DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9135 and RCBTB1

DIOPT Version :9

Sequence 1:	NP_001285655.1	Gene:	CG9135 / 33850	FlyBaseID:	FBgn0031769	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_001339429.1	Gene:	RCBTB1 / 55213	HGNCID:	18243	Length:	531	Species:	Homo sapiens

Alignment Length:	360	Identity:	82/360 - (22%)
Similarity:	134/360 - (37%)	Gaps:	101/360 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 GPSAAHTILINMDRKALGFGRNPSGQLGLSQDIKLAEKPTIIP-ALEQL---NIVQAAVGR-HHT 181
            |.||:..:.:..:.:...||.|.|..||...:     :.|::| .||.|   .|...:.|. .|.
Human    28 GTSASEALYVTDNDEVFVFGLNYSNCLGTGDN-----QSTLVPKKLEGLCGKKIKSLSYGSGPHV 87

  Fly   182 LFLTDTGTVYACGENKSGQCGVGNTHANIYSPTPI--NYRGPPIIRIGCGAEFSVILDIKGSLHT 244
            |..|:.|.|||.|.|...|.|.|.|:..| :|..:  |.....::.:.||:..|:.|...|.:..
Human    88 LLSTEDGVVYAWGHNGYSQLGNGTTNQGI-APVQVCTNLLIKQVVEVACGSHHSMALAADGEVFA 151

  Fly   245 FGLPEYGQLGHNTDAKYFVNANKLSFHFETSPKKVV--LYIEKSKEGHVTPVDGVQIVDFACGNN 307
            :|....||:|..:.|.            :.:|:||.  |:|::             :|..|||..
Human   152 WGYNNCGQVGSGSTAN------------QPTPRKVTNCLHIKR-------------VVGIACGQT 191

  Fly   308 HTVAIDSKKRVYSWGFGGFGRLGHAEPKDEMVPRLMKFFDTQGRGGRSVFCGSTFSLIVNELGLL 372
            .::|:.....||.||:.|.|:||.....:::.|  ::...........:.||...:|.:.:.|||
Human   192 SSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTP--VRVAALHSVCVNQIVCGYAHTLALTDEGLL 254

  Fly   373 FLFGQNKKTGEANMYPKPVQDLSGWNITDIGCANTSIMISADDTLIAWGASPTFGELGIGEFQKS 437
            :                                             ||||: |:|:||.|
Human   255 Y---------------------------------------------AWGAN-TYGQLGTG----- 268

  Fly   438 STVPKEVPKLDNIKIPQVTMGYSHTVLLVDTTHEA 472
                    ..:|:..|...|.....|:.:...|.|
Human   269 --------NKNNLLSPAHIMVEKERVVEIAACHSA 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9135	NP_001285655.1	RCC1	139..184	CDD:278826	15/49 (31%)
		RCC1_2	171..200	CDD:290274	11/29 (38%)
		RCC1	188..236	CDD:278826	16/49 (33%)
		RCC1	239..312	CDD:278826	15/74 (20%)
		RCC1	317..366	CDD:278826	12/48 (25%)
		RCC1	414..465	CDD:278826	13/50 (26%)
RCBTB1	NP_001339429.1	RCC1 1	40..91		15/55 (27%)
		ATS1	43..>316	CDD:227511	79/345 (23%)
		RCC1 2	93..145		17/52 (33%)
		RCC1 3	147..198		16/75 (21%)
		RCC1 4	199..250		12/52 (23%)
		RCC1 5	252..302		18/103 (17%)
		RCC1 6	304..356
		BTB_POZ_RCBTB1_CLLD7	350..466	CDD:349662
		BACK_RCBTB1	466..531	CDD:350603
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820