DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9135 and EEA1

DIOPT Version :9

Sequence 1:	NP_001285655.1	Gene:	CG9135 / 33850	FlyBaseID:	FBgn0031769	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	XP_011537116.1	Gene:	EEA1 / 8411	HGNCID:	3185	Length:	1453	Species:	Homo sapiens

Alignment Length:	310	Identity:	58/310 - (18%)
Similarity:	110/310 - (35%)	Gaps:	62/310 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KKKESDYEDEFSDESDDDGVQQQAAAANQMEVLIPHDDLDPPSKLPEDLLATLEKTPGQMLIAGM 84
            ::.::|.|.......|.|...|...|..|..    .:::....|..|||.|.::...|:..:...
Human   547 REAQNDLEQVLRQIGDKDQKIQNLEALLQKS----KENISLLEKEREDLYAKIQAGEGETAVLNQ 607

  Fly    85 V----------TWDLTGKRDRKNVT--KVRPNLYSFHRFTEEKYRYVASGPSAAHTILINMDRKA 137
            :          ...||.|...::.:  :.:.||   |...:|:..::    .||...:::::...
Human   608 LQEKNHTLQEQVTQLTEKLKNQSESHKQAQENL---HDQVQEQKAHL----RAAQDRVLSLETSV 665

  Fly   138 --LGFGRNPSGQLGLSQDIKLAEKPTIIPALEQLNIVQAAVGRHH---------------TLFLT 185
              |....|.|.:.....||::..|..::.:.|.....|.|..::|               ....|
Human   666 NELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITT 730

  Fly   186 DTGTVYACGENKSGQCGVGNTHANIYSPTPINYRGP------PIIRIGCGAEFSVILDIKGSLHT 244
            ....|.|..::|...|....:|...|....::....      .|.::...:     |::|.|...
Human   731 QLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADS-----LEVKASKEQ 790

  Fly   245 F--GLPEYGQLGHNTDAKYFVNANKLSFHFETSPKKVV----LYIEKSKE 288
            .  .|.:..||  |||.:  :.|.:||...|.. |::|    |.::|..|
Human   791 ALQDLQQQRQL--NTDLE--LRATELSKQLEME-KEIVSSTRLDLQKKSE 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9135	NP_001285655.1	RCC1	139..184	CDD:278826	9/59 (15%)
		RCC1_2	171..200	CDD:290274	7/43 (16%)
		RCC1	188..236	CDD:278826	7/53 (13%)
		RCC1	239..312	CDD:278826	17/56 (30%)
		RCC1	317..366	CDD:278826
		RCC1	414..465	CDD:278826
EEA1	XP_011537116.1	Myosin_tail_1	308..1382	CDD:279860	58/310 (19%)
		DUF342	<425..519	CDD:302792
		FYVE_EEA1	1389..1451	CDD:277269
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900