DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9135 and Nek9

DIOPT Version :9

Sequence 1:	NP_001285655.1	Gene:	CG9135 / 33850	FlyBaseID:	FBgn0031769	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_001100217.2	Gene:	Nek9 / 299204	RGDID:	1307187	Length:	976	Species:	Rattus norvegicus

Alignment Length:	464	Identity:	100/464 - (21%)
Similarity:	179/464 - (38%)	Gaps:	114/464 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 LDPPSKLPEDLLATLEKTPGQMLIAGMVTWDLTGKRDRKNVTKVRPNLYSF--HRFTEEKYRYVA 120
            |:.|:|.|..  :|:.:.|..:                  ||.....:|.:  .:.|.:|...:.
  Rat   321 LNAPTKRPRS--STVTEAPIAV------------------VTSRTSEVYVWGGGKSTPQKLDVIK 365

  Fly   121 SGPSA-------AHTILINMDRKALGF-----GRNPSGQLGLSQDIKLAEKPTIIPALEQLNIVQ 173
            ||.||       .|..::.::::...:     |....|||| ..|.....:|..:..|:...|.|
  Rat   366 SGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLG-HGDKASYRQPKHVEKLQGKAIHQ 429

  Fly   174 AAVGRHHTLFLTDTGTVYACGENKSGQCGVGNTHA-NIYSPTPIN-YRGPPIIRIGCGAEFSVIL 236
            .:.|...|:.:||.|.:||.|.:..|..||..... .:..|..:| :...|:.::.||....|:|
  Rat   430 VSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVSGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVL 494

  Fly   237 DIKGSLHTFGLPEYGQLGHNTDAKYFVNANKLSFHFETSPKKVVLYIEKSKEGHVTPVDGVQIVD 301
            .....::::|..|||:||.:::..|:            :|::|  .:.|:          :.||.
  Rat   495 TRNKEVYSWGCGEYGRLGLDSEEDYY------------TPQRV--DVPKA----------LIIVA 535

  Fly   302 FACGNNHTVAIDSKKRVYSWGFGGFGRLG--------------HAEP--KDEMVPRLMKFFDTQG 350
            ..||.:.|..:....:|.:.|...|.:||              |..|  ....:.:.:.|:..
  Rat   536 VQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKI-- 598

  Fly   351 RGGRSVFCGSTFSLIVNELGLLFLFGQNK--KTGEANMYPKPV------QDLSGWNITDIGCANT 407
               |::..|.|.:..::|.|.|..||.||  :.|..| |.|.:      ..|.|..:..:.|.:.
  Rat   599 ---RTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGN-YKKRLGINLLGGPLGGKQVIRVSCGDE 659

  Fly   408 SIMISADDT-LIAWGASPTFGELGIGEFQKSSTVPKEVPKLDNI-------------KIPQVTMG 458
            ..:.:.||. :.|||..      |.|   :.:..|.|.|...:|             .:|.::..
  Rat   660 FTIAATDDNHIFAWGNG------GNG---RLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCR 715

  Fly   459 YSHTVLLVD 467
            ..||:|:|:
  Rat   716 GWHTILIVE 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9135	NP_001285655.1	RCC1	139..184	CDD:278826	12/49 (24%)
		RCC1_2	171..200	CDD:290274	10/28 (36%)
		RCC1	188..236	CDD:278826	13/49 (27%)
		RCC1	239..312	CDD:278826	15/72 (21%)
		RCC1	317..366	CDD:278826	11/64 (17%)
		RCC1	414..465	CDD:278826	14/64 (22%)
Nek9	NP_001100217.2	STKc_Nek9	50..297	CDD:270860
Nek9	NP_001100217.2	ATS1	344..687	CDD:227511	84/382 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010