DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9135 and HERC3

DIOPT Version :9

Sequence 1:	NP_001285655.1	Gene:	CG9135 / 33850	FlyBaseID:	FBgn0031769	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_055421.1	Gene:	HERC3 / 8916	HGNCID:	4876	Length:	1050	Species:	Homo sapiens

Alignment Length:	390	Identity:	98/390 - (25%)
Similarity:	162/390 - (41%)	Gaps:	68/390 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 PNLYSFHRFTEEKYRYVASGPSAAHTILINMDRKALGFGRNPSGQLGLSQDIKLAEKPTIIPALE 167
            |.:..|  .::...:.||.|.:  |::.:..|.:....|.|..||||..::   ..||..|.||.
Human    25 PQVCGF--ISDRSVKEVACGGN--HSVFLLEDGEVYTCGLNTKGQLGHERE---GNKPEQIGALA 82

  Fly   168 QLNIVQAAVGRHHTLFLTDTGTVYACGENKSGQCGVGNTHANIYSPTPI-NYRGPPIIRIGCGAE 231
            ..:|:..|.|..|:|.|:|.|.:::.|....||.|:..|..::..|..| ......|:::.||..
Human    83 DQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNW 147

  Fly   232 FSVILDIKGSLHTFGLPEYGQLGHNTDAKYFVNANKLSFHFETSPKKVVLYIEKSKEGHVTPVDG 296
            ..:.|...|...|:|...:||||...:           |..:.||::            |..::|
Human   148 HCLALAADGQFFTWGKNSHGQLGLGKE-----------FPSQASPQR------------VRSLEG 189

  Fly   297 VQIVDFACGNNHTVAIDSKKRVYSWGFGGFGRLGHAEPKDEMVPRLMKFFDTQGRGGRSVF--CG 359
            :.:...|.|..|:.|:.....|:.||....|:||.::.||...|..:|...||    :.|:  ||
Human   190 IPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQ----KVVYISCG 250

  Fly   360 STFSLIVNELGLLFLF--------GQNKKTGEANMYPKPVQDLSGWNITDIGCA--NTSIMISAD 414
            ...:.::.:.|.:|.|        |.:....|.|  |:.|.:|.|..:|.|.|.  :|...:.:.
Human   251 EEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVN--PRRVLELMGSEVTQIACGRQHTLAFVPSS 313

  Fly   415 DTLIAWGASPTFGELGIGEFQKSSTVPKEVPKLDNIKIPQVTMGY--SHTVLLVDTTHEATKQKY 477
            ..:.|:|.... |:||.|.             ..|:|.|....||  :|:..|   :..|.:.||
Human   314 GLIYAFGCGAR-GQLGTGH-------------TCNVKCPSPVKGYWAAHSGQL---SARADRFKY 361

Fly 478 477
Human 362 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9135	NP_001285655.1	RCC1	139..184	CDD:278826	16/44 (36%)
		RCC1_2	171..200	CDD:290274	9/28 (32%)
		RCC1	188..236	CDD:278826	11/48 (23%)
		RCC1	239..312	CDD:278826	15/72 (21%)
		RCC1	317..366	CDD:278826	15/50 (30%)
		RCC1	414..465	CDD:278826	12/52 (23%)
HERC3	NP_055421.1	RCC1 1	1..51		6/29 (21%)
		ATS1	2..331	CDD:227511	87/342 (25%)
		RCC1 2	52..101		18/51 (35%)
		RCC1 3	102..154		12/51 (24%)
		RCC1 4	156..207		16/73 (22%)
		RCC1 5	208..259		15/54 (28%)
		RCC1 6	261..311		14/51 (27%)
		RCC1	313..377	CDD:366085	16/66 (24%)
		RCC1 7	313..366		16/66 (24%)
		HECTc	702..1048	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920