DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9135 and HERC2

DIOPT Version :9

Sequence 1:	NP_001285655.1	Gene:	CG9135 / 33850	FlyBaseID:	FBgn0031769	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_004658.3	Gene:	HERC2 / 8924	HGNCID:	4868	Length:	4834	Species:	Homo sapiens

Alignment Length:	372	Identity:	102/372 - (27%)
Similarity:	161/372 - (43%)	Gaps:	61/372 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 RYVASGPSAAHTILINMDRKALGFGRNPSGQLGLSQDIKLAEKPTIIPALEQLNIVQAAVGRHHT 181
            |..|:|..:|.||    ..|...:|.|...|||..:..|: :.|:....|..||:||.|.|....
Human  2945 RKKAAGLESAATI----RTKVFVWGLNDKDQLGGLKGSKI-KVPSFSETLSALNVVQVAGGSKSL 3004

  Fly   182 LFLTDTGTVYACGENKSGQCGVGNTHANIYSPTPINYRGPPIIR---IGCGAEFSVILDIKGSLH 243
            ..:|..|.||||||..:|:.|:|.:...:..|..|......:::   :..|...:..|.:.|.:.
Human  3005 FAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVF 3069

  Fly   244 TFGLPEYGQLGH----NTDAKYFVNANKLSFHFETSPKKVVLYIEKSKEGHVTPVDGVQIVDFAC 304
            ::|..:.|:|||    |.|....:.|.|..                            :|.|.||
Human  3070 SWGEGDDGKLGHFSRMNCDKPRLIEALKTK----------------------------RIRDIAC 3106

  Fly   305 GNNHTVAIDSKKRVYSWGFGGFGRLGHAEPKDEMVPRLMKFFDTQGRGGRSVFCGS--TFSLIVN 367
            |::|:.|:.|...:|:||.|.:|||||.:...::.|:::|..  .|.....|.|||  ..:|.:.
Human  3107 GSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVL--LGHRVIQVACGSRDAQTLALT 3169

  Fly   368 ELGLLFLFGQNK--KTG----EANMYPKPVQDLSGWNITDIGC-ANTSIMISADDTLIAWGASPT 425
            :.||:|.:|...  |.|    |....|:.::.|:|..:..|.| |..|:.::....:..||....
Human  3170 DEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDY 3234

  Fly   426 FGELGIGEFQKSSTV----PKEVPKLDNIKIPQVTMGYSHTVLLVDT 468
            | .||.|     |.|    |:.|..|...||..|.:|..|.:.:.|:
Human  3235 F-RLGHG-----SDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDS 3275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9135	NP_001285655.1	RCC1	139..184	CDD:278826	14/44 (32%)
		RCC1_2	171..200	CDD:290274	12/28 (43%)
		RCC1	188..236	CDD:278826	13/50 (26%)
		RCC1	239..312	CDD:278826	16/76 (21%)
		RCC1	317..366	CDD:278826	17/50 (34%)
		RCC1	414..465	CDD:278826	16/54 (30%)
HERC2	NP_004658.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..88
		RCC1 1-1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	415..461
		RCC1 1-2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	462..512
		RCC1 1-3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	513..568
		RCC1	514..566	CDD:278826
		RCC1 1-4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	569..620
		RCC1	569..620	CDD:278826
		RCC1 1-5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	623..674
		RCC1	623..672	CDD:278826
		RCC1 1-6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	675..726
		RCC1	675..724	CDD:278826
		RCC1 1-7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	728..778
		Cyt-b5	1209..1282	CDD:278597
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1555..1575
		MIB_HERC2	1870..1929	CDD:284184
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1933..1958
		UBA_HERC2	2460..2507	CDD:270585
		Cul7	2554..2631	CDD:288381
		ZZ_HERC2	2706..2750	CDD:239084
		APC10-HERC2	2765..2910	CDD:176485
		RCC1 2-1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	2958..3009		15/51 (29%)
		RCC1	2960..3007	CDD:278826	15/47 (32%)
		RCC1 2-2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3010..3064		14/53 (26%)
		RCC1	3010..3062	CDD:278826	13/51 (25%)
		RCC1 2-3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3065..3116		17/78 (22%)
		RCC1	3065..3114	CDD:278826	16/76 (21%)
		RCC1	3117..3168	CDD:278826	17/52 (33%)
		RCC1 2-4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3118..3168		17/51 (33%)
		RCC1 2-5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3171..3222		14/50 (28%)
		RCC1	3171..3220	CDD:278826	14/48 (29%)
		RCC1	3223..3272	CDD:278826	16/54 (30%)
		RCC1 2-6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3224..3274		16/55 (29%)
		RCC1 2-7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3275..3326		0/1 (0%)
		RCC1	3275..3324	CDD:278826	0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3602..3629
		RCC1 3-1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	3951..4002
		RCC1 3-2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	4004..4056
		RCC1_2	4039..4069	CDD:290274
		RCC1	4057..4106	CDD:278826
		RCC1 3-3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	4058..4108
		RCC1 3-4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	4110..4162
		RCC1	4110..4160	CDD:278826
		RCC1	4163..4212	CDD:278826
		RCC1 3-5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	4164..4214
		RCC1	4215..4263	CDD:278826
		RCC1 3-6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	4216..4266
		RCC1	4267..4316	CDD:278826
		RCC1 3-7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00235, ECO:0000269\|Ref.21	4268..4318
		HECTc	4421..4792	CDD:238033
		HECTc	4464..4790	CDD:214523
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4804..4834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820