201 64/140 (46%)
WD40 <65..>120 CDD:295369 27/61 (44%)
WD 1 90..129 21/45 (47%)
D-box 308..316 1/7 (14%)
WD40 <448..>541 CDD:225201 58/92 (63%)
WD40 <450..>541 CDD:295369 58/90 (64%)
WD 2 470..509 26/38 (68%)
WD40 repeat 475..501 CDD:293791 18/25 (72%)
WD 3 511..551 22/33 (67%)
WD40 repeat 516..541 CDD:293791 16/24 (67%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167848597
Domainoid 1 1.000 298 1.000 Domainoid score I1455
eggNOG 1 0.900 - - E1_28KZW
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H8496
Inparanoid 1 1.050 440 1.000 Inparanoid score I1655
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49757
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0007376
OrthoInspector 1 1.000 - - oto93537
orthoMCL 1 0.900 - - OOG6_109886
Panther 1 1.100 - - LDO PTHR20995
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5529
SonicParanoid 1 1.000 - - X6267
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.790

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