DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9135 and nek8

DIOPT Version :9

Sequence 1:	NP_001285655.1	Gene:	CG9135 / 33850	FlyBaseID:	FBgn0031769	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	XP_012812229.1	Gene:	nek8 / 448753	XenbaseID:	XB-GENE-990378	Length:	698	Species:	Xenopus tropicalis

Alignment Length:	463	Identity:	118/463 - (25%)
Similarity:	168/463 - (36%)	Gaps:	142/463 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 LIAGMVTWDLTGKRDRKNVTKVRP-------NLYSFHRFTEEKYRYV----ASGPSAAHTILINM 133
            ||..|:..| ..||.:.|.....|       ||||  .....|.|.|    ||.|:.:..
Frog   234 LILSMLNLD-PSKRPQLNEIMAHPICIPALLNLYS--DIGSVKMRRVEKPLASVPAVSRV----- 290

  Fly   134 DRKA--LGFGRNPSGQLGLSQDIKLAEKPTIIPALEQL------------------NIVQAAVGR 178
             |.|  :...|:..|::|.|     ..||.|.|.|..:                  .:||.:.||
Frog   291 -RPASRIPSARSRGGRVGHS-----PAKPGIPPPLSSVYTWGSGISTPLRLPMLNTEVVQVSAGR 349

  Fly   179 HHTLFLTDTGTVYACGENKSGQ------CGVGNTHANIYSPTPINYRGPPII------------- 224
                       ....|..|||:      ..||....::  |..|.:..|..|
Frog   350 -----------TQKAGVTKSGRLIMWEATPVGTGAPSL--PGSIEHAQPQFISRFLEGQSGVTIK 401

  Fly   225 RIGCGAEFSVILDIKGSLHTFGLPEYGQLGHNTDAKYFVNANKLSFHFETSPKKVVLYIEKSKEG 289
            .:.||..|:..|..:|.:.|||....|.|||         ||   |:..|.||
Frog   402 HVSCGDLFTACLTDRGIIMTFGSGSNGCLGH---------AN---FNDVTQPK------------ 442

  Fly   290 HVTPVDGVQIVDFACGNNHTVAIDSKKRVYSWGFGGFGRLG------HAEPKDEMVPRLMKFFDT 348
            .|..:.|.:||..:||.:|.:|:.::|.|:|||.|..||||      :..|:..::|   ..::.
Frog   443 IVEDLLGYEIVHVSCGASHAIAVSNEKEVFSWGRGDNGRLGLGSQESYNSPQQVIIP---PEYEA 504

  Fly   349 QGRGGRSVFCGSTFSLIVNELGLLFLFGQNK--KTG-----------------EANMYPKPVQDL 394
            |     .|.||...|:|:.....|...|.|:  |.|                 ||..: .|:|.
Frog   505 Q-----RVVCGIDSSMILTVANQLLACGSNRFNKLGFDRILSASEPSSEDQVEEAYTF-TPIQS- 562

  Fly   395 SGWNITDIGCANTSIMISADDTLIAWGASPTFGELGIGEF----QKSSTVPKEVPKLDNIKIPQV 455
            :..|...|.||:.....||  .:.|.|...|||....|:.    .::|.||..|..|..:|:..|
Frog   563 APLNQEAILCADVGTSHSA--VVTALGQCYTFGSNQHGQLGTSAHRNSRVPCLVSALQGVKVTMV 625

  Fly   456 TMGYSHTV 463
            ..|.::||
Frog   626 ACGDAYTV 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9135	NP_001285655.1	RCC1	139..184	CDD:278826	13/62 (21%)
		RCC1_2	171..200	CDD:290274	7/28 (25%)
		RCC1	188..236	CDD:278826	13/66 (20%)
		RCC1	239..312	CDD:278826	21/72 (29%)
		RCC1	317..366	CDD:278826	16/54 (30%)
		RCC1	414..465	CDD:278826	16/54 (30%)
nek8	XP_012812229.1	STKc_Nek8	3..258	CDD:270859	8/24 (33%)
		S_TKc	4..256	CDD:214567	7/22 (32%)
		ATS1	320..657	CDD:227511	89/363 (25%)
		RCC1	421..465	CDD:278826	20/67 (30%)
		RCC1	470..517	CDD:278826	16/54 (30%)
		RCC1	587..635	CDD:278826	15/47 (32%)
		RCC1	638..687	CDD:278826
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010