Protein Alignment Fbw5 and pof10

DIOPT Version :9

• Sequence 1: NP_608989.1
• Gene: Fbw5 / 33854
• FlyBaseID: FBgn0031773
• Length: 656
• Species: Drosophila melanogaster
• Sequence 2: NP_596201.1
• Gene: pof10 / 2539767
• PomBaseID: SPBC1703.06
• Length: 662
• Species: Schizosaccharomyces pombe
• Alignment Length: 584
• Identity: 120/584 - (20%)
• Similarity: 186/584 - (31%)
• Gaps: 191/584 - (32%)

  Fly    39 LPEPALLMIFERLSVPDLLRASRCCVRWHSIAKDDLLWRHKFQEHFKASPSIPLKP-GSESWRAE 102
            ||:..|::||..|....||.|...|..|..:..|||.||..|..||....|....| |:.:||.|
pombe    34 LPKEILIIIFSFLDPRSLLSAQCTCKYWKKLLSDDLSWRTAFFHHFAGDQSQIFSPLGNGTWRQE 98

  Fly   103 YKRLSMHIPFVQAQRLEPTV----ENNHGHTHQ-------------------------------- 131
            |             .|..|:    |...|.|.|
pombe    99 Y-------------LLRSTITRAYEKGKGQTVQYDCRVGQLTNLYYDFSSGRLYSGNWLTGTISV 150

  Fly   132 -----------VLHV----SFAH-------NGEMFATCSKDGY--VIIWNAQHPCSEKYAHNMKQ 172
                       :||.    ||.|       ..::|.....||.  ||:.:.|.....|:
pombe   151 SDPTTGKVERSLLHASTDGSFTHGLSTMTLGKQIFGFGFMDGRVGVILMSRQAETPRKF------ 209

  Fly   173 FSWKYSQYSQFNQSDTLLLVSGVHFGSPQSTSGEIAVFYLGATESHLRCRVVNRPYDIFGTWFSD 237
                  :|...:.:|::..:..:....|  .:|||.: ..|:.:..:.|..|.....:....|..
pombe   210 ------RYCLDSHADSVTCIDALTGDLP--PTGEIGM-VTGSDDGSVHCWDVKTGVSLQSFQFRS 265

  Fly   238 QYLISGDLHWLAHLVSTSVLWLNKANQEIDSEHVPIMSQLYKF--YNRNASSVRAIMVA--RCPW 298
            ..::|     |.......:|.::..|.|::|      .|||..  |.|:..:.:.|:::  :|..
pombe   266 SQILS-----LCFRPKYKMLLVDTFNYELNS------YQLYLIPGYARSRKNEQPILLSSRKCVL 319

  Fly   299 LDESNDPLATTADQESHSSVLS--------------------PPTGDQGSTSQASGNPVSHAASI 343
            .||...|...|||..:..:.||                    ...|.|.|:...:|.|.|.:
pombe   320 TDEEEPPCLMTADCCAGVAFLSRGAPKNCICRVSFKEFLEKNDNVGVQTSSIPLNGKPTSIS--- 381

  Fly   344 LRTR-----SSTP----------EENYLPDI----SERRSRARLGDATIH--------YLDEYRT 381
            |.|.     .|||          :||.|..:    :|..::|.|...|.:        ||:|...
pombe   382 LDTNDRVLSKSTPGRGARLLAVGDENGLVYVVNTRTEDPNKAILRTITAYSNFPITDIYLNEVAM 446

  Fly   382 AVATTNESNDDDDEEYDSMDVQEEYDEMENSIPKYLIFSTGSTTFTPHQIGFKRIRNVFFPKKLD 446
            .|.:.:        .|..:     ||.:..:..|.:..:..:....|       |..:.    ||
pombe   447 VVGSAS--------GYCGV-----YDTVTGNFLKKIASARNAARREP-------INCIL----LD 487

  Fly   447 PGP-SLKERIAAKRAAEQQQQQTPRTDPDWWDYESVKDRFDKVDKVIDLHGHIIGMALSPDHRY 509
            ..| |||..|...:..:.            |.|...|...:|..||:.|...:....||....|
pombe   488 SNPLSLKGVITMSKHVKS------------WSYTIPKPFVNKRSKVLPLRPSVTHDNLSKSSDY 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fbw5	NP_608989.1	F-box-like	36..82	CDD:289689	17/42 (40%)
		WD40	126..157	CDD:197651	13/86 (15%)
		WD40 repeat	132..176	CDD:293791	12/56 (21%)
		WD40	<538..>644	CDD:225201
		WD40	<553..>637	CDD:295369
		WD40 repeat	566..600	CDD:293791
pof10	NP_596201.1	F-box-like	31..77	CDD:289689	17/42 (40%)
		WD40	124..507	CDD:225201	78/447 (17%)
		WD40 repeat	127..166	CDD:293791	2/38 (5%)
		WD40 repeat	171..210	CDD:293791	9/50 (18%)
		WD40	<208..>282	CDD:295369	14/93 (15%)
		WD40 repeat	221..262	CDD:293791	7/43 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5529
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030