DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9135 and HERC6

DIOPT Version :9

Sequence 1:	NP_001285655.1	Gene:	CG9135 / 33850	FlyBaseID:	FBgn0031769	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	XP_005263140.1	Gene:	HERC6 / 55008	HGNCID:	26072	Length:	1034	Species:	Homo sapiens

Alignment Length:	337	Identity:	88/337 - (26%)
Similarity:	135/337 - (40%)	Gaps:	81/337 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 IVQAAVGRHHTLFLTDTGTVYACGENKSGQCG------------VGNTHANIYSPTPINYRGPPI 223
            ::|||.|..|:|.|.....|.:||:|..||.|            ||.... ::...||......|
Human    25 LLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPVVVGGCFV-LFPKEPIQALETLI 88

  Fly   224 I-RIGCGAEFSVILDIKGSLHTFGLPEYGQLGHNTDAKYFVNANKLSFHFETSPKKVVLYIEKSK 287
            : .:.||.|.|:.:..||.:..:|....||||       .....::||    :|||::
Human    89 VDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLG-------IGEFKEISF----TPKKIM------- 135

  Fly   288 EGHVTPVDGVQIVDFACGNNHTVAIDSKKRVYSWGFGGFGRLGHAEPKDEMVPRLMKFFDTQ--- 349
                 .::.::|:..:||:.|::|:....:|:|||....|:||           |.|.|.:|
Human   136 -----TLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLG-----------LGKEFPSQASP 184

  Fly   350 --------------GRGGRSVF----CGSTFSLIVNELGLLFLFGQNKKTGEANMYPKPVQDLSG 396
                          ..||...|    ||::|....|..|.|.|.|:|... ::|. |..|..|..
Human   185 QRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPV-QSNK-PLSVGALKN 247

  Fly   397 WNITDIGCANTSIMISADDTLIAWGASPTFGELGIGEFQKSSTVPKEVPKL----DNIKIPQVTM 457
            ..:..|.|.:....:...|     |...|||:...|:...|.|..|..|:|    |.: :.|:..
Human   248 LGVVYISCGDAHTAVLTQD-----GKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL-VSQIDC 306

  Fly   458 GYSHTVLLVDTT 469
            |..||:..|.||
Human   307 GSYHTLAYVHTT 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9135	NP_001285655.1	RCC1	139..184	CDD:278826	6/12 (50%)
		RCC1_2	171..200	CDD:290274	11/28 (39%)
		RCC1	188..236	CDD:278826	16/60 (27%)
		RCC1	239..312	CDD:278826	16/72 (22%)
		RCC1	317..366	CDD:278826	17/69 (25%)
		RCC1	414..465	CDD:278826	16/54 (30%)
HERC6	XP_005263140.1	RCC1_2	27..54	CDD:290274	11/26 (42%)
		RCC1_2	89..118	CDD:290274	7/28 (25%)
		RCC1	105..155	CDD:278826	16/72 (22%)
		RCC1	158..208	CDD:278826	14/60 (23%)
		RCC1	215..263	CDD:278826	13/49 (27%)
		RCC1_2	250..279	CDD:290274	7/33 (21%)
		RCC1	266..313	CDD:278826	16/52 (31%)
		HECTc	684..1026	CDD:238033
		HECTc	711..1026	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920