DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9135 and Rcc2

DIOPT Version :9

Sequence 1:	NP_001285655.1	Gene:	CG9135 / 33850	FlyBaseID:	FBgn0031769	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	XP_038967259.1	Gene:	Rcc2 / 298594	RGDID:	1309986	Length:	520	Species:	Rattus norvegicus

Alignment Length:	518	Identity:	229/518 - (44%)
Similarity:	308/518 - (59%)	Gaps:	42/518 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RKAG--------GNG---AGPNKR-RPKKKESDYEDEFSDES------DDDGVQQQAAAANQMEV 51
            ||.|        |||   |||.:| .|..::.:..:..|..|      |:||.:...|.......
  Rat     3 RKKGAAWEEPSSGNGTARAGPRRRGGPAGRKRERPERCSSSSGGGSSGDEDGPELDGAPGGGKRT 67

  Fly    52 LIPHDD---------LDPPSKLPEDLLATLEKTPGQMLIAGMVTWDLTGKRDRKNVTK------- 100
            ..|...         :..|....|.:.....|..||:||.|...|||.|   ||.|.|
  Rat    68 ARPATAGKASGAAAIITEPEHTKERVKLEGSKCKGQLLIFGATNWDLIG---RKEVPKQQAAYRN 129

  Fly   101 VRPNLYSFHRF---TEEKYRYVASGPSAAHTILINMDRKALGFGRNPSGQLGLSQDIKLAEKPTI 162
            :..||:..||:   :..:.|.|.||..|||::||..:.|...:|||..|||| ..|.|..|.|.:
  Rat   130 LGQNLWGPHRYGCLSGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLG-HGDTKRVEAPRL 193

  Fly   163 IPALEQLNIVQAAVGRHHTLFLTDTGTVYACGENKSGQCGVGNTHANIYSPTPINYRGPPIIRIG 227
            |.||....||.||.||:|||.|||||:|:|.||||.||.|:||....:.||..|.|.|.||.::.
  Rat   194 IEALSHEAIVLAACGRNHTLALTDTGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMA 258

  Fly   228 CGAEFSVILDIKGSLHTFGLPEYGQLGHNTDAKYFVNANKLSFHFETSPKKVVLYIEKSKEGHVT 292
            ||||||:::|.||:|::||.|||||||||:|.|:...|.::.:..|..|::|.::|||:|:|.:.
  Rat   259 CGAEFSMLMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQIL 323

  Fly   293 PVDGVQIVDFACGNNHTVAIDSKKRVYSWGFGGFGRLGHAEPKDEMVPRLMKFFDTQGRGGRSVF 357
            ||..|.:.|.|||.|||:.:||:|||:||||||:|||||||.||||||||:|.||..|||...::
  Rat   324 PVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGATQIY 388

  Fly   358 CGSTFSLIVNELGLLFLFGQNKKTGEANMYPKPVQDLSGWNITDIGCANTSIMISADDTLIAWGA 422
            .|.|.|..|:|:|.||.:|....:.|:.||||.||||.||.|..:.|..:||:::||::.|:||.
  Rat   389 AGYTCSFAVSEVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGP 453

  Fly   423 SPTFGELGIGEFQ-KSSTVPKEVPKLDNIKIPQVTMGYSHTVLLVDTTHEATKQKYEKMPEYT 484
            ||||||||.|:.: ||||..:||..||.|...||.|||||::::.....||.|::.:::||||
  Rat   454 SPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARDESEAEKERLQRLPEYT 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9135	NP_001285655.1	RCC1	139..184	CDD:278826	23/44 (52%)
		RCC1_2	171..200	CDD:290274	20/28 (71%)
		RCC1	188..236	CDD:278826	25/47 (53%)
		RCC1	239..312	CDD:278826	35/72 (49%)
		RCC1	317..366	CDD:278826	32/48 (67%)
		RCC1	414..465	CDD:278826	29/51 (57%)
Rcc2	XP_038967259.1	ATS1	129..479	CDD:227511	178/350 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350438
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10282
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1807
OMA	1	1.010	-	-		QHG54771
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0006921
OrthoInspector	1	1.000	-	-		oto98293
orthoMCL	1	0.900	-	-		OOG6_105844
Panther	1	1.100	-	-	LDO	PTHR46207
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4391
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910